Small-caliber artificial blood vessel with three-layer composite structure, and preparation method of small-caliber artificial blood vessel

Abstract

The invention provides a small-caliber artificial blood vessel with a three-layer composite structure, and a preparation method of the small-caliber artificial blood vessel. The small-caliber artificial blood vessel comprises a weaving inner layer, an electrostatic spinning intermediate layer and a polyurethane outer layer, wherein the electrostatic spinning intermediate layer is arranged on the outer side of the weaving inner layer; the polyurethane outer layer is arranged on the outer side of the electrostatic spinning intermediate layer; the weaving inner layer comprises a first weaving stand pipe and a second weaving bracket stand pipe; the second weaving stand pipe is a weaving stand pipe with axial yarns, and is arranged on the outer side of the first weaving stand pipe. The small-caliber artificial blood vessel adopts a simulation structure; the weaving stand pipes serve as enhancement layers and are relatively high in compliance; the electrostatic spinning intermediate layer adopts a precise three-dimensional reticular structure, so that coated drugs and growth factors are released step by step in the degradation process, thrombosis is prevented, and cell growth is facilitated; the polyurethane outer layer is relatively high in compliance and adopts a microporous structure, so that biomass transmission is facilitated; both PDO and PLLA are degradable materials, so that gradient degradation can be realized, the contact between the polyurethane material and blood can be reduced, the foreign-body reactions to the PDO and PLLA materials can be prevented, and the long-term patency rate can be improved.

Description

technical field [0001] The invention relates to the preparation of a small-diameter artificial blood vessel with a three-layer composite structure, which is characterized in that the artificial blood vessel with a composite structure designed by simulation has good compliance, the middle layer and the inner layer can be degraded in a gradient, reduces the long-term occurrence of thrombus, and improves the long-term patency rate . Background technique [0002] At present, artificial blood vessels are mainly made of polyester or expanded polytetrafluoroethylene through weaving or knitting, but there are problems in both materials and molding methods. Polyester material has poor hemocompatibility and is prone to thrombus and anastomotic intimal hyperplasia leading to blockage; expanded polytetrafluoroethylene is relatively hard and does not match the compliance of host blood vessels after implantation in the body, which can easily lead to intimal hyperplasia and stenosis. For ...

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problems of poor compliance of small-diameter artificial blood vessels and the existence of polyurethane artificial blood vessels at the present stage, to provide an artificial blood vessel with a three-layer composite structure, to promote the rapid growth of cells, and to resolve the contradiction between strength and compliance While avoiding polyurethane contact with blood

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