160 results about "Microfilament" patented technology

An intravascular stent having a prefabricated, patterned polymeric sleeve for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel is disclosed. The polymeric sleeve is attached to at least a portion of an outside surface area of the stent structure. Alternatively, a plurality of individual microfilament strands are longitudinally attached to an outer surface of a stent structure in a spaced apart orientation and loaded with at least one therapeutic drug for the release thereof at a treatment site. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. Methods for making the same are also disclosed.

The invention relates to a preparation method of recycled polyester chip microfilaments and a usage thereof, belonging to the field of plastic modification and category of composite material/alloy promoter. The polyester chip microfilament is an ideal promoter which has excellent performance, environment-friendliness, high added value, wide application range and broad market prospect and can change the mechanical property of the composite material/alloy. Recycled blow molding polyester (RPET/RPBT) is taken as main raw material, and the following formula and process are adopted for preparing the microfilament according to parts by weight: 100 parts of recycled polyester (RPET/RPBT), 5-30 parts of wire-drawing high-density polyethylene (HDPE)/ polypropylene (PP)/ linear low-density polyethylene (LLDPE), 0.1-4 parts of crosslinking agent/ chain extender/anchoring agent, 0.1-0.8 part of antioxidant, 0.5-6 parts of nucleating agent, and 1-5 parts of nucleate accelerant, and other processing aids (such as lubricant and plasticizer)/functional aids (such as fire retardant and ultraviolet absorber) can be additionally and appropriately added. The microfilament is prepared through extrusion, cooling, drawing and granulating by the reaction under 90-260 DEG C under the action of mechanical shear. The recycled polyester (RPET/RPBT) microfilament prepared in the invention can endow the composite material/alloy with excellent mechanical property.

An apparatus, system and method to provide increasingly fine gradient density depth filtration of a fluid. The apparatus may include a melt-blown filtration assembly having varying densities of melt-blown microfilaments fabricated from acetal or other substantially dimensionally stable thermoplastic. The apparatus thus facilitates efficient filtration by providing a gradient density depth filtration system compatible with various fuels, coolants, and other forms of a fluid.

Microfilament-generating multicomponent fibers are provided that include a first polymer component and a second polymer component extruded together in separate contiguous polymer segments extending along the length of the fiber. The first polymer component comprises a synthetic melt-processable polymer that is substantially soluble in a first relatively benign solvent selected from water, aqueous caustic solution, and non-halogenated organic solvents. The second polymer component is formed from a second synthetic melt-processable polymer dimensioned to produce one or more microfilaments upon dissolution of the first polymer, and that is substantially soluble in an aqueous solvent selected from water and aqueous caustic solution. The two polymer components are dissolvable in different solvents.

The invention discloses a three-dimensional porous cartilage extracellular matrix sponge scaffold made of natural cartilage, which can compound cells further to construct tissue engineered cartilage, and can be used for clinically repairing cartilage defects. In the invention, conditions which can fully perform cell extraction and form a porous scaffold matrix are provided by processing cartilage into cartilage microfilaments, and then the cell extraction and solidification and/or strengthening treatment are performed to obtain the three-dimensional porous cartilage extracellular matrix sponge scaffold which is completely decellurized. The antigenicity and cell components are removed in the natural cartilage, and an extracellular matrix component of the cartilage is retained to obtain the scaffold with appropriate pore diameter and porosity, suitable degradation rate, good biocompatibility and certain biomechanical strength. The scaffold has the advantages of broad material sources, low cost, simple and feasible preparation technology, and good repetitiveness; and the scaffold can be widely applied in the field of tissue engineering and has good clinical application prospect.

The invention discloses a tissue engineering bone/cartilage double-layer scaffold and a construction method and application in medical science. The method adopts natural cartilage and bone as materials, respectively removes the antigenicity of the cartilage and the bone through de-cell, and adopts a freezing and drying method to prepare the double-layer scaffold simultaneously suitable for growthof the two issues of the bone and the cartilage. A preparation method comprises that: acellular bone is soaked in suspension of cartilage acellular matrix microfilaments, and the double-layer scaffoldof which the upper layer is a cartilage acellular matrix three-dimensional porous spongy scaffold and the lower layer is an acellular bone scaffold is prepared by the freezing and drying method and acrosslinking method. The cartilage acellular matrix spongy scaffold part of the double-layer scaffold can be introduced with factors promoting the formation of the cartilage, and the acellular bone part can be introduced with factors promoting the formation of the bone, and the factors can be respectively inoculated with cells for forming the cartilage or the bone to construct a living tissue engineering bone/cartilage complex, which is used for repairing bone and cartilage complex defect or total joint defect clinically.

A mattress or mattress overlay is provided, which is formed from several layers of spacer fabric. At least two layers of the spacer fabric are arranged such that the microfilaments in the layers curve in the same direction, towards the foot of the bed. Another layer can be provided, with layers which curve in the same, or a different direction, e.g. orthogonal. The top layer is more compressible than the bottom layer and the surface of the top layer of spacer fabric is provided with cuts in the heel region to reduce pressure at this high-risk bony prominence.

