A kind of tumor active targeting nano-drug delivery system and preparation method thereof controlled by slightly acidic environment

An active targeting, slightly acidic environment technology, applied in antitumor drugs, pharmaceutical formulations, drug combinations, etc., to achieve the effects of improving targeting efficiency, simple preparation method, high targeting and treatment efficiency
CN103705464BInactive Publication Date: 2015-10-07FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2015-10-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biotechnology, and relates to a tumor active targeting nano drug delivery system controlled by slightly acidic environment, and a preparation method thereof. The tumor active targeting nano drug delivery system controlled by slightly acidic environment is prepared by self-assembly of a targeting peptide modified dendrimer encapsulated gene, wherein connection of the targeting peptide is realized via pH sensitive bonds using shielding molecules, and the surface of the dendrimer is rich of amino groups. According to the nano drug delivery system, because modification effect of the shielding molecules in the system, the active targeting nano drug delivery system is improved; targeting and curing efficiency are high; the preparation method is simple and convenient; and tumor cell drugs, which are derived from human or animal, and is used for targeted therapy, can be prepared.
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Description

technical field

[0001] The invention belongs to the field of biotechnology and relates to a drug delivery system, in particular to a tumor active targeting nanometer drug delivery system and a preparation method thereof which is controlled and activated by a slightly acidic environment. Background technique

[0002] In recent years, tumor-targeted drug delivery systems have become a research hotspot in the field of anti-tumor drug delivery. There are mainly two strategies for the construction of targeted drug delivery systems: passive targeting and active targeting; the passive targeting is mainly based on the EPR effect of tumor tissue on macromolecules, while the active targeting is based on the specific binding of macromolecules. The ligands of the receptors are overexpressed on the surface of tumor cells, the drug delivery system is modified, and the specific binding properties are transferred to the drug delivery system to achieve targeted delivery. Ligand-modified nan...

Claims

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