Patents
Literature
13 results about "Microfilament" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Microfilaments, also called actin filaments, are filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton and are primarily composed of polymers of actin, but in cells are modified by and interact with numerous other proteins. Microfilaments are usually about 7 nm in diameter and composed of two strands of actin. Microfilament functions include cytokinesis, amoeboid movement and cell motility in general, changes in cell shape, endocytosis and exocytosis, cell contractility and mechanical stability. Microfilaments are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton tensile forces. In inducing cell motility, one end of the actin filament elongates while the other end contracts, presumably by myosin II molecular motors. Additionally, they function as part of actomyosin-driven contractile molecular motors, wherein the thin filaments serve as tensile platforms for myosin's ATP-dependent pulling action in muscle contraction and pseudopod advancement. Microfilaments have a tough, flexible framework which helps the cell in movement.
Multi-scale artificial dermal scaffold and preparation method thereof
The invention discloses a multi-scale artificial dermal scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering and biomedical materials. The artificial dermal scaffold is of a three-dimensional porous structure formed by microfilaments of a first frame and a second frame, the microfilaments of the second frame are distributed in pores of the first frame, disordered microfilaments which do not affect the penetrability of the macropores are arranged in the macropores in the top surface of the first frame, and longitudinally aligned microfilaments are arranged in the micropores in the section of the first frame. Through the specific structure, the adhesion, proliferation and migration effects of cells can be remarkably improved, and rapid vascularization of artificial dermis is facilitated. In addition, the preparation process of the artificial dermal scaffold is simple and easy to operate, can be used for batch preparation, and has a good application prospect.
Owner:NOVAPRINT THERAPEUTICS SUZHOU CO LTD
Gradient degradation type personalized absorbable sternum fracture fixing plate and preparation process
The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.
Owner:ZHANGZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE FUJIAN PROVINCE
DEVICE FOR INTRODUCING MICROFILAMENTS INTO SOFT TISSUE
Owner:NEURONANO AB
Absorbent composite web containing a highly porous layer and particles mixed with continuous microfilaments.
The present invention relates to an absorbent composite web in which particles mixed with continuous microfilaments are arranged within the pores of a high-loft web, and to a method for forming the web, the web being applicable to filtration applications or (particularly when the particles are liquid absorbent particles) to absorbent hygiene products.
Owner:ザンポッロファビオ
Compound for FBXO44 inhibitor, composition and application thereof
PendingCN121850962AEnhanced inhibitory effectPotent anti-proliferative effectOrganic chemistryAntineoplastic agentsPharmaceutical SubstancesTumor cells
The invention discloses a polysubstituted amine compound, a pharmaceutical composition containing the polysubstituted amine compound and an application of the polysubstituted amine compound in tumor resistance. The structure of the polysubstituted amine compound is shown as a formula I in the specification. Through multiple experiments, the inventor of the invention proves that the compound disclosed by the invention has a remarkable inhibiting effect on FBXO44, and can be combined with the FBXO44 in cells to inhibit down-regulation of the FBXO44 on MTSS1, so that the formation of tumor cell microfilament skeletons is disturbed, and the compound has a strong anti-proliferation effect on gastric cancer cell strains such as NUGC4 and the like. Therefore, the compound disclosed by the invention can be used as an FBXO44 inhibitor to be applied to medicines for treating solid tumors or leukemia related to human or animal cell proliferation.
Owner:ZHEJIANG UNIV +1
3, 4, 5-trihydroxy phenylacetate compound as well as preparation method and application thereof
PendingCN121895166AOrganic compound preparationCarboxylic acid nitrile preparationMelanomaSquamous Carcinomas
The invention relates to a 3, 4, 5-trihydroxy phenylacetate compound and a preparation method and application thereof, the 3, 4, 5-trihydroxy phenylacetate compound belongs to a compound shown in a general formula I and a general formula II, R1, R2 and corresponding derivatives thereof can activate a copper death pathway mediated by endogenous copper ions, have an obvious anti-tumor effect, and have a stronger anti-tumor effect in chemotherapy of drug-resistant tumors. The tumors comprise melanoma, liver cancer, gastric cancer, breast cancer, oral squamous cell carcinoma and the like. The compound is a non-copper ion carrier compound with a brand new structure, induced copper death does not depend on exogenous copper ions, and endogenous copper ions are dissociated by reducing the content of glutathione which is a copper ion chelate in cells. The copper ions are further combined with microfilament skeleton related protein to cause disintegration of the microfilament skeleton, so that copper death is induced. The compound disclosed by the invention can be used as a potential lead compound for inducing endogenous copper ion mediated copper death for anti-tumor therapy.
