A kind of antineoplastic drug or drug carrier comprising cyclodextrin modified by glutamine

An anti-tumor drug, glutamine technology, applied in the field of anti-tumor drugs, can solve the problems of large batch-to-batch variation, difficulty in evaluating the safety of nano-carriers, limiting nano-carriers, etc., and achieve the effect of avoiding toxicity
CN110124057BActive Publication Date: 2022-04-19GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
Publication Date
2022-04-19

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Abstract

The present invention relates to an antitumor drug or a drug carrier comprising a glutamine-modified cyclodextrin, and its application in the preparation of an antitumor drug, wherein the glutamine-modified β-cyclodextrin can form an inclusion complex with a chemotherapeutic drug Drugs that transport chemotherapy drugs into tumor cells by targeting the abnormally high-expressed glutamine transporter ASCT2 in tumors, glutamine-modified cyclodextrin or glutamine-modified β-cyclodextrin combined with doxorubicin or paclitaxel The formed clathrate can target the glutamine transporter ASCT2, and be recognized by the transporter, transported into the tumor cells, and then kill the tumor cells; in the tumor-bearing body, the tumor is the largest glutamine uptake organ, while the liver, Kidneys, lungs, and muscles are all glutamine-secreting organs, so targeting glutamine transporters can reduce the toxic and side effects of chemotherapy drugs on liver, kidney, lungs and other major organs.
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Description

technical field

[0001] The invention belongs to the field of antitumor drugs, in particular to an antitumor drug containing glutamine-modified cyclodextrin. Background technique

[0002] Cancer is a major problem that threatens public health. Despite the emergence of new technologies such as immunotherapy and anti-angiogenic agents in recent years, chemotherapy based on cytotoxic drugs remains the cornerstone of cancer treatment. However, the side effects of chemotherapy on normal organs are still the main factor limiting its clinical efficacy. Glutamine is the most abundant amino acid in the cytoplasm, and it participates in biological processes such as energy production, biomacromolecule synthesis, and redox in cells. Reliance on exogenous glutamine is a common feature of most tumor cell metabolism. Therefore, most tumor cells highly express glutamine transporter ASCT2, such as lung cancer, breast cancer, colorectal cancer, etc., and the expression of ASCT2 is closely r...

Claims

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