In situ gel preparation loaded with Kangfuxin and its preparation method and use

An in-situ gel and preparation technology, which is applied to medical preparations of non-active ingredients, medical raw materials derived from arthropods, drug combinations, etc., can solve problems such as easy loss, wound infection, and short duration of drug effect, and achieve The effect of avoiding contamination of the wound, accurate dosage, and prolonging the residence time

Inactive Publication Date: 2012-11-21
王成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of its liquid preparation is that it is easy to lose, the duration of drug effect is short, it needs to be applied many times, it is inconvenient to use, and it is easy to cause wound infection.
[0004] The development of modern science has promoted the continuous progress of the Chinese medicine industry, but it still has not got rid of its low-tech status. To realize the modernization of Chinese medicine and improve its competitiveness, it is necessary to adopt modern science and technology, apply new technology, new equipment, and new auxiliary materials. , to research and develop new dosage forms of traditional Chinese medicine, and to prepare new preparations with high technical content and good curative effect is the fundamental way to fundamentally change the backwardness of the field of traditional Chinese medicine preparations and improve the pharmaceutical technology of traditional Chinese medicine as a whole.
[0005] Those skilled in the art have been working hard to improve the shortcomings of the existing preparations of Kangfuxin and improve the drug action time in order to better exert the curative effect. The content is low, the effect and advantages are not obvious, the application of ordinary gel is inconvenient, and the dosage is relatively large, especially for patients with large area injuries, it cannot be guaranteed to apply evenly, so there is no good solution so far

Method used

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  • In situ gel preparation loaded with Kangfuxin and its preparation method and use
  • In situ gel preparation loaded with Kangfuxin and its preparation method and use
  • In situ gel preparation loaded with Kangfuxin and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of rehabilitation new in situ gel

[0023]

[0024] Take (18wt%) poloxamer 407 and (2wt%) poloxamer 188 in the prescribed amount, add an appropriate amount of water for injection, stir and heat at 60°C to fully swell, and then place it in a 4°C environment until a clear and transparent solution is formed; The Kangfuxin dry powder and 0.1wt% of methyl p-hydroxybenzoate in prescription quantity (5wt%) are dissolved in water for injection, then slowly add above-mentioned solution under ice-bath and stirring condition, stir evenly, adjust pH value with sodium hydroxide or hydrochloric acid To 4.0 ~ 8.0, can be divided into packages.

Embodiment 2

[0026] Preparation of rehabilitation new in situ gel

[0027]

[0028] Get (20wt%) poloxamer 407 of prescription quantity, (2wt%) HPMC, add appropriate amount of water for injection, 60 ℃ of stirring and heating are fully swelled, and then place 4 ℃ of environment afterward, until forming clear and transparent solution; Then prescription quantity (5wt%) %) of Kangfuxin dry powder and methyl p-hydroxybenzoate (0.1wt%) are dissolved in water for injection, then slowly add the above-mentioned solution under ice bath and stirring conditions, stir well, adjust the pH value to 4.0 with sodium hydroxide or hydrochloric acid ~8.0, ready to pack.

Embodiment 3

[0030] Preparation of rehabilitation new in situ gel

[0031]

[0032] Get the (18wt%) polyethylene glycol of prescription quantity 4000 - Polylactic acid 1000 , (2wt%) HPMC, add appropriate amount of water for injection, stir and heat at 60°C to fully swell, and then place it in a 4°C environment until a clear and transparent solution is formed; (0.1wt%) dissolved in water for injection, then slowly add the above solution under the conditions of ice bath and stirring, stir evenly, adjust the pH value to 4.0-8.0 with sodium hydroxide or hydrochloric acid, and divide the package to obtain the product.

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Abstract

The invention belongs to the field of medicinal preparations and a novel medical technology and relates to an in situ gel preparation loaded with Kangfuxin and its preparation method and use. The in situ gel preparation loaded with Kangfuxin has temperature sensibility. The in situ gel preparation loaded with Kangfuxin is characterized in that Kangfuxin as a raw material and polymers are dissolved in a buffer solution or purified water according to a ratio. Because of polymer reverse-phase gel properties, the in situ gel preparation loaded with Kangfuxin is in a liquid state and can freely flow at a room temperature (of 20 DEG C) under storage conditions, and when the in situ gel preparation loaded with Kangfuxin is spread on a wound, under the action of a body temperature, the in situ gel preparation loaded with Kangfuxin forms fast semi-solid gel. The in situ gel preparation loaded with Kangfuxin is convenient for patient use, improves patient compliance, can effectively store drugs and can slowly release drugs so that drug action time is prolonged and drug efficacy is improved. Through oral administration, the in situ gel preparation loaded with Kangfuxin can be used for treating blood stasis, stomachache, gastrorrhagia, gastric ulcer and duodenal ulcer and assistantly treating Yin deficiency and pulmonary tuberculosis, and phthisis. Through external administration, the in situ gel preparation loaded with Kangfuxin can be used for treatment and anti-adhesion of metal-inflicted wounds, trauma wounds, ulcer wounds, fistula wounds, burn wounds, scald wounds, bedsore wounds and surgical wounds.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and new pharmaceutical technologies, and relates to a temperature-sensitive rehabilitation in-situ gel, its preparation method and application. It is made of Kangfuxin as raw material, which is dissolved in buffer solution or purified water in proportion to the polymer material. Using the property of polymer material reverse gel, the Kangfuxin in-situ gel can be stabilized at room temperature (20°C) and It is a free-flowing liquid under storage conditions and rapidly forms a semi-solid gel at body temperature. Background technique [0002] In situ gel (in situ gel), that is, in situ gel, is a kind of preparation that can undergo a phase transition immediately at the site of administration after administration in a solution state, and form a non-chemically cross-linked semi-solid gel from a liquid state. The gel has good tissue compatibility, can stay in the administration site for a lon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/00A61K47/38A61K47/36A61K47/34A61K47/32A61P17/02
Inventor 王成
Owner 王成
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