Owner:XIAMEN UNIV
Menstrual blood-derived mesenchymal stem cell ovarian targeting complex and preparation method thereof
The application provides a blood-derived mesenchymal stem cell ovary targeting complex and a preparation method thereof. The ternary gel matrix system of the application is composed of sodium hyaluronate, four-arm polyethylene glycol maleimide and mercapto carboxymethyl dextran in the second precursor solution, a thioether bond crosslinking network is formed in situ through a maleimide-mercapto Michael addition reaction, and ovarian decellularized extracellular matrix microfilaments are introduced as a biomimetic support unit, and the blood-derived mesenchymal stem cells are encapsulated into injectable microtissue unit preparations with an arithmetic mean of 150-800 mu m and a particle size variation coefficient of not more than 15% through a microfluidic device. The application realizes the synergistic optimization of the injectable fluidity of the gel matrix and the rapid forming stability in the body, significantly improves the cell viability protection effect and the microtissue unit batch particle size uniformity, and solves the technical contradiction that the injectability and structural stability cannot be considered in the existing injectable cell preparations.
Owner:GUANGZHOU XIAOMANYAO MEDICAL INSTR CO LTD +1
An implantable bioelectrode with a structure similar to a cuscuta haustorial structure and a preparation method thereof
The application provides an implantable bioelectrode with a structure simulating a Cuscuta suction organ and a preparation method thereof, and relates to the technical field of medical devices. The implantable bioelectrode comprises an electrode substrate and a biomimetic interface coating arranged on the surface of the electrode substrate; the biomimetic interface coating comprises, from inside to outside, a conductive buffer layer, an imitated invasive microfilament layer and a tissue adhesion layer. The implantable bioelectrode utilizes the synergistic effect of the three-layer biomimetic interface to improve the connection stability. The outer adhesion film provides rapid and non-invasive in-situ fixation, the middle nanowire array realizes minimally invasive probe-type anchoring, and the inner hydrogel provides mechanical buffering and eliminates modulus mismatch. The structure effectively overcomes the interface wear and signal attenuation caused by physiological micro-motion, and realizes long-term, stable and low-impedance adhesion.
Owner:SHENZHEN BAK POWER BATTERY CO LTD
Construction method and application of cell robot for enhancing cell therapy targeting and entity penetration
PendingCN121846296APharmaceutical delivery mechanismPharmaceutical non-active ingredientsSolid tissueCell therapy
The invention relates to the technical field of cell targeted therapy, in particular to a construction method and application of a cell robot for enhancing cell therapy targeting and entity penetration. The invention relates to a construction method of a cell robot for enhancing cell therapy targeting and entity penetration. The construction method comprises the following steps: coupling magnetic microfilaments on the surfaces of cells; the magnetic microfilament comprises a microfilament and magnetic particles attached to the microfilament; and the microfilaments are made of polylactic acid-glycolic acid copolymer. According to the technical scheme, the technical problem that in the prior art, chimeric antigen receptor modified macrophages with high targeting and penetrating capacity are lacked can be solved, and the technical problems that in the prior art, chimeric antigen receptor cells generally face infiltration of solid tissues and infiltration is not ideal are further solved. The engineering cell design combining the bionic sperm model and magnetic driving breaks through the bottleneck of the traditional cell therapy in solid tissue delivery, provides a brand new technical thought and method for wider cell therapy optimization, and has ideal application and popularization values.
