3results about How to "Improve targeting efficiency" patented technology

This invention relates to novel, highly efficient subcellular targeted drug delivery conjugates, their preparation methods, compositions, and uses. The conjugates include a carrier module, a controlled-release module, a connecting arm, a subcellular targeting module, and a pharmacodynamic module. The conjugates of this invention can be used in applications such as highly efficient photodynamic therapy, chemotherapy, and immunotherapy targeting organelles, or in combination thereof.

The application discloses a ROS response type selenium-cerium composite nanometer enzyme and a preparation and application thereof, and comprises the following steps: S1, preparation of an organic silicon source double-[3-(triethoxy)silyl propyl] diselenide silane; S2, preparation of a mesoporous organic silicon nanometer material bridged by a diselenide bond; S3, preparation of a hyaluronic acid coated cerium dioxide nanometer enzyme; and S4, preparation of the ROS response type selenium-cerium composite nanometer enzyme. Through the three core innovations of embedding a diselenide bond skeleton, preloading HA-CeO2 in a channel and multi-enzyme simulation cooperation, the application systematically solves the key bottlenecks of stability, functionality, targeting and antioxidant efficiency of the existing nanometer platform, and provides a high-efficiency, safe and intelligent drug-free nanometer treatment new strategy for acute kidney injury.

The application relates to a composition for liver cancer imaging and treatment, relates to the field of tumor detection, realizes efficient and accurate cancer tissue identification by identifying specific markers on the surface of tumor cells or tissues, and further finds a highly potential liver cancer marker.