27 results about "Muscle structures" patented technology

The invention discloses hydrogel for repairing volumetric muscle defects and a preparation method of the hydrogel, and the hydrogel is prepared from oxidized dextran, an alcohol-polyamino acid-bilirubin polymer and 3, 3 '-dithio-bis (propionyl hydrazide) according to the weight ratio of (50-75): (4-20): 1. The alcohol-polyamino acid-bilirubin polymer is prepared from an alcohol-polyamino acid polymer and bilirubin in a weight ratio of (6-25): 1. The hydrogel prepared by the invention not only has good characteristics of pH / ROS responsiveness, relatively strong tissue adhesion, antibacterial property, oxidation resistance and relatively low cytotoxicity, but also can remarkably promote cell migration, proliferation, new angiogenesis and myoblast differentiation, promote recovery of muscle structures and motor functions after volumetric muscle defects, and improve the recovery rate of muscle tissues and motor functions after the volumetric muscle defects. The material is expected to become a novel bioactive material capable of promoting volume muscle defect repair, and has a good application prospect in clinical treatment of large-volume tissue defect regeneration.

The utility model provides a kind of electromagnetic valve filter, including filter body, the filter body is the rotary body with central axis as rotary shaft, it has in integral coaxial connection connecting portion and filter part, the sidewall of the filter part is provided with filter mesh, the inner wall of the connecting portion is provided with the muscle structure that surrounds a circle, the surface of the muscle structure is cambered surface.The utility model can significantly reduce the deformation range of plastic parts, and stress is concentrated in muscle position, reduce the risk of functional area damage, reduce the demoulding resistance, avoid convex rib pull wool or breakage.

The invention provides a muscle mass evaluation method and system, and relates to the technical field of medical imaging, and the method comprises the steps: carrying out the ultrasonic scanning of human limbs, collecting an ultrasonic total scattering signal, and obtaining an ultrasonic image; acquiring a muscle structure image according to the ultrasonic image; performing segmentation processing on the muscle structure image to obtain contour information of a target muscle; and calculating the cross-sectional area and volume of the target muscle based on the contour information. According to the invention, the annular probe performs three-dimensional spiral scanning in the scanning process, and simultaneously obtains spatial information in the horizontal and vertical directions; echo signals are processed by adopting a delay superposition beam forming algorithm, and image segmentation is carried out in combination with a deep learning technology. According to the invention, radiation-free, high-precision, low-cost and portable muscle mass measurement is realized, and the method is especially suitable for evaluation, screening and monitoring of sarcopenia.

Determining properties of muscle structures using artificial neural networks. Techniques for determining a quantification of at least one property of a muscle structure including at least one muscle and at least one tendon are disclosed. A quantification of at least one property of a rotator cuff can be determined by using at least one artificial neural network and based on one or more medical images depicting the muscle structure of a patient.

The utility model discloses a simulation muscle structure for eliminating elastic return difference, which relates to the field of biological auxiliary tools, and comprises an action component, the action component comprises a simulation skeleton and a plurality of simulation tendons arranged along the axial direction of the simulation skeleton, a tendon driving unit communicated with the simulated tendon is arranged at one end of the simulated skeleton; the limiting assembly comprises a limiting protrusion which is arranged on the simulation skeleton and located at the free end, away from the tendon driving unit, of the simulation tendon, the free end of the simulation tendon is provided with an elastic tendon rope penetrating through the limiting protrusion, and the elastic tendon rope comprises a rigid material section and a flexible material section; and the elastic tendon rope is provided with a tendon rope limiting unit which moves along with the elastic tendon rope to approach the limiting bulge and is clamped with the limiting bulge. The rigid material section can reduce the working range of the elastic tendon rope and reduce the risk of length redundancy of the elastic tendon rope while ensuring the effective length of the elastic tendon rope, and the limiting assembly can prevent the elastic tendon rope from being excessively stretched.

Disclosed herein are systems and methods for testing effects of simulated microgravity on muscle structures. The system includes a clinostat and an adapter that is receivable into the clinostat. The adapter includes a housing that defines at least one receptacle. The system further includes an assembly having a substrate and a plurality of fibrils deposited on the substrate. The plurality of fibrils comprise collagen and extend along an axis. The assembly is receivable into a first receptacle of the at least one receptacle. The plurality of fibrils can have myoblasts thereon. Operation of the clinostat simulates microgravity. Test substances can screened using the muscle structures to determine effects on myogenesis.