Owner:ARMY MEDICAL UNIV
A cytoskeleton modeling method based on dissipative particle dynamics simulation
ActiveCN115641917BComputational theoretical chemistryChemical machine learningCell regionCytoskeletal Modeling
The application provides a cytoskeleton modeling method based on dissipative particle dynamics simulation, comprising the following steps: step 1, setting a cell region in a dissipative particle dynamics simulation software; step 2, randomly distributing microfilament single chains which do not intersect each other in the cell region; step 3, randomly generating a plurality of free cross-linking protein particles in the cell region; step 4, the microfilament single chains and the cross-linking protein particles are polymerized / dissociated until the number of the cross-linking protein particles in three states tends to be stable, the three states of the cross-linking protein particles are free, combined with only one microfilament single chain and combined with two microfilament single chains; step 5, deleting the cross-linking protein particles and directly connecting two microfilament single chains connected by the same cross-linking protein particle; and step 6, calculating cytoskeleton parameters and outputting a cytoskeleton model. The cytoskeleton constructed by the application has high fidelity and presents mechanical characteristics such as viscoelasticity under the action of an external force.
Owner:NANKAI UNIV
Use of imperata cylindrica ferment for promoting collagen proliferation and method for manufacturing imperata cylindrica ferment
ActiveCN111184822BYeast food ingredientsDermatological disorderHyaluronic acid synthaseStratum corneum structure
The present application relates to the use of a plant fermentation product, in particular the use of a Imperata cylindra fermentation product for increasing the expression of genes, promoting the proliferation of collagen and elastin, and increasing the antioxidant capacity. The present application provides an Imperata cylindra fermentation product prepared by two-stage fermentation of an Imperata cylindra water extract with yeast and lactobacillus. The present application also provides the use of an Imperata cylindra fermentation product for preparing a composition for increasing the expression of keratin gene, polykeratin microfilament gene and hyaluronic acid synthase gene, promoting the proliferation of collagen and elastin, and increasing the antioxidant capacity. The Imperata cylindra fermentation product can effectively increase the skin moisturizing capacity, maintain the arrangement of keratinocytes, maintain the integrity of the stratum corneum structure, improve the skin barrier function, make the skin firm and elastic, and prevent skin aging.
Owner:TCI CO LTD(CN)
High-precision grinding and polishing clamp for microfilament sample column end face positioning and modular quick change
The invention discloses a high-precision grinding and polishing clamp for microfilament sample column end face positioning and modular quick change, and belongs to the technical field of electron microscope sample preparation. The invention discloses a high-precision grinding and polishing clamp for microfilament sample column end face positioning and modular quick change. The high-precision grinding and polishing clamp comprises a clamping base, a microfilament positioning module and an end face gland. According to the invention, the problems of poor clamping stability, low positioning precision, easy damage of samples, low operation efficiency and incapability of batch processing of microwires with the diameter of 10-100 [mu] m in the existing clamping technology are solved, and controllable vertical pre-tightening force is applied by the end face gland to realize high-precision coplanar positioning of the end faces of the microwires; flexible lossless constraint on the side face is achieved through a stepped micropore array with a micro-texture inner wall or a V-shaped groove array with a flexible liner, and efficient, lossless, batched and repeatable high-quality preparation of microfilament samples is achieved through modular quick-change design and a high-precision repeated positioning interface.
Owner:CHONGQING UNIV
Treatment method for secondary sedimentation tank float sludge initiated by DCM control agent in sulfate process pulping
The invention relates to the field of sewage treatment, in particular to a treatment method for secondary sedimentation tank float sludge initiated by a DCM control agent in sulfate pulping. The method comprises a step of adding a fusion protein as shown in SEQ ID NO.3 into a secondary sedimentation tank, and further comprises the following steps: regulating the concentration of dissolved oxygen to 2.0-4.0 mg / L, the temperature to 35-40 DEG C and the pH value to 6.8-7.2, hydrolyzing extracellular proteins or extracellular polysaccharides generated by various zoogloea bacteria in the secondary sedimentation tank, destroying a foam skeleton and reducing adhesion of microhyphae, thereby realizing the purpose of removing the microhyphae in the secondary sedimentation tank. And the problem of'combined action of a DCM control agent and filamentous bacteria 'is solved, and the problem of float sludge in a secondary sedimentation tank is solved.
Owner:ASIA SYMBOL SHANDONG PULP & PAPER