An automotive tufted carpet with improved acoustic properties is formed with a two-part primary backing. The first backing layer is formed of a woven or non-woven material, and the second backing layer is formed of a microfilament spunlaced material possessing sound absorbing acoustic properties. The first backing layer and second backing layer are thermobonded together with an adhesive web positioned therebetween to form the two-part primary backing. Tufts of yarn are then sewn through the two-part primary backing. The resulting acoustically enhanced automotive tufted carpet may be backcoated or precoated, and may have a secondary backing adhered thereto as a matter of choice.

The invention relates to a construction method for in-vitro three-dimensional human liver tissue. The construction method comprises the following steps: (1) uniformly mixing a solution of seed cells with an aqueous solution of biological ink so as to obtain a cell printing solution; (2) under the control of a computer, uniformly extruding the cell printing solution with a cell printer at a set speed according to a designed path and allowing the cell printing solution to rapidly coagulate at a certain temperature so as to form gel microfilaments, and repeating the above operations so as to finish construction of a multilayer cell structure in a layer-upon-layer scanning manner; (3) subjecting the multilayer cell structure to secondary crosslinking and culturing the multilayer cell structure with a cell culture solution so as to obtain a stable multilayer cell structure; and (4) culturing the stable multilayer cell structure with an induction medium so as to obtain the in-vitro three-dimensional human liver tissue. The method provided by the invention can construct in-vitro three-dimensional human liver tissue with good functionality, and the constructed in-vitro three-dimensional human liver tissue is applicable to fields like treatment of hepatopathy, medicinal development, medicine screening, etc.

Method of and apparatus for continuously manufacturing highly oriented super micro filaments with a diameter of 5 μm or less from most of thermoplastic polymers stably by a simple and convenient means without requiring any special apparatus of high accuracy and high level, characterized in original filaments supplied from a filament supply means are heated by infrared beams and the heated filaments are drawn by tension provided by their own weight or under an applied tension of 1 MPa or less, and are drawn to 1000 times or more.

A device and a method are disclosed, by means of which microfilament yarns made of synthetic polymers can be produced with increased uniformity of the titer, dye absorption and improved physical yarn properties at increased production speeds by means of a spinning process with spinnerets of high hole density and a central cooling unit.

The present invention provides a method and a dedicated chip for preparation of micron calcium alginate filaments based on a microfluidic chip. By using the chip and the method, calcium alginate microfilament with a minimum diameter of 20 [mu]m can be prepared, calcium alginate microfilaments interiorly including a dispersed phase of spherical structure of other materials can be prepared, and calcium alginate microfilaments with special morphology can be prepared. By using an independent fluid path and a gas path control system of the microfluidic chip, combined with a micro-injection pump and a gas pump valve system, the diameter of the calcium alginate microfilaments can be controlled; the material dispersed phase with the special structure in the microfilaments, including pitch, size, composition and sequence, can be highly-controlled arranged; and the special structure of the filaments can be adjusted. The method and the platform provided by the present invention can highly-controlled prepare calcium alginate filaments, the preparation process is stable, and morphology of the product is homogeneous, and the method is simple.

The object of this invention is to make possible the manufacturing of sheath-core type super microfilaments from sheath-core type filaments such as hollow filaments, optical filaments and conjugate filaments continuously and stably by a simple and convenient means without requiring any apparatus of high-accuracy and high-level, characterized in that original filaments delivered from sheath-core type filament supply means are heated by infrared beams and the heated sheath-core type filaments are drawn at 100 times or more by a tension provided by the own weight or under a tension of 1 MPa or less.

The invention discloses preparation and application of a nerve tissue matrix derived tissue engineering scaffold material. A nerve tissue is taken as a raw material, matrix components (including nano-scale collagen microfilaments, fibronectin microfilaments and laminin microfilaments) favorable for nerve regeneration are extracted by means of medicine expansion, mechanical pulverization, enzymolysis treatment, dialysis collection and the like, and immunogenicity components (including Schwann cells, phospholipid and axons) not favorable for nerve regeneration are removed. The prepared nerve tissue matrix derived material can be further prepared into a three-dimensional porous oriented scaffold through oriented crystallization, freeze drying and crosslinking separately or by matching other polymer materials, or is prepared into a nano-scale film by an electrospinning technology, and the film is wound to form a nerve regeneration catheter. The tissue engineering scaffold or catheter prepared by the method is favorable for adhesion, proliferation and migration of seed cells, promotes nerve generation and can be used for never defect repair.

