Nickel titanium oxide coated articles

A product and coating technology, applied in the field of nickel-titanium oxide-coated products, can solve the problems of affecting endothelial cells, reducing endothelial cells, increasing the risk of thrombosis, etc.

Inactive Publication Date: 2017-02-22
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, antiproliferative drugs in DES are nonspecific and also affect endothelial cells (EC), leading to delayed healing and increased rates of late stent thrombosis
Specifically, drugs such as Paclitaxel and Rapamycin are known to increase the risk of thrombosis by reducing the function, proliferation and migration of endothelial cells

Method used

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  • Nickel titanium oxide coated articles
  • Nickel titanium oxide coated articles
  • Nickel titanium oxide coated articles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0122] Example 11 Extraction of nickel ions from articles and substrates

[0123] In this example, the leaching of nickel ions from the article prepared in Example 1 and a nickel-titanium alloy foil purchased from Alfa Aesar was determined. Approximately 1 cm x approximately 1 cm samples of articles and substrates were submerged in tissue culture plates and placed under standard tissue culture conditions (approximately 37°C, approximately 5% CO 2 and approximately 95% humidity), tissue culture plates contained approximately 1 ml of phosphate-buffered saline (PBS) solution in a standard 24-well tissue culture plate. Approximately 1 ml of PBS samples were withdrawn at specific time points and replaced with fresh PBS solutions. These PBS samples were then tested using the Nickel Assay Kit (Sigma-Aldrich, cat# MAK027) according to the manufacturer's instructions.

[0124] Figure 15 The results shown in indicate that the nickel release rate was higher for the article including ...

Embodiment 12

[0127] Example 12 Migration of endothelial cells on the surface of an article comprising a nickel-titanium-oxide coating.

[0128] In this example, the re-endothelialization potential of an article comprising a coating of a complex of nickel, titanium and oxygen was determined by quantifying the migration of primary human aortic endothelial cells (HAEC) on the coated surface.

[0129] Since the process of stent deployment causes exfoliation of the endothelial layer, re-endothelialization is one of the key factors in the prevention of restenosis and thrombosis, as disclosed, for example, in the following publication: "Biological Effects of Drug-Eluting Stents in Steffel et al. the Coronary Circulation” Herz 2007, 32, 268–273; “The Effect of TiO 2 Nanotubes on Endothelial Function and Smooth MuscleProliferation" Biomaterials 2009,30,1268–1272; Peng's "Whole Genome Expression Analysis Reveals Differential Effects of TiO 2 Nanotubes on Vascular Cells" NanoLett. 2010, 10, 143–148;...

Embodiment 13

[0133] Example 13 Expansion and proliferation of endothelial cells on the surface of an article comprising a nickel-titanium-oxide coating.

[0134] In this example, the endothelial cell expansion and proliferation potential of an article comprising a coating of a complex of nickel, titanium and oxygen was determined. Such a test may be another type of test to determine the re-endothelialization potential of an article.

[0135] In this example, a preparation prepared in the same manner as described in Example 1 was used. The cell expansion and proliferation potential of HAEC on the surface of bare Nitinol foil (ie control or substrate) purchased from Alfa Aesar was also investigated similarly. HAEC used in this example was manufactured by Lonza (USA). Cells were maintained and grown according to the manufacturer's instructions and all experiments were performed with cells between passage number 3 and 7.

[0136] Under sterile conditions, samples were sterilized with ethano...

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Abstract

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a Nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may improve re-endothelialization and / or reduce restenosis when it is used in the treatment of cardiovascular diseases.

Description

[0001] Cross References to Related Applications [0002] This application is based on, and claims priority to, US Provisional Patent Application 62 / 016,455, filed June 24, 2014, entitled "Nickel-Titanium Oxide Coated Articles." The entire content of this application is incorporated herein by reference. technical field [0003] The present disclosure relates to articles comprising at least one substrate and at least one porous coating formed on the at least one substrate. The present disclosure specifically relates to medical articles. The present disclosure also relates to porous coatings comprising compounds of nickel, titanium and oxygen. The present disclosure further relates to porous coatings comprising tubular structures. Background technique [0004] Heart disease imposes a huge burden on patients and is estimated to cost more than $316 billion in the United States in 2010 alone, the majority of which was spent on coronary heart disease. A large number of these pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04C23C28/00C25D7/04C25D11/02
CPCA61F2002/0086A61L31/022A61L31/082A61L31/146A61L2400/12C25D11/34A61F2/0077A61F2/82A61L31/088A61L2400/18A61L2420/02
Inventor T·A·德塞P·P·李
Owner RGT UNIV OF CALIFORNIA
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