507results about How to "Increase incidence" patented technology

The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and methods for using the animals to identify agents that are effective to deplete cells bearing human CD20. The transgenic animals are also useful to test safety and efficacy of anti-CD20 therapies.

The subject invention pertains to materials and methods for the prevention and treatment of gastrointestinal diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Therapeutic compositions of the invention include compositions that can neutralize hydrogen peroxide, such as reducing agents and oxidizing agents. In one embodiment, a therapeutic composition of the invention comprises a reducing agent such as sodium thiosulfate. Therapeutic compositions of the invention can optionally include compounds with antibacterial activity, compositions that inhibit bacterial adherence to cells and tissue, compositions that inhibits epithelial lipid peroxidation, compositions that add viscosity to a solution, compositions that inhibit most cells, and/or compositions that help to seal or repair tight junctions between cells of the colonic epithelium of the gastrointestinal tract. Methods of the invention include administration of compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient.

A solar cell includes: an photoelectric conversion body including a first main surface and a second main surface opposed to the first main surface; a first electrode provided on the first main surface; a second electrode provided on the second main surface; a first conductive connection member connected with the first electrode for connecting the solar cell and another solar cell, wherein the first conductive connection member includes a conductive soft layer at an area facing the first electrode, and the first electrode includes a conductive soft layer at an area facing the first conductive connection member; and a first resin adhesive bonding the first conductive connection member to the first electrode in such a manner that the conductive soft layer of the first electrode and the conductive soft layer of the first conductive connection member abut on each other.

A system and method for an improved multiple hard-disk-drive data-storage enclosure. Some embodiments position drives in counter-rotating pairs, each simultaneously accessing half the data, such that seek-caused actuator rotational-acceleration vibration cause simultaneous canceling rotational torque. Some embodiments position the edge of a first drive (or drive pair) at an angle to the actuator midpoint of a nearby second drive (or drive pair), such that rotational-acceleration vibration from a seek-caused actuator rotation in the first drive does not cause a rotational movement into the second drive that affects the tracking or seek operation. Some further embodiments position drives in a herringbone pattern to redirect air flow in addition to reducing rotational-acceleration vibration interaction. Other embodiments include a printed wire circuit board mounted to reduce the rotational-acceleration vibration interaction.

The invention provides a method for precisely editing a genome DNA sequence. A TALEN, CRISPR/Cas9 and other gene targeting technologies and homologous recombination technologies are utilized in a combined mode for precisely editing the genome DNA sequence. According to the method, the technical problem that in the prior art, a specific sequence cannot be deleted is solved, the specific base sequence can be seamlessly inserted or deleted in a fixed point mode, and seamless free modification of the genome DNA sequence of eukaryocyte is achieved for the first time.

The invention relates to a sandwich structure wave-absorbing composite material and a preparation method thereof, an integrated sandwich structure comprises an intermediate layer, an upper skin and alower skin, the intermediate layer is a honeycomb material filled with carbon nanotube/cellulose wave-absorbing foam, the upper skin is a quartz fiber cloth reinforced resin material having electromagnetic wave transmission characteristics, and the lower skin is a carbon fiber cloth-reinforced resin material having electromagnetic wave reflection characteristics. Specifically, the preparation method is carried out according to the following steps: 1. the intermediate layer, namely the honeycomb material filled with the carbon nanotube/cellulose wave-absorbing foam is prepared by a freeze-drying method; 2. the upper kin and the lower skin are prepared by impregnating resin with quartz fiber cloth/carbon fiber cloth; and 3. the intermediate wave-absorbing layer is compounded with the upper kin and the lower skin. The sandwich structure wave-absorbing composite material prepared by the method can replace existing wave-absorbing materials, and is widely used in aircrafts, ground weapon equipment, surface ships and other parts that have stealth requirements for electromagnetic waves.

Tissue optical clearing devices for subsurface photodisruption and methods of use generally comprise an energy source in conjunction with mechanical optical clearing for the creation of high precision surface and subsurface photodisruption and/or photoablation.

A positive electrode according to an embodiment includes a positive electrode current collector, a positive electrode mixture layer disposed on the current collector, and an intermediate layer disposed between the positive electrode current collector and the positive electrode mixture layer. The intermediate layer includes particles, the particles are mainly composed of a material having a thermal conductivity of 100 W/m·K or more and a specific resistance of 10³ Ω·m or more, and the particles have a Vickers hardness of 5 GPa or more.

