43results about How to "Avoid ingestion" patented technology

The invention relates to the field of specific molecular identification and diagnosis reagent and in particular discloses a near infrared fluorescent dye with structural formulas I and II; and the invention also discloses a near infrared molecular probe which is obtained through covalent bonding between the near infrared fluorescent dye with the structural formulas I and II and a ligand of specific molecules. The near infrared molecular probe can be used for early diagnosis of turmour diseases.

The invention belongs to the field of biotechnology, and relates to a slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system, and a preparation method thereof. The slightly acidic environment targeted polypeptide modified tumor targeted nano drug delivery system is prepared via self-assembly of a slightly acidic environment targeted polypeptide modified dendrimer encapsulated gene, wherein the surface of the dendrimer is rich of amino groups. According to the preparation method, a polypeptide of transmembrane helix protein C derived from bacteria visual purple is used for modifying a high molecular carrier, enrichment and adhesion onto cells is realized via a pH sensitive cell membrane insertion method, and entering into cells is realized via electrostatic adsorption guided endocytosis, so that untaking of tumor cells on drugs is improved, and toxic and side effects are reduced. According to the tumor targeted nano drug delivery system, cell membrane is taken as the target point, and the polypeptide is taken as the target head group in tumor slightly acidic environment, targeting and curing efficiency are high, the preparation method is simple and convenient, and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.

The invention belongs to the technical field of medicine, and designs and synthesizes a series of disulfide bond-containing micromolecular prodrugs in which carbon chains in different lengths are linked (sulfur atoms in the disulfide bond are respectively located alpha, beta and gamma sites of an ester bond). PTX (Paclitaxel)-CIT (Citronellol) is used as a sample, and a synthesis method is simpleand easy. On the basis, a micromolecular prodrug self-assembly nano-drug delivery system is prepared. The preparation method is simple and convenient, the stability is high, and efficient encapsulation and delivery of drugs are realized. The invention discovers that the disulfide bond has redox dual sensitivity, can be fractured under the action of high-expression ROS (Reactive Oxygen Species) andGSH (Glutathione) of tumor cells, and PTX can be released; particularly, redox dual hypersensitivity is shown by PTX-CIT prodrugs (alpha-PTX-SS-CIT), which are located in the alpha site of a carbonylgroup, of the disulfide bond, the alpha-PTX-SS-CIT prodrugs can be quickly fractured to release the PTX and take effects, an anti-tumor effect of the PTX is remarkably improved, and a wide development prospect is obtained.

Compositions containing ketone bodies and / or metabolic precursors thereof suitable for administration to humans and animals, which are characterized by (i) enhancing cardiac performance, especially the efficiency of the heart in utilizing glucose, (ii) providing energy, especially is to provide energy in diabetes and insulin resistance, (iii) to treat conditions caused by brain cell damage, especially by delaying or preventing brain damage in memory-related areas of the brain, such as in Alzheimer's disease and Brain damage found in brains with similar conditions. These compositions can be used as nutritional supplements, for example for athletes, or for the treatment of diseases, especially disorders related to cardiac insufficiency, insulin resistance and neuronal damage. The invention also provides methods of treatment as well as novel esters and polymers for inclusion in the compositions of the invention.

A gas turbine combustion system has a combustion system wall delimiting a flow path for hot and pressurized combustion gas and at least one resonator with a resonator volume. The resonator volume is delimited by resonator walls, where one of the resonator walls is located adjacent to or is formed by the combustion system wall. The resonator has at least one cooling fluid supply opening which is open towards a cooling fluid source. It further has a neck opening which is open towards the flow path and which is implemented in the form of a neck slot.

The invention belongs to the technical field of medicines and relates to a photosensitizer-hypoxia activated prodrug integrated prodrug. According to the invention, a photosensitizer and a hypoxia activated prodrug are connected through a bond which breaks under triggering by photo-induced electron transfer, a bond sensitive to active oxygen, or a bond which breaks under the triggering by photo-induced electron transfer and is sensitive or non-sensitive to active oxygen, so the photosensitizer and the hypoxia activated prodrug can be efficiently co-loaded and synchronously delivered. Pyropheophorbide a is used as a photosensitizer, PR104A is used as a hypoxia activated prodrug, a thioketal bond or monothioether bond or non-sensitive carbonate bond is employed for connecting pyropheophorbide with PR104A to synthesize an integrated prodrug, and then a self-assembled nanometer drug delivery system is prepared. According to the invention, a preparation process is simple; the drug loading capacity of the nanoparticles is high; the particle size of the nanoparticles is small and uniform, so the nanoparticles can be enriched at a tumor part through an EPR effect; while photodynamic therapy is conducted, the selective release of the hypoxia activated prodrug in the tumor is triggered through dual modes of PET and ROS; and the photodynamic therapy promotes the activation of the hypoxiaactivated prodrug, and significantly improves the synergistic anti-tumor effect of the photosensitizer and the hypoxia activated prodrug.

