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Lipoid microsphere injection containing toad cake extract and its preparing method

A technology of lipid microspheres and injection, applied in the field of medicine, can solve problems such as hidden dangers and inappropriateness of the clinical safe use of toadstool

Inactive Publication Date: 2007-06-27
SHENYANG YAODA MEDICINE DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is not appropriate to use 5-hydroxytryptamine as the quality control component of the drug, but it will also bring potential hidden dangers to the safe clinical use of Chansu

Method used

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  • Lipoid microsphere injection containing toad cake extract and its preparing method
  • Lipoid microsphere injection containing toad cake extract and its preparing method
  • Lipoid microsphere injection containing toad cake extract and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation process of the prescription of Chansu lipid microsphere injection

[0054] Prescription 1:

[0055] Coix Seed Oil 1-30g

[0056] Toad Fat Soluble 0.0001g-5g

[0057] Lecithin 0.5-10g

[0058] Glycerin 0.5-10g

[0059] Add water for injection to 100ml

[0060] Preparation method 1:

[0061] (1) Add the prescribed amount of lecithin and glycerin to an appropriate amount of water for injection and mix at 40-100°C to obtain the water phase; (2) Add the bufo fat soluble matter to coix seed oil, and heat at 40-100°C until the active ingredient After completely dissolving, pass through 0.45 μm to obtain a clear oil phase; (3) Mix the water phase and oil phase and transfer to a tissue grinder, stir for a few minutes, 1-5 times, to prepare colostrum; (4) Take the above-mentioned colostrum Add water for injection to the full amount of the milk, adjust the pH to 5-8, transfer it to a high-pressure homogenizer, homogenize it for 1-10 times, and take a sample for m...

Embodiment 2

[0134] Study on the Extraction Technology of Toad Paste

[0135] 1 The influence of different concentrations of ethanol on the extraction results

[0136] Select the fine powder of toad venom, use 10 times the amount (1g:10mL) of different ratios of ethanol to heat and reflux for 1 hour, let it cool to room temperature, filter with suction, evaporate the filtrate to dryness, and vacuum dry the dried filtrate and residue for one day. Measure the contents of the index components in the dry matter respectively. The results are shown in Figure 2.

[0137] With the increase of the ethanol concentration, the content of the index components in the dry extract increases. It can be seen from the appearance that the color of the 90% ethanol extract is close to colorless, while the 70% ethanol extract is yellow. Simultaneously also because 90% ethanol has strong impurity removal ability, the quality of dry extract is obviously lower than that of lower concentration ethanol to extract d...

Embodiment 3

[0148] Determination of Particle Size and ζ-Potential of Chansu Lipid Microsphere Injection

[0149] Particle size and particle size distribution are one of the most important characteristics of lipid microspheres. At present, there is no unified regulation on the particle size requirements of lipid microspheres for intravenous injection. The reported products generally have uniform particle sizes, with an average of less than 1 μm, and no aggregation. Phenomenon, in 1 drop of emulsion (0.05mL), there are no more than 2 emulsion droplets of 10-15μm, and no emulsion droplets larger than 15μm. At present, the commonly used methods for the determination of emulsion droplet size of lipid microspheres include microscopy, dynamic light scattering, laser scattering, and Coulter counting. The particle size measurement method of LM in this test is to use optical microscope and photon correlation spectroscopy (Photon-Correlation Spectroscopy, PCS), also known as the principle of dynamic...

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Abstract

The present invention relates to lipoid microspere injection composition containing liposoluble toad cake extract and its preparation process. The injection composition contains liposoluble toad cake extract 0.0001-5 wt%, liposoluble medium 1-30 wt%, surfactant 0.5-10 wt%, isoosmotic regulator 0.5-10 wt%, and water for the rest. The injection has anticancer and analgetic effects, less blood vessel irritation caused by toad cake, no toxicity on heart and capacity of raising the medicine concentration inside tumor.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a lipid microsphere injection (oil-in-water emulsion) containing venom fat-soluble matter and a preparation method thereof. Background technique [0002] Over the years, although people have made many efforts and made great progress, the harm of tumors has not been effectively curbed so far. Statistics show that in 2002, the number of deaths from malignant tumors and cancers in China accounted for 25.37% of the total number of deaths in that year, and tumors have become the number one killer that endangers human health. In the past two years, the incidence of tumors has shown an upward trend, and the age of onset has also dropped significantly from the average age of 55. It can be predicted that in the next 20 to 30 years, the morbidity and mortality of cancer will continue to rise. [0003] Cancer pain is the most common and difficult symptom of cancer patients, and it is als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/127A61K9/107A61P35/00A61K35/65
Inventor 唐星王涛吴谢军
Owner SHENYANG YAODA MEDICINE DEV
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