30 results about "Neural Growth" patented technology

The invention relates to the novel identification of inhibitors of phosphodiesterase type 4 (“PDE4”) as agents which can reverse inhibition of neural regeneration in the mammalian central and peripheral nervous system. The invention provides compositions and methods using agents that can reverse the inhibitory effects on neural regeneration by regulating PDE4 expression. A composition comprising at least one PDE4 inhibitor in an amount effective to inhibit PDE4 activity in a neuron when administered to an animal is provided. Methods for regulating (e.g., promoting) neural growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with disorders or diseases, comprising the step of administering to an animal a composition comprising a therapeutically effective amount of an agent which inhibits phosphodiesterase IV activity in a neuron are provided.

The invention relates to neuroprotection and to medicaments for use therein. Neuroprotection is induced by activation of neural growth hormone receptors, primarily using medicaments comprising growth hormone, growth hormone analogs or ligands which are functionally equivalent. Such medicaments may also include one or more secondary neuroprotective agents.

The present invention provides a peripheral nerve growth scaffold including poly ε-caprolactone (PCL) and microgrooves on an inner surface of the scaffold, the scaffold being adapted for use in treatment of damaged peripheral nerves. The microgrooves are suitably arranged as a pattern or array and preferably comprise sloping side walls, which arrangement has been found to provide a favourably environment for nerve and Schwann cell growth and proliferation. Experimental results demonstrate directed and aligned growth, which suitably reduces the rate of formation of neuromas. Embodiments comprising a PCL-PLA blend of the sloping side wall and a groove width greater than the spacing between adjacent grooves has been found to be particularly effective for directed cell growth and proliferation.

The invention relates to a ceramide compound; in the structural general formula, m=2-12; n=0-20. The ceramide compound has significant pseudo neural growth factor activity, and is the small molecule compound capable of passing through blood-brain barrier. The structural general formula is shown as Figure.

The invention discloses a bone repair scaffold material capable of mediating nervalization and a preparation method and application thereof. The preparation method comprises the steps that heterologous expression bone matrix fusion protein is adsorbed into calcium and magnesium doped mesoporous bioactive glass prepared through a sol-gel and template self-assembly method to serve as an inner core; nerve growth factors capable of promoting nerve growth are loaded into silk protein to serve as a shell, and then the bone repair scaffold material which is of a core-shell structure and can be used for mediating nervalization is prepared through a coaxial electrostatic spinning technology. The bone repair scaffold material capable of mediating the nervalization has good cell compatibility, osteogenic activity, neurogenic activity and calcium deposition promotion effects, can promote proliferation, differentiation and mineralization processes of bone marrow mesenchymal stem cells in the osteogenic direction, can also promote the survival process of neurons, as a bone repair material, the material has a wide prospect in clinical application of repairing bone defects and restoring consciousness of injured parts.

Although it is known that certain benzylpiperazine-aminopyridines or open chain forms thereof are effective in stimulating neural growth in in vitro tests, it has now been surprisingly found that administering these compounds in a dosage range of 10 mg/day-130 mg/day over 25-35 days is effective in treating Major Depressive Disorder (MDD) such that statistically significant results can be obtained with samples of only six subjects.

The invention features a method for promoting neural growth in vivo in the mammalian central nervous system by administering a neural cell adhesion molecule which can overcome inhibitory molecular cues found on glial cells and myelin to promote neural growth. Also featured active fragments, cognates, congeners, mimics, analogs, secreting cells and soluble molecules thereof, as well as antibodies thereto, and DNA molecules, vectors and transformed cells capable of expressing them. The neuroprotective of the agents as well as their ability to promote and effect myelination and remyelination are also disclosed, as are the concomitant benefits that these capabilities confer, in the former instance, with regard to reduction of apoptosis and necrosis, and in the latter instance, the treatment of Parkinsonism, Alzheimer's disease and multiple sclerosis. The invention also includes transgenic mouse lines expressing a neural adhesion molecule in differentiated astrocytes, and cells and tissues derived therefrom. The expression of the neural adhesion molecule enhances neurite outgrowth on central nervous system tissue derived from these transgenic mice. The invention also features methods for enhancing neuronal outgrowth of CNS neurons, for enhancing memory and for increasing synaptic efficacy. Also featured are methods of testing drugs which modulate the effects of the neural adhesion molecule, and assay systems suitable for such methods.

The invention discloses a pump for slowly promoting nerve growth, and particularly relates to the field of biomedical application. The pump comprises a tube body, the tube body comprises a semi-permeable membrane layer, a slow release layer and an impermeable membrane layer, the slow release layer is arranged at the periphery of the impermeable membrane layer, and the semi-permeable membrane layeris arranged at the periphery of the slow release layer; the semi-permeable membrane layer comprises a semi-permeable membrane and a protective layer, the protective layer is located on the peripheryof the semi-permeable membrane, the protective layer comprises an annular support and a cylindrical support, and the annular support is fixedly arranged on the periphery of the cylindrical support; and a plurality of groups of isolating membranes penetrate through the interior of the slow release layer, are arranged around the periphery of the impermeable membrane layer, and comprise elastic fibers and reinforcing fibers. By arranging the semi-permeable membrane layer, the slow release layer and the impermeable membrane layer, the stretching effect on damaged neurons is more uniform, the growth of damaged neurons can be prolonged through repeated micro-damage repairing, irritation to the damaged neurons is low, and growth and recovery of the neurons can be better promoted.

The present disclosure generally relates to a cell culturing system, and specifically to a three-dimensional cell culturing system for neuronal cells that promotes both structural and functional characteristics that mimic those of in vivo peripheral fibers, including cell myelination. Using a dual hydrogel construct and spheroids comprising neuronal cells, the present disclosure provides methods,devices, and systems for in vitro spatially-controlled, three-dimensional models that permit intra- and extra-cellular electrophysiological measurements and recordings. The three-dimensional hydrogelconstructs allow for flexibility in incorporated cell types, geometric fabrication, and electrical manipulation, providing viable systems for culture, perturbation, and testing of biomimetic neural growth with physiologically-relevant results.