The invention relates to the technical field of polymer materials, and particularly relates to preparation and application of a mixed structure PLGA-PLL-PEG (Polylactide Acid Glycolic Acid-Polylysine-Polyethylene Glycol) targeting polymer carrier. The preparation is characterized in that polylactide acid glycolic acid and side chain protected polylysine are acted by a dehydrating agent and then connected in the block way to form a midbody; the midbody is deprotected and then connected with activated polyethylene glycol in the grafting manner, so that the polylactide acid glycolic acid-polylysine-polyethylene glycol polymer having the molecular weight of 4*10 <4> to the power of 4 to 5*10<5> is obtained. The polymer is used for carrying various medicines and also capable of being coupled with various ligands to realize targeted medicine delivery. The preparation of the polymer carrier provided by the invention is few in synthesis steps, mild in reaction conditions, available in materials and convenient for product purification.

The invention discloses medicine carrying polymer micelle which is methyl polyethylene glycol polylactic acid segmented copolymer micelle carried with hydrophobicity drugs; the grain size is 50-100nm, and the dispersion coefficient PI of the grains is more than or equal to 0.05 and is less than or equal to 0.09; the invention further discloses a preparation method of the medicine carrying polymer micelle; the grain size of the medicine carrying polymer micelle is small, the grain size distribution range is centralized, the stability is good, and the in vitro releasing experiment and the in vitro macrophagocyte cytophagy experiment can reach good effect. The preparation method of the medicine carrying polymer micelle has the following characteristics: the operation is simple and convenient; the encapsulating rate is high, and the highest encapsulating rate can be up to more than 90%; in addition, the prepared medicine carrying polymer micelle has good performance.

The present invention relates to lipoid microspere injection composition containing liposoluble toad cake extract and its preparation process. The injection composition contains liposoluble toad cake extract 0.0001-5 wt%, liposoluble medium 1-30 wt%, surfactant 0.5-10 wt%, isoosmotic regulator 0.5-10 wt%, and water for the rest. The injection has anticancer and analgetic effects, less blood vessel irritation caused by toad cake, no toxicity on heart and capacity of raising the medicine concentration inside tumor.

The invention discloses a feed additive for reducing the cholesterol content in eggs and a preparation method thereof. Cholesterol has an important physiological function in animal body, is an important component of various mode structures of cells and nerve myelin sheath, and is a precursor for synthesizing bile, steroid hormone and vitamin D3; however, excessively high cholesterol concentration in blood causes high blood fat and a series of consequent cardiovascular diseases such as atherosclerosis, high blood pressure, coronary heart disease and the like. The feed additive disclosed by the invention comprises the following components in parts by weight: 16.35-18.25 parts of curcumin, 0.02-0.03 part of brochantite, 12.36-15.85 parts of hawthorn, 22.35-25.68 parts of safflower seed oil and 42.00-46.00 parts of natural red yeast rice. The feed additive disclosed by the invention is used for reducing the cholesterol content in eggs.

The invention provides a barrier-free soup-adding hot pot, and relates to an intelligent hot pot. The intelligent hot pot comprises a table body, a heating device, a pot body, a rotating mechanism, anautomatic oil tank system, an automatic soup system, a lifting mechanism, an upper cover body and the like, wherein the table body comprises a table panel and a bottom plate; the center of the tablepanel is hollowed-out; the heating device is mounted at the hollowed-out position; the pot body is placed on the heating device; the heating device and the pot body are annular; the automatic oil tanksystem and the automatic soup system are mounted on the bottom plate; and the output end of the automatic oil tank system successively penetrates through the hollowed-out position of the table panel,the central hole of the heating device and the pot wall of the inner side of the pot body and extends to the position above a cavity of the pot body. Soup and edible oil can be added automatically, the space of the table body does not need to be occupied, the hot pot does not hinders diners, splashing can further be prevented when soup and water are added, the barrier-free soup-adding hot pot hasthe characteristics of convenience in cleaning, simplicity and attractiveness, convenience in isolation of a seasoning from food materials, stirring and clamping are facilitated, food is convenient to find, lampblack is small, degree of automation is high, the hot pot is convenient to use, and the like, and the barrier-free soup-adding hot pot is easy to popularize and use.