The present application relates to the technical field of medicine, and provides application of strong loquat juice in preparation of a medicine for improving and / or treating muscle atrophy. The strong loquat juice is applied in preparation of the medicine for improving and / or treating muscle atrophy, in particular age-related muscle atrophy or inflammation factor-induced muscle atrophy, and the strong loquat juice improves and / or treats muscle atrophy by improving motor function, promoting myotube differentiation and hypertrophy, and maintaining muscle fiber structural integrity. The present application discloses the improvement effect of the strong loquat juice on muscle structure and function in cell and animal models: in a TNF-alpha-induced C2C12 myotube atrophy model, the strong loquat juice can significantly increase myotube diameter and improve myosin heavy chain expression; in an aging-related Caenorhabditis elegans model, the strong loquat juice can significantly enhance body bending ability, pharyngeal pump movement rate and muscle fiber structural integrity.

Disclosed herein are inhibitors of aminocarboxymuconate semialdehyde decarboxylase (ACMSD), pharmaceutical compositions and methods for using these compounds to treat or prevent one or more ACMSD-related diseases such as, for example, muscle structure disorders, neuronal activation disorders, muscle fatigue disorders, muscle mass disorders, beta oxidation diseases, metabolic diseases, cancer, vascular diseases, ocular vascular diseases, muscular eye diseases, liver diseases, inflammatory diseases or renal diseases.

Disclosed herein are aminocarboxymuconate-semialdehyde decarboxylase (ACMSD) inhibitors, pharmaceutical compositions, and methods of using these compounds to treat or prevent one or more ACMSD-related diseases, such as a muscle structural disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass abnormality disorder, a beta-oxidation disease, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, an ocular muscle disease, a liver disease, an inflammatory disease, or a kidney disease.

The invention discloses a bionic hip joint and a humanoid robot, the bionic hip joint comprises a hip bone connecting structure, a hip joint structure and a hip joint muscle structure, the hip bone connecting structure is used for connecting a bionic hip bone; one end of the hip joint structure is movably connected with the hip bone connecting structure; the hip joint muscle structure comprises a plurality of hip joint muscles distributed around the hip joint structure, each hip joint muscle comprises a pressure driving part and a flexible connecting part, the fixed end of the pressure driving part is connected with the hip joint structure, and the flexible connecting part is connected with the pressure driving part and the hip bone; the flexible connecting part is dragged through a hydrodynamic stretching mechanism of the pressure driving part, and the hip joint structure is driven to do joint movement relative to the hip bone; the flexible driving technology of the hydraulic muscles is adopted, the multiple hydraulic muscles can work cooperatively, multi-degree-of-freedom complex movement is achieved, and the design which is compact in space, high in connection reliability, low in power consumption and highly anthropomorphic is achieved.

The utility model provides a movable adjusting muscle structure of deep drawing die, including draw -out plate, muscle groove, movable drawing muscle and fixed part, the muscle groove is located on draw -out plate, the lower section of movable drawing muscle is inlayed in muscle groove and is fixed through fixed part, the utility model solves the problem that fixed drawing muscle cannot adjust according to the flow characteristic of different batches of materials, leads to the unstable quality of part and the problem of batch rejection, and does not need to replace draw -out plate as a whole, has saved the mould improvement cost, has improved production flexibility, has shortened mould debugging time.

Disclosed herein are inhibitors of aminocarboxymuconate semialdehyde decarboxylase (ACMSD), pharmaceutical compositions and methods for using these compounds to treat or prevent one or more ACMSD-related diseases such as, for example, muscle structure disorders, neuronal activation disorders, muscle fatigue disorders, muscle mass disorders, beta oxidation diseases, metabolic diseases, cancer, vascular diseases, ocular vascular diseases, muscular eye diseases, liver diseases, inflammatory diseases or renal diseases.

Provided herein are compositions comprising a thiazolium-based advanced glycation end product (AGE) breaker for use in methods to inhibit weight gain and associated muscle structural, functional, and performance deterioration induced by hyperglycemia. The thiazolium-based AGE breaker can be ALT-711.

Techniques of determining a quantification of at least one characteristic of a muscle structure comprising at least one muscle and at least one tendon are disclosed. The quantification of the at least one characteristic of the rotator cuff may be determined by using at least one artificial neural network and based on one or more medical images depicting the muscle structure of a patient.

The present invention provides a method and system for estimating ankle joint stiffness based on a skeletal muscle anatomical statistical model, belonging to the field of human mechanical impedance measurement. The method comprises: inputting preprocessed surface electromyographic signals into a muscle activation dynamics model to calculate muscle activation signals; inputting human limb characteristic parameters into a musculoskeletal statistical model to obtain muscle structure micro-parameters; calculating muscle force and muscle-tendon unit force at a specific muscle activation level using a muscle force solution model based on the muscle activation signals and muscle structure micro-parameters; calculating the stiffness of the muscle-tendon unit using a muscle-tendon unit stiffness model based on the muscle force and muscle structure micro-parameters; and calculating the joint stiffness using a muscle-tendon to joint mapping model based on the muscle-tendon unit force, muscle structure micro-parameters, and muscle-tendon unit stiffness. Compared with traditional stiffness identification and stiffness estimation methods, the present invention is more convenient, faster, and has higher accuracy.

