Low-surface-energy anti-adhesion nickel-titanium wire and processing method thereof

A technology with low surface energy and processing methods, applied in the field of medical devices, can solve problems such as susceptibility to infection, granulation hyperplasia, protein adhesion, etc., and achieve the effect of avoiding blockage and infection problems, and avoiding introduction

Pending Publication Date: 2021-11-05
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of granulation hyperplasia, protein adhesion and susceptibility to existing nickel-titanium alloy wire braided stents. Nickel-titanium alloy wire with infection function and processing method thereof

Method used

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  • Low-surface-energy anti-adhesion nickel-titanium wire and processing method thereof
  • Low-surface-energy anti-adhesion nickel-titanium wire and processing method thereof
  • Low-surface-energy anti-adhesion nickel-titanium wire and processing method thereof

Examples

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Effect test

Embodiment 1

[0020] In this example, a pulsed laser processing method was used to prepare a micro-nano structure with anti-fibroblast adhesion, anti-protein adhesion and anti-infection functions on the surface of nickel-titanium wire. The specific steps are as follows:

[0021] Fix a nickel-titanium wire with a diameter of 0.4mm and a length of 1m, and apply force at both ends to straighten the nickel-titanium wire so that the laser spot is irradiated on the surface of the nickel-titanium wire. The laser processing technology is: pulse energy 800μJ, laser scanning speed 1mm / s, spot size 100μm, laser scanning line spacing 80μm. The laser spot scans once along the axial direction of the nickel-titanium wire, the nickel-titanium wire rotates 15° around the axis, the laser spot scans again along the axial direction, and so on, scanning the entire surface of the nickel-titanium wire. The processed surface micro-nano structure such as figure 1 Shown, where a, b are the first-order and second-or...

Embodiment 2

[0046] In this example, a micro-nano structure with anti-fibroblast adhesion, anti-protein adhesion and anti-infection functions was prepared on the surface of nickel-titanium wire by two pulse laser processing, the specific steps are as follows:

[0047] Fix a nickel-titanium wire with a diameter of 0.6mm and a length of 0.5m, and apply force at both ends to straighten the nickel-titanium wire so that the laser spot is irradiated on the surface of the nickel-titanium wire. The laser processing technology is: pulse energy 600μJ, laser scanning speed 2mm / s, spot size 80μm, laser scanning line spacing 50μm. The laser spot scans once along the axial direction of the nickel-titanium wire, the nickel-titanium wire rotates 30° around the axis, the laser spot scans again along the axial direction, and so on, scanning the entire surface of the nickel-titanium wire. The processed structure is a primary structure, which is micron protrusions with a size of about 6 μm and a height of abo...

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Abstract

The invention relates to a nickel-titanium wire with an anti-adhesion function and a processing method of the nickel-titanium wire. A two-stage micro-nano composite structure is manufactured on the surface of the nickel-titanium wire; the first-stage structure is a micron-stage array protrusion structure; the second-stage structure is a nano-stage protrusion structure; and the second-stage structure is distributed on the surface of the first-stage structure. The micro-nano structure is prepared on the surface of the nickel-titanium alloy wire through a pulse laser processing method, so that the surface of the nickel-titanium alloy wire is endowed with the functions of resisting fibroblast adhesion, resisting protein adhesion and resisting infection, and the problems of blockage and infection after the nickel-titanium alloy stent woven by the nickel-titanium wire is implanted can be effectively solved. And meanwhile, the pulse laser processing technology only relates to physical processing, so that introduction of a chemical coating is avoided.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a nickel-titanium alloy wire, in particular to a nickel-titanium alloy wire with an anti-adhesion function and a processing method thereof. Background technique [0002] Many diseases can lead to stenosis and obstruction of human lumens such as blood vessels, colon, biliary tract, urethra, esophagus, trachea, etc. Clinically, such diseases are often solved by implanting stents in the stenosis of the lumen. Nickel-titanium alloy has superelasticity, low elastic modulus, shape memory effect, and good biocompatibility, so it is used to prepare self-expanding stents suitable for various luminal stenosis, such as cardiovascular stents, peripheral vascular stents, Intracranial stent, esophageal stent, biliary stent, tracheal stent and urethral stent, etc. [0003] With the deepening of clinical practice, more and more attention has been paid to endowing the surface of nickel-titanium al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B23K26/352B23K26/082B23K26/70B23K103/18
CPCB23K26/352B23K26/082B23K26/702B23K2103/18
Inventor 梁春永邹显睿王洪水王东辉周欢
Owner HEBEI UNIV OF TECH
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