An airfoil cooling system (54) for a gas turbine engine (10) is disclosed. The airfoil cooling system (54) may be formed from at least a first cooling fluid supply system (56), and a second cooling fluid supply system (58). The first cooling fluid supply system (56) may be configured to supply cooling fluids at a first pressure to one or more airfoils of a first row (68) of airfoils, and the second cooling fluid supply system (58) may be configured to supply cooling fluids at a second pressure to the one or more airfoils of the first row (68) of airfoils. Additionally, the second pressure may be lower than the first pressure. As such, each of the one or more airfoils may be cooled by cooling fluids at two different pressures. In particular embodiments, this may allow the airfoils to be cooled, while lowering the cost to the turbine engine (10) for providing such cooling.

The invention belongs to the technical field of food processing and discloses stable food-grade low-fat lard-based oil-in-water emulsion and the preparation thereof. The stable food-grade low-fat lard-based oil-in-water emulsion is prepared from lard, lard-based monoglyceride, lard-based diacylglycerol, sodium caseinate and distilled water, wherein the mass ratio of the lard to the lard-based monoglyceride to the lard-based diacylglycerol to the sodium caseinate to the distilled water is 5:(0.5-2):(3-4.5):1:89. The lard-based emulsion fat ball particles are small, the emulsion liquid drops are distributed uniformly, the average particle size of the fat balls maintains about 0.2 to 7.0 microns when the fat balls are placed within 24 hours, and the system has high stability; in the prepared lard-based emulsion, the lard content is 5 percent, the total fat content is 10 percent and the fat content is low; when the lard-based emulsion is applied in the field of food, the lard-based emulsion contributes to avoidance that eaters take excessive fat, and is good for health.

A process for producing a fat in which a triglyceride formed by the bonding of molecules of one highly unsaturated fatty acid respectively to the three hydroxy groups of glycerol accounts for 20 wt.% or more of all triglycerides, characterized by incubating a microorganism capable of yielding the fat and collecting the fat according to need; and a fat obtained by the process.

The invention discloses a method for making baked food from emulsified lard oil, belongs to the field of food, and provides a formula and a making method of the emulsified lard oil and a making method applied to baked food. The emulsified lard oil is mainly composed of lard oil, soybean lecithin, molecular distillation monoglyceride and concentrated whey protein. The baked food made from the emulsified lard oil is natural in raw material, safe, reliable and beneficial to body health; during baked food production, no deep-dry process exists, the content of the lard oil in the made baked food is lower than 20%, the fat content is low, a user can be prevented from taking in excessive fat, and the baked food is good for human health.

The invention discloses a preparation method of a green degradable rice hull fast food oil absorption film. The preparation method comprises the following steps: carrying out cleaning, acid treatmentand steam explosion on rice hulls; preparing a colloidal solution containing chitosan, polylactic acid, isopropyl titanate triisostearate, and the like; compounding the rice husks and the colloidal solution to prepare a film; carrying out phase inversion on the prepared film; and performing lipophilic treatment on the prepared thin film. The preparation method of the oil absorption film provided by the invention is simple and easy to operate; the raw materials are cheap, easy to obtain, safe, non-toxic and low in cost, the prepared fast food oil absorption film has the advantages of being safe, environmentally friendly, attractive, degradable and the like, excessive oily substances overflowing from upper-layer food can be effectively adsorbed when the fast food oil absorption film is placed at the bottom of a fast food box, and the fast food oil absorption film is particularly suitable for staple food fast food mixed with cooked rice such as cooked rice.

