Optogenetic control of reward-related behaviors

a reward-related behavior and optogenetic technology, applied in the field of optogenetic control of reward-related behaviors, can solve the problems of imposing costs on governments and societies, reducing the effectiveness of the treatment process, and reducing the effect of undesired effects on the reinforcement of other behaviors
US20170157269A1Inactive Publication Date: 2017-06-08THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Publication Date
2017-06-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are compositions and methods for disrupting at least one reward-related behavior in an individual through the use of light-responsive opsin proteins used to control the polarization state of the cholinergic intemeurons of the nucleus accumbens or the striatum.
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Description

CROSS REFERENCE TO RELATED APPLICATION

[0001] This application is a divisional of U.S. Ser. No. 13 / 882,670 filed, Aug. 12, 2013, which is a national stage filing under 35 U.S.C. 371 of PCT / US2011 / 059295, filed Nov. 4, 2011, which claims priority to U.S. Provisional Application No. 61 / 410,692 filed on Nov. 5, 2010, each of which applications is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0002] This application pertains to compositions comprising animal cells expressing light-responsive opsin proteins on their plasma membranes and methods of using the same to selectively hyperpolarize cholinergic interneurons residing in microcircuits of the nucleus accumbens or dorsal striatum to affect one or more behaviors associated with reward-related conditioning in the animal.BACKGROUND

[0003] Substance abuse and dependency are important problems facing societies all over the world. According to the World Drug Report 2008, about 5% of the world population uses illicit dru...

Claims

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