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Magnetic sodium cantharidinate vitamin B6 compound preparation and preparation method thereof

A technology of sodium cantharidinate and compound preparations, which is applied in the direction of medical formulations, organic active ingredients, and medical preparations of non-active ingredients.

Active Publication Date: 2015-08-05
GUIZHOU BAIQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For the problems existing at present, the invention provides a kind of magnetic sodium cantharidinate vitamin B6 compound preparation and preparation method thereof, the magnetic Fe 3 o 4 Add it into sodium cantharidate to make magnetic sodium cantharidate liposome, then add vitamin B6 to make magnetic sodium cantharidate vitamin B6 compound preparation, which can give full play to the antitumor activity of sodium cantharidate and reduce toxic and side effects, and promote the growth of sodium cantharidate in clinical application

Method used

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  • Magnetic sodium cantharidinate vitamin B6 compound preparation and preparation method thereof
  • Magnetic sodium cantharidinate vitamin B6 compound preparation and preparation method thereof
  • Magnetic sodium cantharidinate vitamin B6 compound preparation and preparation method thereof

Examples

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Embodiment 1

[0086] A magnetic sodium cantharidate vitamin B6 injection is prepared from 50 parts of magnetic sodium cantharidate liposome and 1 part of vitamin B6 in parts by weight.

[0087] Wherein, the magnetic sodium cantharidate liposome is made of the following materials by weight: 1 part of sodium cantharidate, magnetic Fe 3 o 4 1 part, 5 parts of egg yolk lecithin, 1 part of cholesterol and 50 parts of water.

[0088] The preparation method of aforementioned magnetic sodium cantharidinate vitamin B6 injection comprises the following steps:

[0089] (1) Magnetic Fe 3 o 4 preparation of

[0090] Fe 2+ +2Fe 3+ +8OH - =Fe 3 o 4 +4H 2 o

[0091] Referring to the Molday titration hydrolysis method, the FeCl 3 and FeSO 4 Mix and dissolve in water for injection according to the molar ratio of 2:1, and use 1.5mol / L NH 4 OH aqueous solution to adjust the pH value to 8.0 to obtain black Fe 3 o 4 suspension. Place the suspension on a magnet to induce magnetic Fe 3 o 4 Preci...

Embodiment 2

[0099] A magnetic sodium cantharidate vitamin B6 injection is prepared in parts by weight from 100 parts of magnetic sodium cantharidate liposome and 3 parts of vitamin B6.

[0100] Wherein, the magnetic sodium cantharidinate liposome is made of the following materials by weight: 5 parts of sodium cantharidinate, magnetic Fe 3 o 4 2 parts, 10 parts of soybean lecithin, 3 parts of cholesterol, 1 part of sodium deoxycholate and 100 parts of water.

[0101] The preparation method of aforementioned magnetic sodium cantharidinate vitamin B6 injection comprises the following steps:

[0102] (1) Magnetic Fe 3 o 4 preparation of

[0103] Fe 2+ +2Fe 3+ +8OH - =Fe 3 o 4 +4H 2 o

[0104] Referring to the Molday titration hydrolysis method, the FeCl 3 and FeSO 4 Mix and dissolve in water for injection according to the molar ratio of 2:1, and use 1.5mol / L NH 4 OH aqueous solution to adjust the pH value to 8.0 to obtain black Fe 3 o 4 suspension. Place the suspension on a m...

Embodiment 3

[0112] A magnetic sodium cantharidate vitamin B6 injection is prepared in parts by weight from 200 parts of magnetic sodium cantharidate liposome and 5 parts of vitamin B6.

[0113] Wherein, the magnetic sodium cantharidate liposome is made of the following materials by weight: 15 parts of sodium cantharidinate, magnetic Fe 3 o 4 3 parts, dipalmitoylphosphatidylcholine 15 parts, cholesterol 2 parts, sodium deoxycholate 2 parts and water 200 parts.

[0114] The preparation method of aforementioned magnetic sodium cantharidinate vitamin B6 injection comprises the following steps:

[0115] (1) Magnetic Fe 3 o 4 preparation of

[0116] Fe 2+ +2Fe 3+ +8OH - =Fe 3 o 4 +4H 2 o

[0117] Referring to the Molday titration hydrolysis method, the FeCl 3 and FeSO 4 Mix and dissolve in water for injection according to the molar ratio of 2:1, and use 1.5mol / L NH 4 OH aqueous solution to adjust the pH value to 8.0 to obtain black Fe 3 o 4 suspension. Place the suspension on a...

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Abstract

The present invention discloses a magnetic sodium cantharidinate vitamin B6 compound preparation and a preparation method thereof, wherein the magnetic sodium cantharidinate vitamin B6 compound preparation is prepared from 50-300 parts by weight of magnetic sodium cantharidinate liposome and 1-10 parts by weight of vitamin B6, wherein the magnetic sodium cantharidinate liposome is prepared from 1-20 parts of sodium cantharidinate, 1-5 parts of magnetic Fe3O4, 5-20 parts of phospholipid, 1-5 parts of cholesterol, 0-2 parts of sodium deoxycholate, and 50-300 parts of water. The preparation method comprises: preparing magnetic Fe3O4, preparing a magnetic sodium cantharidinate solution, preparing a magnetic liposome suspension, adding vitamin B6, dissolving, adding water for injection to carry out volume metering, and finally preparing the injection or freeze-drying powder. The prepared magnetic sodium cantharidinate vitamin B6 compound preparation of the present invention has effects of reduction of irritation on blood vessels, improvement of medication safety, reduction of toxic-side effect, and improvement of drug stability.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and in particular relates to a magnetic sodium cantharidate vitamin B6 compound preparation and a preparation method thereof. technical background [0002] The incidence and mortality of malignant tumors are increasing year by year. According to the "2012 China Tumor Registration Annual Report", the number of new malignant lung tumors in my country is about 3.2 million every year, and the number of deaths due to malignant tumors is about 2.7 million, which has surpassed Cardiovascular and cerebrovascular diseases have become the leading cause of death. [0003] Sodium cantharidinate is a semi-synthetic derivative of the active ingredient of the traditional anticancer insect drug cantharidin. Sodium cantharidinate changes tumor cell morphology and function by inhibiting tumor cell protein and nucleic acid synthesis, reducing tumor cell cyclic adenosine monophosphate phosphodiesterase activity,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4415A61K9/127A61K47/04A61K47/24A61P35/00A61K31/34
Inventor 张沛崔杏
Owner GUIZHOU BAIQIANG PHARMA
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