System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or I

A controller, patient technology, applied in the direction of devices, drugs or prescriptions, hypodermic injection devices introduced into the body, etc., can solve problems such as unreliability and time-consuming for patients

Inactive Publication Date: 2006-11-08
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite its technical simplicity, this method is time-consuming and unreliable for patients

Method used

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  • System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or I
  • System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or I
  • System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or I

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Embodiment Construction

[0037] exist Figure 1-5 A system according to an embodiment of the invention is shown in . Such as figure 1 As shown in FIG. 2 , system 100 may generally be configured as a drug delivery system including a controller 102 , a drug delivery system, and an analyte sensor system 106 . As noted, controller 102 provides control signals that control drug delivery system 104 to deliver the appropriate amount of drug to patient 108 . The analyte sensor system senses the level of an analyte of interest in patient 108 and provides a sensor signal to controller 102 . A reference or set point signal indicative of a target level of the analyte is also input to the controller. The controller 102 may then adjust the control signal accordingly based on the sensor signal and the reference signal to adjust the amount of drug delivered to the patient 108 by the drug delivery system 104 .

[0038] Such as figure 2 As shown in , system 100 may be configured within a portable, wearable closed...

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Abstract

A closed loop therapy system (200) for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system (206) that measures a glucose level in the body, a controller (202) that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.

Description

technical field [0001] The present invention relates to a system and method for maintaining continuous, long-term control of the concentration of a substance in a patient and for determining a fixed or time-varying profile of a target concentration of said substance. More specifically, the present invention relates to a continuous, long-term approach to maintaining blood glucose concentrations in diabetic patients near a target profile using a control algorithm, such as a feedback or model-based controller coupled to intradermal (ID) delivery of insulin. A system and method of control wherein the insulin is preferably a short-acting insulin analog delivered by a single needle or a multiple needle array. This application claims the benefit of Provisional Patent Application No. 60 / 417,559, filed October 11, 2002, and Provisional Patent Application No. 60 / 432,233, filed December 11, 2002, under 35 U.S.C. § 119(e), both of which are The entire contents of the patent application a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61K9/22A61K38/28A61M5/142A61M5/172
CPCA61K38/28A61M5/172A61M31/002A61M2005/14208A61M2230/201G16H40/63A61P3/10G16H20/17A61M5/168A61M5/31A61M5/00A61M31/00
Inventor 史蒂文·基思罗纳德·派蒂斯诺埃尔·哈维约翰·D·德努齐奥罗伯特·S·帕克
Owner BECTON DICKINSON & CO
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