The present invention provides a high-strength steel sheet useful for applications to automobile steel sheets and the like and having excellent deep drawability, a tensile strength (TS) of as high as 440 MPa or more, and a high r value (average r value≧1.2), and a process for producing the steel sheet. The steel sheet has a composition containing, by % by mass, 0.010 to 0.050% of C, 1.0% or less of Si, 1.0 to 3.0% of Mn, 0.005 to 0.1% of P, 0.01% or less of S, 0.005 to 0.5% of Al, 0.01% or less of N, and 0.01 to 0.3% of Nb, the Nb and C contents in steel satisfying the relation, (Nb/93)/(C/12)=0.2 to 0.7, and the balance substantially including Fe and inevitable impurities. The steel microstructure contains a ferrite phase and a martensite phase at area ratios of 50% or more and 1% or more, respectively, and the average r value is 1.2 or more.

A solid-state imaging device includes an imaging unit, a charge control unit, and a horizontal transfer unit. The imaging unit includes a plurality of pixels arranged into a matrix for performing photoelectric conversion, and a plurality of vertical transfer units arranged in columns for vertically transferring signal charges of the plurality of pixels on a column-by-column basis. In a predetermined operation mode, a predetermined number of columns greater than one are used as a unit, and the charge control unit stops transferring charges from a vertical transfer unit in a predetermined column of the predetermined number of columns, and adds the signal charges transferred from the vertical transfer units in the two or more remaining columns of the predetermined number of columns to output the added signal charges. The horizontal transfer unit horizontally transfers the signal charges output from the charge control unit.

The present invention relates to a light source-guide structure having an LED as a light source and a backlight apparatus having the same. The light source-guide structure includes a light guide plate with grooves formed in a peripheral side thereof and a light source having a transparent package fitted into the groove of the light guide plate with an LED chip inside the transparent package. The structure also includes a wiring substrate for seating the LED chip and reflecting the light from the LED chip to the light guide plate and a reflection layer attached on upper surfaces of the light source and the light guide plate. With the light source inserted into the light guide plate, the loss of light is minimized while the horizontal beam angle of light from the LED is increased, minimizing the peripheral area.

The invention discloses a terrestrial flower water culture domestication method, which comprises the following steps of (1) plant selection: selecting plants with good growth condition and no pest disease; (2) root washing and pot releasing: cleanly washing plant root system by clean water, removing adherent clay or substrates, and shearing rotten roots or damaged roots; (3) root system sterilization: soaking the roots into KMnO4 (potassium permanganate) solution to be subjected to sterilization treatment after the root systems are trimmed; (4) rooting agent treatment: adopting prepared rooting agent solution for carrying out root soaking treatment; (5) plant fixation: fixing the plant roots and stems by clay particles, then, placing the plants into a fixed planting cup, and placing the fixed planting cup into a water culture container; (6) water culture management: firstly, using clean water for water culture for 6 to 8 days, and then adopting nutrition solution for culture. The method provided by the invention aims at the problem that the terrestrial plants are difficult to domesticate, a set of cleaning, sterilization and root soaking treatment process is created, the later stage overall nutrition solution recipe is adopted, and the water culture root generation rate of the water culture flowers is as high as 99 percent.

An injection-foaming molding process for manufacturing a formed article by injecting a molten resin containing a foaming agent into a cavity of a mold being retained in an openable state and then expanding the cavity by opening the mold to allow the resin to foam includes: i) a step of discontinuing a cavity of a mold from a resin-reserving section located at front end of a screw immediately after the completion of injection of a molten resin containing an expandable resin into the mold cavity; and ii) a step of keeping the resin-reserving section under pressure at least equal to back pressure for charging during a period from the completion of injection to start of charging the molten resin containing the expandable resin for next shot, decreasing pressure in the resin-reserving section to back pressure for charging, and then starting the charging. According to the process, a molding cycle can be shortened and a lightweight formed article by foaming having high rigidity and good appearance can be obtained.

A hybridization detecting unit which includes a reaction region in which hybridization takes place, a plurality of sites (e.g., the surface of electrodes) arranged in the reaction region to which is fixed a nucleic acid for detection, and means for sequentially moving by dielectrophoresis the target nucleic acid introduced into the reaction region according to the order of arrangement of the sites to which is fixed a nucleic acid for detection. A sensor chip provided with the hybridization detecting unit. The detecting unit compulsorily moves the target nucleic acid into the region where a probe nucleic acid for detection exists, thereby increasing the probability of hybridization taking place.

A disk launching apparatus that employs a handle connected to a flexible shaft that is connected to a launching head. The head includes a first arcuate portion and a second arcuate portion arranged in a semi-circular configuration to define a space in which a disk is retained in contact with the first and second arcuate members. At least one securing point is located on the first arcuate member and a plurality of securing points located on the second arcuate member. An elastic band is attached between the first securing point on the first arcuate member and one of the plurality of securing points located on the second arcuate member, thereby crossing a disk held within the launching head.

