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Ion nitrogen injection method for vascular stent

A vascular stent and ion implantation technology, applied in the field of surface engineering technology and biological materials, can solve the problems of easy corrosion and safety doubts, and achieve the effect of enhancing corrosion resistance.

Inactive Publication Date: 2019-01-18
杭州联芳科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because metal biomaterials are prone to corrosion in physiological environments, especially toxic and carcinogenic nickel ions can be released from Nitinol alloys, which makes people doubt the safety of Nitinol alloys as long-term implant materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A vascular stent ion nitrogen injection method is characterized in that the following steps are adopted:

[0025] (1) The nickel-titanium alloy bracket is first polished with water-grinding paper to remove the initial roughness of the surface, then cleaned in acetone and deionized water, and dried to obtain a bright surface;

[0026] (2) Use anodic oxidation technology to remove nickel in nickel-titanium alloy;

[0027] (3) Ion cleaning;

[0028] (4) Nitrogen ion implantation.

Embodiment 2

[0030] Anodizing technology: 10% hydrogen peroxide, 0.5mol / L sodium chloride, PH=4.5, temperature 70 degrees Celsius. Use the water area furnace to carry out dealloying for 3 hours, take out the sample from the water area pot after dealloying, and obtain a certain thickness of nickel-free layer.

Embodiment 3

[0032] Ion implantation technology:

[0033] 1. Take off the discharge rod on the needle valve and place it in an easy-to-reach position on the left side of the chassis;

[0034] 2. Turn on the high-purity nitrogen, adjust the needle valve to the working pressure of (6~9)×10 -3 Pa;

[0035] 3. Turn on the control power supply, adjust the screen pole to 20KV, accelerate the voltage to 1KV, and adjust the anode voltage to 100V;

[0036] 4. Adjust the cathode to see if there is beam current. If there is no beam current, adjust the screen electrode to accelerate and anode to 0, turn off the power, and the discharge rod touches the needle valve to generate electric sparks, and then continue to the third step until beam current is generated;

[0037] 5. Generate beam current;

[0038] 6. The beam current is adjusted to 10Ma;

[0039] 7. The screen electrode is adjusted to 30KV, and the anode voltage is adjusted to 60V.

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Abstract

The invention belongs to the fields of surface engineering technologies and biomaterials and in particular relates to an ion nitrogen injection method for a vascular stent. In order to solve the technical problem, the invention provides the ion nitrogen injection method for the vascular stent. The ion nitrogen injection method is characterized by adopting the following steps: (1) firstly, sandinga nickel-titanium alloy stent by using waterproof abrasive paper to remove an initial rough state on the surface, and then, cleaning the nickel-titanium alloy stent in acetone and deionized water, andblow-drying the nickel-titanium alloy stent to obtain a bright surface; (2) removing nickel in nickel-titanium alloy by using an anodic oxidation technology; (3) carrying out ion cleaning; and (4) carrying out nitrogen ion implantation. The surface of the nickel-titanium alloy is treated, so that an ultrathin corrosion-resistant coating is formed on the surface; in addition, the coating cannot affect the stent and can be implanted into a body, so that the corrosion resistance of the stent is enhanced, and the Eb value is larger than or equal to 350 mv after potentiodynamic polarization experiments are completed.

Description

technical field [0001] The invention belongs to the field of surface engineering technology and biomaterials, in particular to a method for ion injection of nitrogen into blood vessel stents. Background technique [0002] The shape memory effect, superelasticity and high damping of nickel-titanium alloy shape memory alloy make it have advantages that traditional internal fixation materials cannot match. It has been used as vascular stent, esophageal stent, bone plate, intramedullary nail, tooth root, blood filter and artificial heart pump, etc. However, because metal biomaterials are prone to corrosion in physiological environments, especially toxic and carcinogenic nickel ions can be released from Nitinol alloys, people have doubts about the safety of Nitinol alloys as long-term implant materials. . Studies have shown that nickel-titanium alloy corrosion products have a toxic effect on cells. The higher the concentration of corrosion products, the greater the effect of in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/48
CPCC23C14/48
Inventor 丁红
Owner 杭州联芳科技有限公司
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