Nano-fiber tubular scaffold with multi-stage porous structure

Abstract

The invention relates to a tissue engineering tubular scaffold with a multi-stage porous structure. The scaffold comprises at least one channel which is axially arranged, the area of the cross section of the channel is 300 mu m2-300 mm2, the non-channel part of the scaffold has micropores which are interconnected, the volume range of the micropores is 1 mu m3-5000 mu m3, the pore diameter distribution curve of the micropores is serrated, and the microporous wall of the scaffold is a nano-fiber three-dimensional network. Simultaneously, drugs with the function of changing physiological actionsof cells and tissues are contained in the scaffold, the functional drugs are released according to a certain rule to the environment located by the scaffold during the application process, and the types, the loading quantities and the release rate of the drugs can be set according to the actual needs. The tissue engineering scaffold with a fine topological structure and the physiological functionhas broad prospects.

Description

Technical field [0001] The invention relates to a tissue engineering tubular stent, in particular to a multi-channel nanofiber drug sustained-release stent with a hierarchical pore structure. Background technique [0002] In recent years, tissue engineering has achieved rapid development as a new technology to repair and rebuild tissues. As a support for the growth and development of cells and tissues, and a carrier for cytokines and functional drugs, the tissue engineering tubular scaffold has attracted the attention of researchers during the development of tissue engineering technology. As the basis of tissue engineering technology, the application environment of tissue engineering tubular scaffold is quite complicated. Therefore, when designing and preparing a tissue engineering tubular scaffold, it is necessary to consider multiple angles and take into account various factors in order to be more adaptable to complex environments, achieve good repair effects, and effectively ...

AI Technical Summary

Problems solved by technology

[0003] At present, in the scientific research and clinical application of tissue engineering, the scaffolds with nano-scale fiber three-dimensional network form are single and imprecise in structural parameters and forms, lack of channels of various shapes and distributions, and have no multiple sizes and grades. Micropores of different shapes, so only simple experimental results and limited clinical effects can be obtained

[0004] On the other hand, in the research and application of existing drug sustained-release systems, most of them are microspheres with one-dimensional structure and membranes with two-dimensional structure. release stent model

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