Provided is a stent graft that has superior prevention of endoleakage due to being resistant to creasing, and has superior prevention of graft migration as a result of promoting cell infiltration into gaps among microfibers in a dispersed state and forming an integrated structure with the cells in the landing zone of the stent. The stent graft according to the present invention is a stent graft comprising a stent graft fabric that has microfiber bundles consisting essentially of microfilaments having a filament linear density of 0.5 dtex or less, and said microfiber bundles having a total linear density of 10 to 60 dtex/120 to 3000 filaments, for the warp and/or weft, and in which the porosity of the microfiber bundles is 30% to 95%, wherein said stent graft has said stent graft fabric being located in at least 1 cm range from the central end.

The objective of the present invention is to enable a microfilament that is a nanofilament to be manufactured continuously and consistently from all thermoplastic polymers without requiring a specialized high precision.high performance apparatus and also to present the nanofilament manufactured as described. The present invention comprises a microfilament in a nanofilament region and the manufacturing means thereof wherein a original filament transferred using a filament transfer means is supplied to an orifice under pressure P1 and is heated and drawn using an infrared light beam directly under the orifice under pressure P2 (P1>P2).

The invention relates to the field of making biochips, in particular to a preparation method of an agarose gel microfluidic device. Particularly, the agarose gel microfluidic device is prepared by three steps of assigning microfilaments, pouring and solidifying, and wiredrawing. The agarose gel microfluidic device manufactured by the method has good sealing property, and the recovery rate of liquid is up to 95%. The agarose gel microfluidic device manufactured by the method can generate stable concentration gradients, and is used for observing interaction between cells and biochemical micro-environments, especially the interaction under a flow condition. The method has simple operation, and the microfluidic device can be manufactured in an ordinary lab without expensive precision instruments.

The invention discloses a labeling method of an apple pollen tube microfilament. The labeling method comprises the following steps: cultivating apple pollen, curing the apple pollen, performing enzyme treatment on the apple pollen, treating the apple pollen with a surfactant, performing dye labeling, and performing scanning and imaging. The labeling method has the beneficial effect that the labeling method of gymnosperm pollen tube microfilament is referred and improved on the basis of the labeling method of pear pollen tube microfilament, dyes enter cells easier through curing, enzymolysis of cell walls and the surfactant, the interference of cell outer wall autofluorescence due to insufficient enzymolysis as TRITC-Phalloidin is applied are avoided when FITC-Phalloidin labeling is applied, so that relatively complete apple pollen tube microfilament can be stored; moreover, the labeling method is efficient and quick, can be used for obtaining relatively clear and bright pictures, thus filling up the blank of the apple pollen tube microfilament labeling, providing reference for labeling microfilament in rosaceae and angiosperm pollen tube, and achieving a high application value.

The invention discloses a tissue engineering nerve graft with a suspension fiber scaffold. The nerve graft comprises a conduit and tube fiber scaffolds. The nerve graft is characterized in that a plurality of suspensions are arranged on each fiber scaffold along the fiber length direction, and are connected with the inner wall of the conduit; and the fiber scaffolds are distributed and suspended in the conduit by virtue of the suspensions. By utilizing bio-printing technology, built-in microfilaments of a tissue engineering nerve graft can be stably and uniformly distributed in the conduit by utilizing the supporting force of the suspensions, and each fiber scaffold has an independent space to guarantee that nerve cells can directionally grow along the fiber scaffolds and cannot have error bridging, so that the success rate of operations can be greatly improved.

The invention discloses a rat-intracranial-implantation microfilament array electrode suitable for an experiment and a manufacturing method thereof. The electrode is formed by a plurality of electrode microfilaments, a dosing conduit and the like. The electrode microfilaments are arranged in parallel and form a microfilament measurement electrode array and a microfilament stimulation electrode array respectively. The electrode manufactured through using the method of the invention can simultaneously realize three functions of experiment rat brain electric signal recording, electrical stimulation and drug stimulation. According to a specific demand, one or any two functions can be selected. And self-manufacturing can be completed with low cost.

The invention discloses a flexible hair sensor based on ferromagnetic microfilaments and applications thereof, and belongs to the field of sensors. The invention aims to solve the problem of current hair sensors that current hair sensors often have rigid and complex structures and also have limited application fields that the current hair sensors can only test non-contact flow velocity and can not conduct direct test on contact stress or vibration. The flexible hair sensor includes ferromagnetic microfilaments and coils, wherein the ferromagnetic microfilaments serve as a flexible sensing unit the structure of which is composed of two rows of ferromagnetic microfilament arrays which are in crossed arrangement and two coils. The two coils are wound around the distal ends of the ferromagnetic microfilament arrays with a certain number of turns, one coil serving as an excitation end and the other coil serving as a detection end. According to the invention, the flexible hair sensor adopts the sensing theory of electromagnetic induction in testing deformation occurred to the ferromagnetic microfilaments, has high sensitivity and adjustable measuring range. For the detection of external signals, the flexible hair sensor can realize adjustment of sensitivity and measuring range, can be widely applied to the detection of gas wind speed, liquid flow velocity and vibration signal, and has great potential.