Construction method of micro point array in microchannel

A construction method and micro-channel technology, which are applied in the field of processing of micro-channels and their internal micro-dot arrays to achieve the direct effect of patterning

Inactive Publication Date: 2008-10-01
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Obviously, in view of the traditional technical inertia in the existing process, there are many deficiencies in the methods disclosed in the above-mentioned documents for the manufacturing approach of closely combining micro-channels and micro-dot arrays, and the application fields of related technologies are urgently needed Develop a form of technology that better combines the performance of microfluidics with the advantages of high-throughput microarrays

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  • Construction method of micro point array in microchannel
  • Construction method of micro point array in microchannel
  • Construction method of micro point array in microchannel

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Such as Figure 1 to Figure 6 As shown, the process of constructing the micro-dot array in the planar micro-channel array according to the method of the present invention is described. The specific instructions are as follows:

[0037] The first step, cross wiring: such as figure 1 and figure 2 As shown, on the upper surface 3 of the substrate 2 with the recessed structure 1 in the center, the first kind of microwires 4 are arranged and fixed with a pitch of 90 microns along one direction to form the first microwire array 5, and the first microwire arrays 5 are arranged along the other direction. The second type of microwire 6 is laid out to form the second microwire array 7; the first microwire array 5 and the second microwire array 7 are intersected in pairs, and each intersection has a contact point 8. Then, press the cover sheet 10 with the through hole 9 in the center on the upper surface 3 of the base 2, so that the crossed first microwires formed by the first...

Embodiment 2

[0045] Such as Figure 7 As shown, this figure has described the micro-dot array in the single microchannel that is made by technical approach of the present invention. On the plexiglass substrate 2 upper surface 3 with rectangular groove (or recessed structure 1), arrange the nylon silk thread (as the II microfilament 6) of a diameter 40 microns along one direction and fix, on the other Dozens of platinum wires with a diameter of 20 microns (as the first kind of microwire 4) are arranged in parallel with a 10 micron pitch in the direction and fixed, and then the rectangular channel with the same size as the above-mentioned rectangular groove (or recessed structure 1) is passed The plexiglass cover sheet 10 of the hole 9 is covered on the base 2 and the groove 1 is aligned with the through hole 2 for fixing.

[0046] Proportion PDMS prepolymer and curing agent in a weight ratio of 10:1, mix evenly, place in a vacuum pump tank for about 40 minutes to remove the air in the poly...

Embodiment 3

[0049] Such as Figure 8 and Figure 9As shown, the two figures describe the processing and formation of rectangular micro-dot arrays in micro-channels according to the technical approach of the present invention. Take stainless steel microwires with the same rectangular cross-section (i.e. the first microwire 4 and the second microwire 6), arrange them in an orthogonal array (i.e. form the first microwire array 5 and the second microwire array 7) and arrange them Fix it on the plexiglass substrate 2; take the cover sheet 10 and align it with the corresponding concave part on the substrate 2 and fix it, pour PDMS, and solidify, such as Figure 8 Shown in; After solidification, take out the II microwire array 7 arranged on top, promptly form the microdot array 15 in the microchannel 14, the shape of its point is a rectangle, and the length is the length of the I microwire 4 arranged below Width, the width is the width of the second kind of microfilament 6 arranged on top, as ...

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Abstract

The invention provides a method for establishing a micro-point array in a micro-channel which relates to the technical field of processing of micro-channels. In the method, the main steps of arrangement, casting, etc. are adopted to cure microfilament arrays contacted in a cross manner in polymer and then the steps of demoulding, filament removal, etc. are adopted to entirely form micro-points or micro-point arrays in the micro-channel. The method of the invention is based on a molding process belonging to the soft lithography category without relying on a costly and stringent photoetching process; in addition, the method can also flexibly and differently create various surfaces, geometric shapes and sizes of different micro-point materials in different micro-flowing channels through combining and arranging material composition, geometric shapes and sizes of the crossed filaments, which results in that basic technical types of the micro-flowing and the micro-array can be closely integrated as a whole to provide a flexible and low-cost processing and manufacturing approach for the integration of the techniques of micro-fluidic control and micro-solid control.

Description

Technical field: [0001] The invention relates to the technical field of microchannel processing, in particular to a processing method for a microchannel and an internal microdot array. Background technique: [0002] In the open literature, in order to adapt to various applications, some technical approaches or clues for the possible combination of microchannels and microdot arrays have been proposed. For example, US Patent 20070116607 published May 24, 2007 [Wang, William X.; Yi, Jun; Ke, Sheng; Halmela, Maria; Lahteenmaki, Pertti; Kihara, Kazuma: Microsystems that integrate three-dimensional microarray and multi-layer Microfluidics for combinatorial detection of bioagent at single molecule level] The technology described tries to integrate microfluidic components with microarray components. Obviously, this can also greatly promote the efficiency of microarray processing, but this disclosed technology It is only an interface between the separately manufactured microfluidic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C39/02B01L3/00B81B1/00B81C1/00G01N33/00C12M1/00C12Q1/00
CPCG01N33/54386
Inventor 蒋家欢贾月飞李远宋国立吴云鹏
Owner CHONGQING UNIV
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