A method and apparatus for enhanced THz radiation coupling to molecules, includes the steps of depositing a test material near the discontinuity edges of a slotted member, and enhancing the THz radiation by transmitting THz radiation through the slots. The molecules of the test material are illuminated by the enhanced THz radiation that has been transmitted through the slots, thereby producing an increased coupling of EM radiation in the THz spectral range to said material. The molecules can be bio-molecules, explosive materials, or species of organisms. The slotted member can be a semiconductor film, a metallic film, in particular InSb, or layers thereof. THz detectors sense near field THz radiation that has been transmitted through said slots and the test material.

An air conditioner for vehicles in which the probability of executing pre-air conditioning is increased so that it may be prevented that the inside of the vehicle cannot be often in a comfortable state before the driver gets into the vehicle. The air conditioner performs air conditioning of a vehicle having a traveling motor and an engine as drive sources and comprises a pre-air conditioning main switch. The crew permits operation of pre-air conditioning by turning the switch on. When the pre-air conditioning main switch is set on, an engine control section performs charge preference control where battery charge takes precedence of engine fuel consumption and performs normal control where engine fuel consumption takes precedence when the pre-air conditioning main switch is set off.

The invention provides a method for rapidly culturing shoot tips in vitro, which is characterized in that in the first step, selecting stolon of the strawberries sprouted at the same year, washing to be clean and disinfecting; in the second step, cutting 0.1-0.5 mm shoot tips of the disinfected and cleaned strawberries stolon under the anatomical lens, inoculating to a culture medium for germination culture, cutting the new sprouts after the 0.5-1.5 cm new sprouts are grown on the shoot tips, inoculating to an enrichment medium for inducing clustered shoots; in the third step, cutting the cluster buds to simple buds, inoculating to a rooting medium for rooting culture; transferring test tube plantlets to a substrate formed by mixing perlite and peat, watering and covering a plastic film for insulation and moisture retention, revealing the plastic film for gradually hardening, transferring the seedling to a plastic potted tray filled with pure peat, watering and covering the plastic film for insulation and moisture retention, and directly planting the seedling to a field. The invention has the advantages of high reproductive rate, rapid reproduction speed and high survival rate.

Disclosed is a preparation method for a coated silicon/carbon/graphite composite negative electrode material. The preparation method comprises the steps of adding silicon powder and a dispersing agent into deionized water, wherein the D50 of the silicon powder is 1.2-1.5[mu]m; performing ball milling for 2-10h, and screening 100-mesh slurry; adding graphite, an organic carbon source and a binder into the deionized water, stirring and mixing uniformly, and enabling the obtained mixture to be mixed with the slurry, and continuously to stir the mixture uniformly; performing spray drying to obtain a silicon/carbon/graphite precursor; performing thermolysis on the silicon/carbon/graphite precursor under the protection of nitrogen or argon; and after screening, mixing the precursor with a coating agent, and performing ball milling for 1-3h, and carrying out heat treatment at a temperature of 400-600 DEG C under the protection of nitrogen or argon for 2-6h to obtain the coated silicon/carbon/graphite composite negative electrode material. According to the preparation method for the coated silicon/carbon/graphite composite negative electrode material provided by the invention, the initial charge-discharge efficiency of the material can be improved.

Atrial arrhythmias, a major contributor to cardiovascular morbidity, are believed to be influenced by autonomic nervous system tone. The main purpose of this invention was to highlight new findings that have emerged in the study of effects of autonomic nervous system tone on atrial arrhythmias, and its interaction with class III antiarrhythmic drug effects. This invention evaluates the significance of sympathetic and parasympathetic activation by determining the effects of autonomic nervous system using a vagal and stellar ganglions stimulation, and by using autonomic nervous system neurotransmitters infusion (norepinephrine, acetylcholine). This invention evaluates the autonomic nervous system effects on the atrial effective refractory period duration and dispersion, atrial conduction velocity, atrial wavelength duration, excitable gap duration during a stable circuit (such atrial flutter circuit around an anatomical obstacle), and on the susceptibility of occurrence (initiation, maintenance and termination) of atrial re-entrant arrhythmias in canine. This invention also evaluates whether autonomic nervous system activation effects via a local neurotransimitters infusion into the right atria can alter those of class III antiarrhythmic drug, sotalol, during a sustained right atrial flutter. This invention represents an emergent need to set-up and develop a new class of anti-cholinergic drug therapy for the treatment of atrial arrhythmias and to combine this new anti-cholinergic class to antiarrhythmic drugs. Furthermore, this invention also highlights the importance of a local application of parasympathetic neurotransmitters/blockers and a catheter ablation of the area of right atrium with the highest density of parasympathetic fibers innervation. This may significantly reduce the occurrence of atrial arrhythmias and may preserve the antiarrhythmic effects of any drugs used for the treatment of atrial re-entrant arrhythmias.