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Water-Soluble Aspirin Composition

Compositions in which aspirin is present in combination with alkaline compounds, especially those containing water of crystallization (hydrates), deteriorate on standing. This deterioration may take several forms: It can be a physical deterioration in which such aspirin compositions become completely unmanageable, wet, gummy, sticky masses; or chemical decomposition in which aspirin loses its molecular structure chiefly by losing the acetyl group. The latter is accompanied by formation of acetic acid, the mixture developing its characteristic acetic odor. In both cases, such compositions become entirely unsuitable for all practical commercial and medicinal purposes. Yet, when preparation of water-soluble aspirin compositions is desired, it is impossible to avoid the use of alkaline compounds. This is because the only known method of converting aspirin into soluble form is by means of reacting it with an alkaline compound to form the soluble salt of aspirin. Unexpectedly, it was discovered and is the substance of the present invention that there are two compounds both of which are alkaline and contain water of crystallization (hydrates), and which, in combination with aspirin, give soluble compositions of outstanding stability. Unexpectedly, it was discovered and is also the substance of the present invention that there are several sugar substitutes which have demonstrated an acceleration of absorption into the bloodstream and have demonstrated a reduction in acididity which in turn should reduce or eliminate the potential for bleeding in the stomach. These two compounds are sodium citrate (tri) dihydrate, and potassium citrate (tri) monohydrate. Artificial sweeteners can also be combined in the soluble aspirin composition.
Owner:MILNE DON
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