In situ gel preparation loaded with Kangfuxin and its preparation method and use
An in-situ gel and preparation technology, which is applied to medical preparations of non-active ingredients, medical raw materials derived from arthropods, drug combinations, etc., can solve problems such as easy loss, wound infection, and short duration of drug effect, and achieve The effect of avoiding contamination of the wound, accurate dosage, and prolonging the residence time
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Embodiment 1
[0022] Preparation of rehabilitation new in situ gel
[0023]
[0024] Take (18wt%) poloxamer 407 and (2wt%) poloxamer 188 in the prescribed amount, add an appropriate amount of water for injection, stir and heat at 60°C to fully swell, and then place it in a 4°C environment until a clear and transparent solution is formed; The Kangfuxin dry powder and 0.1wt% of methyl p-hydroxybenzoate in prescription quantity (5wt%) are dissolved in water for injection, then slowly add above-mentioned solution under ice-bath and stirring condition, stir evenly, adjust pH value with sodium hydroxide or hydrochloric acid To 4.0 ~ 8.0, can be divided into packages.
Embodiment 2
[0026] Preparation of rehabilitation new in situ gel
[0027]
[0028] Get (20wt%) poloxamer 407 of prescription quantity, (2wt%) HPMC, add appropriate amount of water for injection, 60 ℃ of stirring and heating are fully swelled, and then place 4 ℃ of environment afterward, until forming clear and transparent solution; Then prescription quantity (5wt%) %) of Kangfuxin dry powder and methyl p-hydroxybenzoate (0.1wt%) are dissolved in water for injection, then slowly add the above-mentioned solution under ice bath and stirring conditions, stir well, adjust the pH value to 4.0 with sodium hydroxide or hydrochloric acid ~8.0, ready to pack.
Embodiment 3
[0030] Preparation of rehabilitation new in situ gel
[0031]
[0032] Get the (18wt%) polyethylene glycol of prescription quantity 4000 - Polylactic acid 1000 , (2wt%) HPMC, add appropriate amount of water for injection, stir and heat at 60°C to fully swell, and then place it in a 4°C environment until a clear and transparent solution is formed; (0.1wt%) dissolved in water for injection, then slowly add the above solution under the conditions of ice bath and stirring, stir evenly, adjust the pH value to 4.0-8.0 with sodium hydroxide or hydrochloric acid, and divide the package to obtain the product.
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