Medicinal composition containing 4-hydroxy-2-oxo-1-pyrrolidine acetamide and application thereof

Abstract

The invention belongs to the technical field of medicinal products, and particularly relates to a medicinal composition containing 4-hydroxy-2-oxo-1-pyrrolidine acetamide and application thereof. A 4-hydroxy-2-oxo-1-pyrrolidine acetamide-borneol medicinal composition provided by the invention has a synergistic treatment effect on neuromotor dysfunction and impaired memory dysfunction vascular dementia and senile dementia, and the treatment effect of oxiracetam can be improved remarkably by using borneol, so that the acting dose of oxiracetam is reduced, the dosage is reduced, and adverse reactions are reduced after long-time application. By adopting the medicinal composition, intelligence disturbance of a dementia patient can be treated more effectively, and a treatment effect can be achieved with a small dosage. The medicinal composition is suitable for clinical use.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing 4-hydroxy-2-oxo-1-pyrrolidineacetamide and its application. Background technique [0002] Dementia is an acquired intelligence impairment syndrome with cognitive impairment as the core symptom. Cognitive impairment may involve functions such as memory, learning, orientation, comprehension, judgment, calculation, language, and visual space. The degree of intellectual impairment is sufficient Interference with activities of daily living or socio-occupational functioning. Dementia includes degenerative diseases and non-degenerative diseases. The former includes Alzheimer's disease (Alzheimer, AD) and dementia with Lewy bodies, and the latter includes vascular dementia (VD). AD, also known as senile dementia, is a neurological disease with memory and cognitive dysfunction as the main clinical manifestation and progressive a...

AI Technical Summary

Problems solved by technology

In addition, since the lower limit of D-borneol content in natural borneol is 96%, it still contains a certain amount of impurities, which may affect the safety of medication. Therefore, people have purified natural borneol, and currently there are commercially available products with a purity of ≥98%. (+)-2-borneol

[0012] The Pharmacopoeia stipulates that the daily dose of borneol is 150-300 mg per day. Taking large doses of borneol may cause gastrointestinal adverse reactions such as heartburn, nausea, abdominal pain, and vomiting.

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