A kind of clarithromycin ion pair liposome injection and preparation method thereof
A technology of clarithromycin and liposome, which is applied in the field of preparing clarithromycin ion-pair liposome injection, can solve the problems of clarithromycin irritation, poor water solubility, and difficulty in development, etc. Reduced toxicity, reduced pain and vascular irritation effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0100] Example 1 Formula 1 clarithromycin content 250mg: 100ml
[0101] Based on 100ml injection
[0102]
[0103]
[0104] The rest is water for injection;
[0105] Preparation of clarithromycin ion-pair liposome injection:
[0106] Step 1: Na 2 HPO 4 12H 2 O0.29g, NaH 2 PO 4 2H 2 O0.13g, KH 2 PO 4 Disperse 0.02g, 0.8g of NaCl, and 0.02g of KCl in 100mL of water for injection, dissolve them all, and prepare the water phase, keep it warm at 60°C for later use;
[0107] Step 2: Dissolve egg yolk lecithin 4.5g, clarithromycin 0.25g, cholesterol succinate monoester 0.325g, and MPEG-DSPE 0.5g with an appropriate amount of absolute ethanol, remove the ethanol by rotary evaporation, and blow dry with nitrogen; The phospholipid dry film was hydrated with the aqueous phase prepared in step 1 at 60°C for 30 minutes to obtain the clarithromycin liposome coarse dispersion system, which was set aside;
[0108] Step 3: Transfer the liposome coarse dispersion system to a hi...
Embodiment 2
[0111] Example 2 Formula 2 clarithromycin content 100mg: 100ml;
[0112] Based on 100ml injection
[0113]
[0114] The rest is water for injection;
[0115] Preparation of clarithromycin ion-pair liposome injection:
[0116] Step 1: Na 2 HPO 4 12H 2 O0.29g, NaH 2 PO 4 2H 2 O0.13g, KH 2 PO 4 Disperse 0.02g, 0.8g of NaCl, and 0.02g of KCl in 100mL of water for injection, dissolve them all, and prepare the water phase, keep it warm at 60°C for later use;
[0117] Step 2: Dissolve egg yolk lecithin 4.5g, clarithromycin 0.1g, cholesterol succinate monoester 0.13g, and MPEG-DSPE 0.5g with an appropriate amount of absolute ethanol, remove the ethanol by rotary evaporation, and blow dry with nitrogen; The phospholipid dry film was hydrated with the aqueous phase prepared in step 1 at 60°C for 30 minutes to obtain the clarithromycin liposome coarse dispersion system, which was set aside;
[0118] Step 3: Transfer the liposome coarse dispersion system to a high-pressure h...
Embodiment 3
[0121] Example 3 Formula 3 clarithromycin content 500mg: 100ml
[0122] Based on 100ml injection
[0123]
[0124] The rest is water for injection;
[0125] Preparation of clarithromycin ion-pair liposome injection:
[0126] Step 1: Na 2 HPO 4 12H 2 O0.29g, NaH 2 PO 4 2H 2 O0.13g, KH 2 PO 4 Disperse 0.02g, 0.8g of NaCl, and 0.02g of KCl in 100mL of water for injection, dissolve them all, and prepare the water phase, keep it warm at 60°C for later use;
[0127] Step 2: Dissolve egg yolk lecithin 4.5g, clarithromycin 0.5g, cholesterol succinate monoester 0.65g, and MPEG-DSPE 0.5g with an appropriate amount of absolute ethanol, remove the ethanol by rotary evaporation, and blow dry with nitrogen; The phospholipid dry film was hydrated with the aqueous phase prepared in step 1 at 60°C for 30 minutes to obtain the clarithromycin liposome coarse dispersion system, which was set aside;
[0128] Step 3: Transfer the liposome coarse dispersion system to a high-pressure homo...
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
particle diameter | aaaaa | aaaaa |
encapsulation rate | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com