Polyamide 66 membrane covered nickel-titanium alloy intravascular scaffold and preparation method thereof

A technology of vascular stent and nickel-titanium alloy, which is applied in the field of vascular stent material and its preparation, to achieve the effects of good impact toughness, stable structure, and good forming and processing performance

Inactive Publication Date: 2010-05-12
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a polyamide 66 (PA66) coated nickel-titanium alloy vascular stent and its preparation method. The prepared vascular stent has a stable structure, good mechanical action, transportability, and anti-seepage Leakage, can be used as a leak-trapping vascular stent to prevent hemangioma rupture, the preparation method combines the characteristics of existing vascular stents, overcomes the lack of performance of a single material, and the preparation process is simple

Method used

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  • Polyamide 66 membrane covered nickel-titanium alloy intravascular scaffold and preparation method thereof
  • Polyamide 66 membrane covered nickel-titanium alloy intravascular scaffold and preparation method thereof

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Embodiment 1

[0025] Dissolve PA66 in formic acid with a concentration of 90% to make a PA66 solution with a concentration of 6wt%; coat the resulting PA66 solution on a glass rod with a diameter of 15mm several times, and place it at a temperature of 65°C to evaporate the solvent Form the inner PA66 film of the vascular stent; put the nickel-titanium shape memory alloy expansion stent evenly on the glass rod coated with the PA66 film; again coat the glass rod with PA66 solution multiple times, and place it at a temperature of 65°C The solvent was volatilized to form the outer PA66 film of the stent; the covered stent was peeled off from the glass rod, and the PA66 covered stent was obtained after vacuuming at 60°C for 5 hours to remove the residual solvent.

Embodiment 2

[0027] Dissolve PA66 in formic acid with a concentration of 92% to make a PA66 solution with a concentration of 9wt%; coat the resulting PA66 solution on a glass rod with a diameter of 25mm in several times, and place it at a temperature of 70°C to evaporate the solvent Form the inner PA66 film of the vascular stent; put the nickel-titanium shape memory alloy expansion stent evenly on the glass rod coated with the PA66 film; again coat the glass rod with PA66 solution multiple times, and place it at a temperature of 70°C The solvent was volatilized to form the outer PA66 film of the stent; the covered stent was peeled off from the glass rod, and the PA66 covered stent was obtained after vacuuming at 60°C for 5 hours to remove the residual solvent.

Embodiment 3

[0029] Dissolve PA66 in formic acid with a concentration of 95% to make a PA66 solution with a concentration of 12wt%; coat the resulting PA66 solution on a glass rod with a diameter of 35mm several times, and place it at a temperature of 75°C to evaporate the solvent Form the inner PA66 film of the vascular stent; put the nickel-titanium shape memory alloy expansion stent evenly on the glass rod coated with the PA66 film; again coat the glass rod with PA66 solution multiple times, and place it at a temperature of 75°C The solvent was volatilized to form the outer PA66 film of the stent; the covered stent was peeled off from the glass rod, and the PA66 covered stent was obtained after vacuuming at 70° C. for 5 hours to remove the residual solvent.

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Abstract

The invention relates to a polyamide 66 membrane covered nickel-titanium alloy intravascular scaffold and a preparation method thereof. The intravascular scaffold comprises a nickel-titanium alloy scaffold and a polyamide 66 membrane, and is provided with a tubular blood vessel shaped structure or a cylindrical blood vessel shaped structure, wherein the surfaces of an inner wall and an outer wallof the scaffold are covered by thin membranes with the thickness between 0.2 and 5 millimeters. The preparation method comprises the following steps of: preparing 1 to 20 percent of polyamide 66 solution by using formic acid as a solvent; coating a layer of the polyamide 66 solution on a glass rod and volatizing the solvent; sleeving a nickel-titanium shape memory alloy expanding scaffold on the glass rod; coating another layer of the polyamide 66 solution on the glass rod and volatizing the solvent; and peeling off the polyamide 66 membrane and the nickel-titanium alloy intravascular scaffold from the glass rod, and performing vacuum drying to obtain the polyamide 66 membrane covered intravascular scaffold. The intravascular scaffold prepared by the method has a stable structure, good mechanical property, transportability and anti-seepage property, overcomes the performance defects of a single material, and has a simple preparation process.

Description

technical field [0001] The invention belongs to the field of vascular stent materials and preparation thereof, in particular to a polyamide 66 coated nickel-titanium alloy vascular stent and a preparation method thereof. Background technique [0002] In daily life, the loss, damage or failure of human tissues and organs is very common, which poses a serious threat to people's health and life. For a long time, people have been exploring and researching materials and biotechnology, with the purpose of solving relevant problems in medicine, ensuring human health, and serving the prevention, diagnosis, treatment and rehabilitation of diseases. [0003] Tumors arising from vascular tissue are called hemangiomas, 80% of which are congenital. If it grows on the face or the surrounding skin, there is no other harm except affecting the appearance; if it is a hepatic hemangioma, if the hemangioma is large, it will affect the digestive function, and the rupture of the hemangioma will ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02B05D7/14
Inventor 杨庆赵婧时翠红郯志清沈新元
Owner DONGHUA UNIV
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