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Nano-carrier entrapping anticancer drugs and gold nanoparticles lipids and preparation method of nano-carrier

A lipid nanocarrier and gold nanoparticle technology, applied in the field of medicine, can solve problems such as monotherapy, and achieve the effect of overcoming poor specificity, improving efficiency and good stability

Inactive Publication Date: 2015-11-25
河南省医药科学研究院
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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of tumor monotherapy, and to provide a method for constructing lipid nanocarriers based on targeting tumor cells and co-loading anticancer drugs and thermotherapeutic agents. The lipid nanocarriers can play a role in tumor targeting chemotherapy Combining or synergistically treating tumors with hyperthermia can reduce the toxic and side effects of anticancer drugs and improve the antitumor effect

Method used

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  • Nano-carrier entrapping anticancer drugs and gold nanoparticles lipids and preparation method of nano-carrier
  • Nano-carrier entrapping anticancer drugs and gold nanoparticles lipids and preparation method of nano-carrier
  • Nano-carrier entrapping anticancer drugs and gold nanoparticles lipids and preparation method of nano-carrier

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Embodiment Construction

[0024] Cholesterol, soybean phospholipids, hydrogenated phospholipids, anticancer drugs, DSPE-PEG(2000)-Mal were ultrasonically dissolved in chloroform, chloroform was removed by rotary evaporation under reduced pressure, and a transparent film was formed in a round bottom flask, and 4ml of gold nanorod aqueous solution was added , continue to rotate for hydration, and then ultrasonically dissolve after hydration is complete. Probe in an ice bath in an ultrasonic cell pulverizer for more than 40 times, centrifuge it at 8000r / min for 10min, discard the precipitate, and then add an aqueous solution of functional molecules to it , vortexed for 1 min, and shaken at room temperature for 12 h to obtain lipid nanocarriers loaded with anticancer drugs and gold nanoparticles. The specific examples are as follows, but not limited thereto.

[0025] Lipid Nanocarriers Encapsulating Anticancer Drugs and Gold Nanoparticles Anti-cancer drugs functional molecule AuNRs / TaxLNC...

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Abstract

The invention relates to a nano-carrier entrapping anticancer drugs and gold nanoparticles lipids and a preparation method of the nano-carrier, and belongs to the technical field of medicines. The nano-carrier entraps the anticancer drugs and the gold nanoparticles jointly and then is modified by functional molecules and (or) high molecular polymers. Draw ratio of gold nanoparticles in the carrier is 1:1-8:1, average grain diameters are 1 nanometer to 100 nanometers, and the temperature can rise to 25-80 DEG C after solution of the nano-carrier is irradiated by near-infrared light. The average grain diameter of the lipid nano-carrier is 20 nanometers to 500 nanometers. The lipid nano-carrier has effects of tumor targeted chemical treatment and / or tumor thermal synergy therapy, toxic and side effects of the anticancer drugs can be reduced, and an anti-tumor effect is improved. A preparation technology is simple, and the stability of the lipid nano-carrier is high.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a lipid nanocarrier jointly loaded with anticancer drugs and gold nanoparticles and a preparation method thereof. Background technique [0002] Due to its unique optical and physical and chemical properties, the application of gold nanorods in tumor hyperthermia has become a hot spot of scientific research. With the change of the aspect ratio of gold nanorods, it can be adjusted from the visible light region to the near-infrared region, and the wavelength range of the near-infrared region is the transmission window of body tissues. Killing tumor cells provides a theoretical basis. Under the irradiation of laser, gold nanorods can absorb near-infrared low-energy radiation, and make electronic transitions inside them to form unstable electron-hole pairs. When the rearrangement of electron-hole pairs returns to a stable state, a large number of hot. The h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K47/42A61K47/22A61K47/34A61K38/17A61P35/00A61K31/337A61K31/704A61K31/7048A61K31/4745
Inventor 华海婴赵永星张楠梁倩刘丹李沙沙赵阳李峰宋丽莉
Owner 河南省医药科学研究院
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