The present disclosure relates to compositions comprising thiazolium-based AGE disruptors (advanced glycosylation end product disruptors) for use in methods of inhibiting weight gain and related muscle structure, function and performance degradation induced by hyperglycemia. The thiazolium-based AGE breaker can be an ALT-711 (Alpha Transferase Type 711).

The present invention relates to an artificial anal sphincter device with flexible clamping imitating puborectalis muscle, comprising a frame, an upper support ring, a flexible sleeve, a lower support ring, a control drive and a flexible rope, wherein an upper support frame and a lower support frame are horizontally arranged one above the other, a pair of fixed brackets are vertically arranged at intervals on the sides of the upper support frame and the lower support frame, the upper support frame and the lower support frame are respectively used to install the upper support ring and the lower support ring, the support ring comprises a left part and a right part of the support ring respectively arranged on the left and the right, the left part and the right part of the support ring are closed by buckles to form an arch, a channel for accommodating a supporting intestinal tube is formed between the support rings, the flexible sleeve is horizontally placed between the upper support ring and the lower support ring, and is installed by a fixed bracket, and the flexible rope connects the rotating shaft, the support ring and the flexible sleeve respectively. Compared with the prior art, the present invention realizes the structural design imitating puborectalis muscle and the flexible clamping of the intestinal tube tissue, avoids the complex mechanical structure design, and ensures the effectiveness and safety of the device.

The present invention discloses a method for analyzing muscle ultrasound images of model small animals, the method comprising: dividing the muscle ultrasound images of the model small animals into ROIs, and extracting muscle morphological features, image frequency features, and image texture features from the divided muscle ultrasound images; performing statistical analysis on the features to obtain statistically different features, and performing repeatability analysis based on test-retest reliability to obtain reliable features; according to the statistically different features and reliable features, obtaining an analysis model of the muscle ultrasound images; inputting the muscle ultrasound images of the model small animals to be analyzed into the analysis model of the muscle ultrasound images for analysis, and obtaining the detection and quantitative evaluation results of the muscle structure of the model small animals to be analyzed. The present invention can collect ultrasound images of the muscle parts of model small animals in vivo, and has the advantages of being non-invasive, simple and easy to implement, and can achieve fine detection and visualization of the muscle structure of living model small animals.

The utility model discloses a pump station pool structure which comprises a pool poured through a reinforcement cage structure, the reinforcement cage structure comprises a plurality of annular rib structures which are arranged up and down at intervals, and each annular rib structure comprises an outer annular rib and an inner annular rib which is concentrically arranged; a plurality of lock catch tie bars are fixedly connected between the outer ring rib and the inner ring rib; the outer ring rib and the inner ring rib are fixed and pulled through the lock catch pulling rib; the reinforcement cage structure further comprises a plurality of vertical lock catch ribs hung between the lock catch tie bars at the upper end and the lower end. Closed lock catch parts are arranged at the upper end and the lower end of the vertical lock catch rib, and the lock catch tie bars are limited in the lock catch parts; the pump station pool structure further comprises an anti-floating structure, and the anti-floating structure is welded to the bottom of the vertical lock catch rib. Through the structure, the structural strength of the water tank is improved in a reinforcement cage structure reinforcing mode, and then the requirement of a large water storage tank is met.

Disclosed herein are inhibitors of aminocarboxymuconate semialdehyde decarboxylase (ACMSD), pharmaceutical compositions and methods for using these compounds to treat or prevent one or more ACMSD-related diseases such as, for example, muscle structure disorders, neuronal activation disorders, muscle fatigue disorders, muscle mass disorders, beta oxidation diseases, metabolic diseases, cancer, vascular diseases, ocular vascular diseases, muscular eye diseases, liver diseases, inflammatory diseases or renal diseases.

The invention belongs to the field of freezing, and particularly relates to a cryoprotectant as well as a preparation method and application thereof. The cryopreservation protective agent comprises a permeable cryopreservation protective agent, a non-permeable cryopreservation protective agent, an antioxidant and equilibrium liquid; the zwitterionic betaine with good biocompatibility maintains osmotic pressure balance inside and outside tissues through free permeation; pVP and ice crystals form strong binding force, ice crystal recrystallization in the rewarming process is inhibited, meanwhile, protein is stabilized, and the integrity of the muscle structure is protected; d-panthenol reduces oxidative damage of muscles by inhibiting oxidative stress of the muscles in the cryopreservation process, and the activity and structure of protein in the muscles are protected.

