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2 results about "Microfilament" patented technology
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Microfilaments, also called actin filaments, are filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton and are primarily composed of polymers of actin, but in cells are modified by and interact with numerous other proteins. Microfilaments are usually about 7 nm in diameter and composed of two strands of actin. Microfilament functions include cytokinesis, amoeboid movement and cell motility in general, changes in cell shape, endocytosis and exocytosis, cell contractility and mechanical stability. Microfilaments are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton tensile forces. In inducing cell motility, one end of the actin filament elongates while the other end contracts, presumably by myosin II molecular motors. Additionally, they function as part of actomyosin-driven contractile molecular motors, wherein the thin filaments serve as tensile platforms for myosin's ATP-dependent pulling action in muscle contraction and pseudopod advancement. Microfilaments have a tough, flexible framework which helps the cell in movement.
Menstrual blood-derived mesenchymal stem cell ovarian targeting complex and preparation method thereof
The application provides a blood-derived mesenchymal stem cell ovary targeting complex and a preparation method thereof. The ternary gel matrix system of the application is composed of sodium hyaluronate, four-arm polyethylene glycol maleimide and mercapto carboxymethyl dextran in the second precursor solution, a thioether bond crosslinking network is formed in situ through a maleimide-mercapto Michael addition reaction, and ovarian decellularized extracellular matrix microfilaments are introduced as a biomimetic support unit, and the blood-derived mesenchymal stem cells are encapsulated into injectable microtissue unit preparations with an arithmetic mean of 150-800 mu m and a particle size variation coefficient of not more than 15% through a microfluidic device. The application realizes the synergistic optimization of the injectable fluidity of the gel matrix and the rapid forming stability in the body, significantly improves the cell viability protection effect and the microtissue unit batch particle size uniformity, and solves the technical contradiction that the injectability and structural stability cannot be considered in the existing injectable cell preparations.
Owner:GUANGZHOU XIAOMANYAO MEDICAL INSTR CO LTD +1
An implantable bioelectrode with a structure similar to a cuscuta haustorial structure and a preparation method thereof
The application provides an implantable bioelectrode with a structure simulating a Cuscuta suction organ and a preparation method thereof, and relates to the technical field of medical devices. The implantable bioelectrode comprises an electrode substrate and a biomimetic interface coating arranged on the surface of the electrode substrate; the biomimetic interface coating comprises, from inside to outside, a conductive buffer layer, an imitated invasive microfilament layer and a tissue adhesion layer. The implantable bioelectrode utilizes the synergistic effect of the three-layer biomimetic interface to improve the connection stability. The outer adhesion film provides rapid and non-invasive in-situ fixation, the middle nanowire array realizes minimally invasive probe-type anchoring, and the inner hydrogel provides mechanical buffering and eliminates modulus mismatch. The structure effectively overcomes the interface wear and signal attenuation caused by physiological micro-motion, and realizes long-term, stable and low-impedance adhesion.
Owner:SHENZHEN BAK POWER BATTERY CO LTD