The invention belongs to the technical field of medicines, relates to a photosensitizer-chemotherapeutic drug 'photosensitizer-chemotherapeutic integration' micromolecule prodrug, and aims to connecta chemotherapeutic drug with a photosensitizer through ester bonds or mono-thioether bonds to achieve efficient co-carrying and synchronous delivery of the chemotherapeutic drug and the photosensitizer. The photosensitizer-chemotherapeutic drug is prepared from paclitaxel as a chemotherapeutic drug and coked phaeophytin a as a photosensitizer, a self-assembled nano medicine delivery system is alsoprepared, and synergetic medicine release, in-vivo pharmacokinetics and anti-tumor effects of the drug are evaluated. The predrug is simple in preparation process, small and uniform in nanoparticle size, beneficial to enrichment of nanoparticles at tumor parts through an EPR (Enhanced Permeability and Retention) effect, super large in drug loading capacity and easy in surface modification, and reticuloendothelial system uptaking can be effectively avoided, in addition, uptaking of tumor cells upon the nanoparticles can be effectively improved; while photodynamic treatment is carried out, selective release of medicines can be synergistically triggered in tumor cells; by adopting the 'photosensitizer-chemotherapeutic integration' micromolecule prodrug self-assembled nano drug delivery system designed by the invention, the synergetic anti-tumor effects of the photosensitizer and the chemotherapeutic drug can be remarkably improved.

The invention designs and synthesizes a series of paclitaxel-oleic acid small-molecular prodrugs; with the application of a chemical connecting arm which is sensitive to an oxidation-deoxidation environment, the rapid release of the drugs in tumor cells is promoted. On the basis, small-molecular prodrug self-assembled nano-drug delivery systems are prepared. The small-molecular prodrug self-assembled nano-drug delivery systems have the advantages that by virtue of a one-step nano-precipitation method, nano-drug self-assembled nanoparticles are simple in preparation process and easy for industrialization; the nano-drug self-assembled nanoparticles are small and uniform in grain size (to 100nm), and the nano-drug self-assembled nanoparticles are enriched in a tumor part by virtue of an EPR (enhanced permeability and retention) effect; an ultrahigh drug-loading capacity is guaranteed, which is beneficial for reducing adverse reactions caused by auxiliary materials and biological materials; surface modification is easy to implement, and the intake of a reticuloendothelial system can be effectively avoided and the intake of the tumor cells to the nanoparticles can be improved by virtue of PEG (polyethylene glycol) and active targeting modification; and on the basis of the sensitivity of the chemical connecting arm to the oxidation-deoxidation microenvironment of the tumor cells, the specific drug release of paclitaxel in the tumor part is achieved, a curative effect is improved and toxic and side effects are reduced.

The invention relates to a cabazitaxel weakly-alkaline derivative and a preparation thereof, in particular to synthesis of the cabazitaxel weakly-alkaline derivative, a liposome preparation containingthe cabazitaxel weakly-alkaline derivative and application of the cabazitaxel weakly-alkaline derivative in a drug delivery system, and belongs to the technical field of medicines. According to the cabazitaxel weakly-alkaline derivative, cabazitaxel is connected with a weakly-alkaline intermediate through an ester bond, the ester bond can be broken under the action of esterase in vivo, and an active drug is released. The structural general formula is shown in the specification, wherein a connecting group is C1-C4 alkyl, C3-C6 naphthenic base or phenyl; [N] is an N-methyl piperazinyl group, apiperidinyl group, a 4-(1-piperidinyl) piperidinyl group, a morpholinyl group, a pyrrolidine group or other tertiary amine structures. The cabazitaxel weakly-alkaline derivative disclosed by the invention can be prepared into the liposome preparation. The liposome preparation has the characteristics of high drug loading capacity, high encapsulation efficiency, good stability and the like. After injection administration, the in-vivo circulation time of the drug can be greatly prolonged, the accumulation amount of the drug at a tumor part is increased, and the anti-tumor effect and the tolerancedose are improved. .

The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and / or treatment of induced cell toxicity, such as nephewrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment, the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of docking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.

