Pinocembrin and cyclodextrin or cyclodextrin derivative inclusion compound
A technology of cyclodextrin and pinacol, applied in the field of medicine, can solve the problems of difficulty in oral administration or injection, insolubility in water, poor oral absorption, etc., and achieves the advantages of clinical application, good safety and good dissolution. Effect
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Embodiment 1
[0041] Embodiment 1: Preparation of liquid pinenin hydroxypropyl-β-cyclodextrin inclusion compound solution
[0042] (1) Weigh 40g of hydroxypropyl-β-cyclodextrin, pour it into 400ml of distilled water, and stir to dissolve;
[0043] (2) Another 1 g of pinocin was weighed, dissolved in 20 ml of absolute ethanol, and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;
[0044] (3) The mixed solution was stirred at 40-50° C. for 20 minutes by magnetic stirring method, and the solution was observed until it was clear and transparent, and the clathrate solution of pinenin hydroxypropyl-β-cyclodextrin derivative was obtained.
Embodiment 2
[0045] Example 2: Preparation of solid pinenin hydroxypropyl-β-cyclodextrin inclusion compound
[0046] (1), (2), (3) are the same as embodiment 1.
[0047] (4) Freeze-drying the clathrate solution of the pinacetin hydroxypropyl-β-cyclodextrin derivative to obtain a solid pinacetin hydroxypropyl-beta-cyclodextrin inclusion complex.
Embodiment 3
[0048] Embodiment 3: Preparation of solid pinenin hydroxypropyl-β-cyclodextrin inclusion compound
[0049] (1) Weigh 20g of hydroxypropyl-β-cyclodextrin, put it into a mortar, add 100ml of distilled water, and grind to make a paste;
[0050] (2) Another 3 g of pinocin was weighed, dissolved in 20 ml of absolute ethanol, and the solution was poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;
[0051] (3) Grinding the mixed liquid for 2 hours to obtain a uniform paste, filtering, and evaporating to dryness under reduced pressure to obtain a solid clathrate of pinasin cyclodextrin derivatives.
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