Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pinocembrin and cyclodextrin or cyclodextrin derivative clathrate compound

A technology of cyclodextrin and pinazin, which is applied in the field of medicine, can solve the problems that pinecone is insoluble in water, difficult to take orally or inject, poor oral absorption, etc., and achieves clinical application, good safety, and good dissolution Effect

Inactive Publication Date: 2012-10-10
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the technical problems that pinoquinone is insoluble in water, has poor oral absorption, and is difficult to be administered orally or injected in the prior art, the present invention provides the following technical solutions:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pinocembrin and cyclodextrin or cyclodextrin derivative clathrate compound
  • Pinocembrin and cyclodextrin or cyclodextrin derivative clathrate compound
  • Pinocembrin and cyclodextrin or cyclodextrin derivative clathrate compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Preparation of liquid pinenin hydroxypropyl-β-cyclodextrin inclusion compound solution

[0042] (1) Weigh 40g of hydroxypropyl-β-cyclodextrin, pour it into 400ml of distilled water, stir to dissolve;

[0043] (2) Separately weigh 1g of Pinustin, add 20ml of absolute ethanol to dissolve it, and pour the solution into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0044] (3) Stir the mixed solution at 40-50°C for 20 minutes by magnetic stirring method, observe the solution until it is clear and transparent, and obtain the clathrate solution of hydroxypropyl-β-cyclodextrin derivatives of pininetin.

Embodiment 2

[0045] Example 2: Preparation of solid pinenin hydroxypropyl-β-cyclodextrin inclusion compound

[0046] (1), (2), (3) are the same as embodiment 1.

[0047] (4) Freeze-drying the clathrate solution of hydroxypropyl-β-cyclodextrin derivatives of pininetin to obtain solid clathrates of hydroxypropyl-beta-cyclodextrin derivatives of pinacetin.

Embodiment 3

[0048] Embodiment 3: Preparation of solid pinenin hydroxypropyl-β-cyclodextrin inclusion compound

[0049] (1) Weigh 20g of hydroxypropyl-β-cyclodextrin, put it into a mortar, add 100ml of distilled water, and grind to make a paste;

[0050] (2) Separately weigh 3g of pinocin, add 20ml of absolute ethanol to dissolve, and pour the solution into the above-mentioned hydroxypropyl-β-cyclodextrin solution;

[0051] (3) Grind the mixed liquid for 2 hours to obtain a uniform paste, filter it, and evaporate to dryness under reduced pressure to obtain a solid clathrate of pinosin cyclodextrin derivative.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pinocembrin and cyclodextrin or cyclodextrin derivative clathrate compound. Cyclodextrin or cyclodextrin derivatives are used for realizing the clathration on pinocembrin, the clathrate compound comprises the pinocembrin and cyclodextrin or cyclodextrin derivatives according to a mol ratio being 1:(1-100). The water solubility of the pinocembrin is improved, the treatment effect of the pinocembrin is more perfectly realized, the clathrate compound is suitable for being used for preparing solid preparations and liquid preparations required in clinics, and the preparations include transfusion, water injection, powder injection, oral liquid, syrup, tablets, capsules, granules and dispersible tablets. The clathrate compound can be used for preparing medicine for preventing and / or treating cardiovascular and cerebrovascular diseases, particularly cerebral apoplexy, and can also be used for preparing medicine for preventing and / or treating germ and / or fungal infection.

Description

[0001] This patent application is a divisional application, the application number of the original application is 200810084682.3, the application date is March 18, 2008, and the title of the invention is: "Pinenin Cyclodextrin or Cyclodextrin Derivative Inclusion Compound" technical field [0002] The present invention relates to clathrates of pinustin cyclodextrin or cyclodextrin derivatives, a preparation method thereof, pharmaceutical compositions containing such clathrates of pinustin cyclodextrins or cyclodextrin derivatives and in the preparation of medicines the use of. It belongs to the field of medical technology. Background technique [0003] Pinocembrin, also known as pinocembrin, pinocin, chemical name 5,7-dihydroxyflavanone (5,7-Dihydroxyflavanone), 2,3-dihydro-5,7-dihydroxy-2- Phenyl-4H-1-benzopyran-4-one (2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one), is a water-insoluble Dihydroflavonoids, the structure is as follows: [0004] [0005] There...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/10A61K9/19A61K9/16A61K9/20A61K9/48A61K31/353A61K47/40A61P31/04A61P31/10A61P9/10
Inventor 吴松杜冠华戚燕高梅杨庆云光红梅李薇王月华童元峰
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com