The invention relates to an external application Chinese medicine composition for treating hemorrhoids. The external application Chinese medicine composition comprises the following raw materials by weight: 21-30g of sodium sulfate, 5-12g of myrrh, 11-15g of alum, 11-20g of borax and 0.5-1g of borneol. The using method is that: the raw materials are ground, are evenly mixed, are packaged in two bags and are put into a small plastic bag for closed preservation, and totally fourteen bags are prepared; one bag per time is put into a basin and is mixed with 1000ml of boiling water, fumigation is conducted first and washing is conducted thereafter for 10-30 minutes, and two times per day are required; for patients with erosion around anuses or severe hemorrhoids, moisture burn ointment is coated on the edge of the anuses after fumigation and washing, one suppository for treating hemorrhoids is inserted into the anus, and one treatment course comprises six days; after the patients use the medicine, the symptom at the anus is relieved or disappeared in 3-5 days, and the using method can be changed to one time of fumigation and washing after the symptom is relieved or disappeared to continuously consolidate the treatment for one treatment course. The medicine is used to treat 960 cases of patients with hemorrhoids in five years, the safety is proved to be high, no relapse occurs, the clinical cure rate is about 58 percent and the total effective rate is about 95 percent.

The invention belongs to the technical field of anti-tumor nano-carriers, and discloses a nano-carrier system for tumor in-situ assembly, a drug loading system and application. The tumor in-situ assembled nano drug delivery system disclosed by the invention is composed of nano particles prepared from a polyethylene glycol-polylactic acid material with a specific structure, so that long circulation of the nano particles in blood can be realized; when the nano-particles reach a weak acid environment of tumors, the nano-particles can be assembled into large-size particle aggregates in situ in the tumors, enrichment and retention of a nano drug carrying system and carried drugs in the tumors can be enhanced, and the nano-particles serve as an extracellular'drug warehouse 'to slowly release the carried drugs to reach extracellular target spots, so that the anti-tumor curative effect is achieved; and a new thought is provided for developing a delivery carrier system of extracellular / membrane target antitumor drugs.

The present invention relates to weakly basic derivatives of cabazitaxel and preparations thereof, in particular to the synthesis of weakly basic derivatives of cabazitaxel, liposome preparations containing the derivatives and their application in drug delivery systems, belonging to medical technology field. The weakly basic derivative of cabazitaxel is connected with a weakly basic intermediate through an ester bond, and the ester bond can be broken by the action of esterase in the body to release the active drug. Its structural general formula is as follows: wherein, linking group is C 1 -C 4 Alkyl, C 3 -C 6 Cycloalkyl or phenyl; [N] is N-methylpiperazinyl, piperidinyl, 4-(1-piperidinyl) piperidinyl, morpholinyl, tetrahydropyrrolyl or other tertiary amine structures. The weakly basic derivatives of cabazitaxel of the present invention can be prepared into liposome preparations. The liposome preparation has the characteristics of high drug loading, high encapsulation efficiency, good stability and the like. After injection, it can greatly increase the circulation time of the drug in the body, increase the accumulation of the drug in the tumor site, and improve the anti-tumor effect and tolerance dose. .

The invention discloses a preparation method of a green degradable rice hull fast food oil absorption film. The preparation method comprises the following steps: carrying out cleaning, acid treatmentand steam explosion on rice hulls; preparing a colloidal solution containing chitosan, polylactic acid, isopropyl titanate triisostearate, and the like; compounding the rice husks and the colloidal solution to prepare a film; carrying out phase inversion on the prepared film; and performing lipophilic treatment on the prepared thin film. The preparation method of the oil absorption film provided by the invention is simple and easy to operate; the raw materials are cheap, easy to obtain, safe, non-toxic and low in cost, the prepared fast food oil absorption film has the advantages of being safe, environmentally friendly, attractive, degradable and the like, excessive oily substances overflowing from upper-layer food can be effectively adsorbed when the fast food oil absorption film is placed at the bottom of a fast food box, and the fast food oil absorption film is particularly suitable for staple food fast food mixed with cooked rice such as cooked rice.

The invention belongs to the field of biotechnology, and relates to a tumor active targeting nano drug delivery system controlled by slightly acidic environment, and a preparation method thereof. The tumor active targeting nano drug delivery system controlled by slightly acidic environment is prepared by self-assembly of a targeting peptide modified dendrimer encapsulated gene, wherein connection of the targeting peptide is realized via pH sensitive bonds using shielding molecules, and the surface of the dendrimer is rich of amino groups. According to the nano drug delivery system, because modification effect of the shielding molecules in the system, the active targeting nano drug delivery system is improved; targeting and curing efficiency are high; the preparation method is simple and convenient; and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.