The present invention relates to a drug containing botulinum toxin type A (BTX-A) and C3 transferase to be used in the treatment of muscle spasticity in cerebral palsy by chemical denervation method. While the structural and mechanical behavioral effects of BTX-A for the exposed muscles are contrary to the treatment goals; with its use together with C3 transferase, the treatment of spasticity, in which the negative effects on muscle structure and muscle mechanical behavior caused by BTX-A can be prevented, is effectively provided.

The subject invention pertains to compositions comprising a thiazolium-based advanced glycation end product (AGE) breaker for use in methods to inhibit weight gain and associated muscle structural, functional, and performance deterioration induced by hyperglycemia. The thiazolium-based AGE breaker can be ALT-711.

The invention belongs to the technical field of robots, and particularly relates to a bionic muscle structure-based facial expression driving system and method.The facial expression driving system comprises a flexible skin layer, a driving layer and a control system which are integrally formed; tendon simulation pieces are pre-buried in the muscle simulation area; drivers of the driving layer are intensively arranged in the robot head shell, pull the tendon simulation piece through a low-friction catheter and a transmission mechanism, drive the muscle simulation area to directionally deform and link the skin simulation area; the control system controls the driver by taking the expression unit as an object based on the facial action unit instruction library; the invention further discloses a robot applying the system and a manufacturing method of the flexible skin. The head structure is simplified, facial expressions with richer natural expressions are generated with less driving input, and the expression naturalness and the system stability are improved.

The invention discloses a ham producing and processing method, relates to the technical field of ham processing, and aims to solve the problem of unstable quality of ham products. According to the key points of the technical scheme, the method comprises the following steps: S1, selecting qualified pig hind legs, trimming to remove surface fat and connective tissues, retaining a complete muscle structure, and preparing a composite bioactive liquid required for pickling the pig hind legs, the composite bioactive liquid comprises a basic osmotic pressure regulation component, a flavor precursor orientation component, a microbial fermentation component and a cell physiological activity regulation component. Through a comprehensive process of programmable pressure-controlled rolling, staged fermentation and gradient dehydration ripening, a gradient dehydration program is adopted in the ripening stage, and the core water activity is predicted in real time through a water migration kinetic model, so that accurate end point judgment is realized, the product quality consistency is guaranteed, the resource waste is reduced, and the production cost is reduced. Finally, the ham product which is compact in texture, mellow in flavor, safe and stable is obtained.

The invention relates to the technical field of medical image analysis, in particular to a postpartum recovery evaluation system based on image analysis. The postpartum recovery evaluation system comprises an image partitioning module, a muscle parameter extraction module, a skin color difference measurement and calculation module, a region scoring module and a recovery trend prediction module. According to the method, region division is performed according to the spatial relationship of the key anatomical positioning points, and targeted image partition data is constructed, so that analysis of muscle structures and skin features can be accurately focused on functional recovery core parts such as the abdomen, the pelvis and the thigh, and the medical correlation of analysis data is enhanced. When muscle parameters are extracted, the density, thickness and contour area of muscle tissue are meticulously calculated in combination with continuous distribution of gray levels and edge form recognition, so that the quantitative precision of the muscle state is improved, and the recovery form of the tissue structure can be effectively revealed. The skin color difference analysis reduces the local color change rule and avoids the interference of the overall image deviation on the data at the same time.

A foil thrust air bearing imitating a whale stomatal muscle structure comprises a bearing base, a whale stomatal muscle-like bump foil structure and a flat foil, and the bearing base comprises an L-shaped mounting groove, an air supply hole I, an air supply hole II, a boss and a magnetic strip. The whale stomatal muscle-like bump foil structure comprises a magnetic attraction base, a bump foil structure air inlet guide pipe and a bump foil body, the flat foil comprises a foil plane and a foil buckle, and the whale stomatal muscle-like bump foil structure is characterized in that the L-shaped mounting grooves and the bosses are alternately and uniformly distributed on the bearing base in the circumferential direction, the air supply holes I are uniformly distributed on the bosses in the circumferential direction, and the air supply holes II are communicated with the bosses in the circumferential direction. The air supply holes II are evenly distributed in the two sides of the air supply hole I in the radial direction, the magnetic strips are located at outlets of the air supply holes II, the whale stomatal muscle-like bump foil structure is located on the bearing base, and the bump foil structure air inlet guide pipes are installed in the air supply holes II. The magnetic attraction base is located at the bottom end of the bump foil structure similar to the whale stomatal muscle and matched with the magnetic strip, the flat foil is located on the bump foil body, and the foil buckle is installed in the L-shaped installation groove.