43results about How to "Avoid ingestion" patented technology

The invention relates to the field of specific molecular identification and diagnosis reagent and in particular discloses a near infrared fluorescent dye with structural formulas I and II; and the invention also discloses a near infrared molecular probe which is obtained through covalent bonding between the near infrared fluorescent dye with the structural formulas I and II and a ligand of specific molecules. The near infrared molecular probe can be used for early diagnosis of turmour diseases.

The invention belongs to the field of biotechnology, and relates to a slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system, and a preparation method thereof. The slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system is prepared via self-assembly of a slightly acidic environment targeted polypeptide modified dendrimer encapsulated gene, wherein the surface of the dendrimer is rich of amino groups. According to the preparation method, a polypeptide of transmembrane helix protein C derived from bacteria visual purple is used for modifying a high molecular carrier, enrichment and adhesion onto cells is realized via a pH sensitive cell membrane insertion method, and entering into cells is realized via electrostatic adsorption guided endocytosis, so that untaking of tumor cells on drugs is improved, and toxic and side effects are reduced. According to the tumor targeted nano drug delivery system, cell membrane is taken as the target point, and the polypeptide is taken as the target head group in tumor slightly acidic environment, targeting and curing efficiency are high, the preparation method is simple and convenient, and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.

The invention belongs to the technical field of medicine, and designs and synthesizes a series of disulfide bond-containing micromolecular prodrugs in which carbon chains in different lengths are linked (sulfur atoms in the disulfide bond are respectively located alpha, beta and gamma sites of an ester bond). PTX (Paclitaxel)-CIT (Citronellol) is used as a sample, and a synthesis method is simpleand easy. On the basis, a micromolecular prodrug self-assembly nano-drug delivery system is prepared. The preparation method is simple and convenient, the stability is high, and efficient encapsulation and delivery of drugs are realized. The invention discovers that the disulfide bond has redox dual sensitivity, can be fractured under the action of high-expression ROS (Reactive Oxygen Species) andGSH (Glutathione) of tumor cells, and PTX can be released; particularly, redox dual hypersensitivity is shown by PTX-CIT prodrugs (alpha-PTX-SS-CIT), which are located in the alpha site of a carbonylgroup, of the disulfide bond, the alpha-PTX-SS-CIT prodrugs can be quickly fractured to release the PTX and take effects, an anti-tumor effect of the PTX is remarkably improved, and a wide development prospect is obtained.

Compositions containing ketone bodies and/or metabolic precursors thereof suitable for administration to humans and animals, which are characterized by (i) enhancing cardiac performance, especially the efficiency of the heart in utilizing glucose, (ii) providing energy, especially is to provide energy in diabetes and insulin resistance, (iii) to treat conditions caused by brain cell damage, especially by delaying or preventing brain damage in memory-related areas of the brain, such as in Alzheimer's disease and Brain damage found in brains with similar conditions. These compositions can be used as nutritional supplements, for example for athletes, or for the treatment of diseases, especially disorders related to cardiac insufficiency, insulin resistance and neuronal damage. The invention also provides methods of treatment as well as novel esters and polymers for inclusion in the compositions of the invention.

A gas turbine combustion system has a combustion system wall delimiting a flow path for hot and pressurized combustion gas and at least one resonator with a resonator volume. The resonator volume is delimited by resonator walls, where one of the resonator walls is located adjacent to or is formed by the combustion system wall. The resonator has at least one cooling fluid supply opening which is open towards a cooling fluid source. It further has a neck opening which is open towards the flow path and which is implemented in the form of a neck slot.

The invention discloses a photographing method and a photographing device. The photographing method comprises the steps of acquiring one or more consecutive frames of a preview image of a to-be-photographed scene; detecting whether the one or more consecutive frames have preset features; if yes, controlling a camera to photograph the to-be-photographed scene. Through adoption of the photographing method, the problem caused by the fact that the content displayed by a displayer is easy to photograph in the prior art is solved, so that data shown by the displayer is prevented from being taken and revealed, and the data are better protected.

The invention belongs to the technical field of medicines and relates to a photosensitizer-hypoxia activated prodrug integrated prodrug. According to the invention, a photosensitizer and a hypoxia activated prodrug are connected through a bond which breaks under triggering by photo-induced electron transfer, a bond sensitive to active oxygen, or a bond which breaks under the triggering by photo-induced electron transfer and is sensitive or non-sensitive to active oxygen, so the photosensitizer and the hypoxia activated prodrug can be efficiently co-loaded and synchronously delivered. Pyropheophorbide a is used as a photosensitizer, PR104A is used as a hypoxia activated prodrug, a thioketal bond or monothioether bond or non-sensitive carbonate bond is employed for connecting pyropheophorbide with PR104A to synthesize an integrated prodrug, and then a self-assembled nanometer drug delivery system is prepared. According to the invention, a preparation process is simple; the drug loading capacity of the nanoparticles is high; the particle size of the nanoparticles is small and uniform, so the nanoparticles can be enriched at a tumor part through an EPR effect; while photodynamic therapy is conducted, the selective release of the hypoxia activated prodrug in the tumor is triggered through dual modes of PET and ROS; and the photodynamic therapy promotes the activation of the hypoxiaactivated prodrug, and significantly improves the synergistic anti-tumor effect of the photosensitizer and the hypoxia activated prodrug.

