Pharmaceutical composition containing ganciclovir compound, and preparation method thereof

A technology of ganciclovir and its composition, which is applied in the field of antiviral drug preparations, can solve the problems of reduced dissolution rate of ganciclovir and failure to meet the requirements of ganciclovir injection, etc.
CN102210686AInactive Publication Date: 2011-10-12罗诚
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
罗诚
Publication Date
2011-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a pharmaceutical composition containing a ganciclovir compound, and a preparation method thereof. The pharmaceutical composition is composed of ganciclovir, polysorbate 80, sodium hydroxide and dextran. The ganciclovir pharmaceutical composition overcomes the irritation of the existing ganciclovir lyophilized powder injections on an injection site, and improves the stability of the ganciclovir lyophilized powder injection and the compliance of patients.
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Description

technical field

[0001] The invention relates to a preparation of antiviral drugs, in particular to a pharmaceutical composition containing a ganciclovir compound and a preparation method thereof. Background technique

[0002] Ganciclovir (ganciclovir), as shown in formula I, has a chemical name of 9-(1,3-dihydroxy-2-propoxymethyl)guanine.

[0003]

[0004] Formula I

[0005] This product is white crystalline powder with molecular formula C 9 h 13 N 5 0 4 , with a molecular weight of 255.23, slightly soluble in water (the solubility in water at 25°C is 2.6mg / mL), almost insoluble in methanol, insoluble in dichloromethane; slightly soluble in hydrochloric acid solution or sodium hydroxide solution. The solubility of its monosodium salt in water at 25°C is 50 mg / mL. At physiological pH, ganciclovir sodium salt exists in a non-ionic form with a solubility of 6 mg / mL.

[0006] Ganciclovir is an antiviral drug commonly used in clinical practice. It has broad-spectrum anti...

Claims

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