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Use of penoniflorin in preparing medicine for preventing and treating depression and medicine composition thereof

A composition and a technology of paeoniflorin, which are applied in the field of new medical uses of paeoniflorin and pharmaceutical compositions thereof, can solve problems such as unclear mechanism of action, and achieve the effects of low price, less toxic and side effects, and lasting effects

Inactive Publication Date: 2009-03-18
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recent studies have found that paeoniflorin also has neuroprotective effects, but its mechanism of action is still unclear

Method used

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  • Use of penoniflorin in preparing medicine for preventing and treating depression and medicine composition thereof
  • Use of penoniflorin in preparing medicine for preventing and treating depression and medicine composition thereof
  • Use of penoniflorin in preparing medicine for preventing and treating depression and medicine composition thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The present invention is a natural active substance paeoniflorin extracted and separated from the roots of the paeoniaceae plants Paeonia lactiflora and tree peony, which can be used in drugs for treating depression.

[0026] 1. Separation and purification of the active ingredient paeoniflorin

[0027] Using chemical methods to prepare paeoniflorin from the roots of peony and tree peony as raw materials, the process of preparing paeoniflorin is as follows:

[0028] The roots of peony or peony are crushed, extracted with 70% ethanol under reflux, and concentrated under reduced pressure to obtain a dry extract. The extract is fully dissolved in water and passed through a macroporous adsorption resin column, eluted with water and 20% ethanol, and collected 20 % Ethanol eluent, concentrated under reduced pressure to obtain extract, and separated by silica gel column chromatography to obtain paeoniflorin monomer compound. (Jiang Huanrong, Pei Xuhong, Hu Haiwei, Exploration of Se...

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PUM

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Abstract

The invention relates to an application of paeoniflorin in drugs for preventing and treating depression and a pharmaceutical composition thereof, and the pharmaceutical composition contains effective dose of the paeoniflorin and a pharmaceutical acceptable carrier. The pharmaceutical composition can be prepared into various conventional liquid formulations or solid formulations. The paeoniflorin is proved to have better efficacy for the depression and long duration of the efficacy through a rat forced swimming test, a open field test and a new environment feeding inhibition test. The drugs which take the paeoniflorin as an active ingredient and are used for treating and preventing the depression have good effects, long duration, insignificant toxicity and side effect and low price.

Description

Technical field [0001] The invention relates to a new medical use of paeoniflorin and its pharmaceutical composition. Background technique [0002] Depression seriously endangers human life and health. Depression (Depression) refers to a type of mood disorder syndrome characterized by low mood, slow thinking, and psychomotor retardation symptoms such as decreased interest and decreased initiative. The incidence rate is very high, about 15-17%, and in recent years it has been increasing year by year; according to the World Health Organization, depression will become the first cause of disability by 2020 and will be the main killer of humans in the 21st century (Murray , 1997). [0003] Paeoniflorin is a single-layer glycoside compound, and its molecular formula is shown in Formula I. It is a natural active substance derived from the root of Paeonia albiflora Pall, a plant of the Ranunculaceae family, the root of P.suffrsticosa Andr, and the root of P.delarayi Franch. The content i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/24
Inventor 朱心红严华成孙丽荣高天明曲宏达袁春华李树基李晓文方莹莹
Owner SOUTHERN MEDICAL UNIVERSITY
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