The invention relates to the technical field of polymer materials, and particularly relates to preparation and application of a mixed structure PLGA-PLL-PEG (Polylactide Acid Glycolic Acid-Polylysine-Polyethylene Glycol) targeting polymer carrier. The preparation is characterized in that polylactide acid glycolic acid and side chain protected polylysine are acted by a dehydrating agent and then connected in the block way to form a midbody; the midbody is deprotected and then connected with activated polyethylene glycol in the grafting manner, so that the polylactide acid glycolic acid-polylysine-polyethylene glycol polymer having the molecular weight of 4*10 <4> to the power of 4 to 5*10<5> is obtained. The polymer is used for carrying various medicines and also capable of being coupled with various ligands to realize targeted medicine delivery. The preparation of the polymer carrier provided by the invention is few in synthesis steps, mild in reaction conditions, available in materials and convenient for product purification.

The invention discloses medicine carrying polymer micelle which is methyl polyethylene glycol polylactic acid segmented copolymer micelle carried with hydrophobicity drugs; the grain size is 50-100nm, and the dispersion coefficient PI of the grains is more than or equal to 0.05 and is less than or equal to 0.09; the invention further discloses a preparation method of the medicine carrying polymer micelle; the grain size of the medicine carrying polymer micelle is small, the grain size distribution range is centralized, the stability is good, and the in vitro releasing experiment and the in vitro macrophagocyte cytophagy experiment can reach good effect. The preparation method of the medicine carrying polymer micelle has the following characteristics: the operation is simple and convenient; the encapsulating rate is high, and the highest encapsulating rate can be up to more than 90%; in addition, the prepared medicine carrying polymer micelle has good performance.

The invention discloses a feed additive for reducing the cholesterol content in eggs and a preparation method thereof. Cholesterol has an important physiological function in animal body, is an important component of various mode structures of cells and nerve myelin sheath, and is a precursor for synthesizing bile, steroid hormone and vitamin D3; however, excessively high cholesterol concentration in blood causes high blood fat and a series of consequent cardiovascular diseases such as atherosclerosis, high blood pressure, coronary heart disease and the like. The feed additive disclosed by the invention comprises the following components in parts by weight: 16.35-18.25 parts of curcumin, 0.02-0.03 part of brochantite, 12.36-15.85 parts of hawthorn, 22.35-25.68 parts of safflower seed oil and 42.00-46.00 parts of natural red yeast rice. The feed additive disclosed by the invention is used for reducing the cholesterol content in eggs.

The invention provides a barrier-free soup-adding hot pot, and relates to an intelligent hot pot. The intelligent hot pot comprises a table body, a heating device, a pot body, a rotating mechanism, anautomatic oil tank system, an automatic soup system, a lifting mechanism, an upper cover body and the like, wherein the table body comprises a table panel and a bottom plate; the center of the tablepanel is hollowed-out; the heating device is mounted at the hollowed-out position; the pot body is placed on the heating device; the heating device and the pot body are annular; the automatic oil tanksystem and the automatic soup system are mounted on the bottom plate; and the output end of the automatic oil tank system successively penetrates through the hollowed-out position of the table panel,the central hole of the heating device and the pot wall of the inner side of the pot body and extends to the position above a cavity of the pot body. Soup and edible oil can be added automatically, the space of the table body does not need to be occupied, the hot pot does not hinders diners, splashing can further be prevented when soup and water are added, the barrier-free soup-adding hot pot hasthe characteristics of convenience in cleaning, simplicity and attractiveness, convenience in isolation of a seasoning from food materials, stirring and clamping are facilitated, food is convenient to find, lampblack is small, degree of automation is high, the hot pot is convenient to use, and the like, and the barrier-free soup-adding hot pot is easy to popularize and use.

The invention belongs to the technical field of food processing and discloses stable food-grade low-fat lard-based oil-in-water emulsion and the preparation thereof. The stable food-grade low-fat lard-based oil-in-water emulsion is prepared from lard, lard-based monoglyceride, lard-based diacylglycerol, sodium caseinate and distilled water, wherein the mass ratio of the lard to the lard-based monoglyceride to the lard-based diacylglycerol to the sodium caseinate to the distilled water is 5:(0.5-2):(3-4.5):1:89. The lard-based emulsion fat ball particles are small, the emulsion liquid drops are distributed uniformly, the average particle size of the fat balls maintains about 0.2 to 7.0 microns when the fat balls are placed within 24 hours, and the system has high stability; in the prepared lard-based emulsion, the lard content is 5 percent, the total fat content is 10 percent and the fat content is low; when the lard-based emulsion is applied in the field of food, the lard-based emulsion contributes to avoidance that eaters take excessive fat, and is good for health.

The invention relates to an external application Chinese medicine composition for treating hemorrhoids. The external application Chinese medicine composition comprises the following raw materials by weight: 21-30g of sodium sulfate, 5-12g of myrrh, 11-15g of alum, 11-20g of borax and 0.5-1g of borneol. The using method is that: the raw materials are ground, are evenly mixed, are packaged in two bags and are put into a small plastic bag for closed preservation, and totally fourteen bags are prepared; one bag per time is put into a basin and is mixed with 1000ml of boiling water, fumigation is conducted first and washing is conducted thereafter for 10-30 minutes, and two times per day are required; for patients with erosion around anuses or severe hemorrhoids, moisture burn ointment is coated on the edge of the anuses after fumigation and washing, one suppository for treating hemorrhoids is inserted into the anus, and one treatment course comprises six days; after the patients use the medicine, the symptom at the anus is relieved or disappeared in 3-5 days, and the using method can be changed to one time of fumigation and washing after the symptom is relieved or disappeared to continuously consolidate the treatment for one treatment course. The medicine is used to treat 960 cases of patients with hemorrhoids in five years, the safety is proved to be high, no relapse occurs, the clinical cure rate is about 58 percent and the total effective rate is about 95 percent.