The invention provides a collagen biphasic
system cross-linking material, a preparation method thereof and an implantation
stent, relates to a high-molecular compound composition, relates to a high-molecular compound composition, and also relates to the technical field of medical materials. According to the preparation method of the collagen two-phase
system cross-linking material, in the
nucleation period, low-concentration
hydrogen peroxide is introduced, so that collagen self-
assembly and
hydrogen peroxide cross-linking are carried out synergistically; in the growing period, a
hydrogen peroxide solution with relatively
high concentration is added, so that a covalent cross-linked network and
fiber extension are synchronously formed, and a self-
assembly regulation process in the growing period can greatly prolong the collagen self-
assembly time, so that cross-linking is more thorough, and structure-function
synergy on a molecular scale is realized; finally,
hydrogen peroxide is decomposed into water and
oxygen, no crosslinking agent is left, the prepared collagen biphasic
system crosslinking material has good mechanical performance and enzymolysis resistance, and the in-vivo complete degradation time can be controlled within 12-24 months.