9 results about "High frequency stimulation" patented technology

The application provides a novel light-activated channel protein VR3.0 and uses thereof. The light-activated channel protein VR3.0 series provided in this application has a wide range of photosensitive wavelengths, higher sensitivity to light response, faster photoresponse kinetics, maintaining stable photocurrent signals under high-frequency stimulation while exhibiting good response amplitude and frequency under light stimulation of various wavelengths (especially white light, natural light). The light-activated channel protein VR3.0 series provided in this application has a clear therapeutic effect on retinal photoreceptor cell degenerative diseases, and can be used to prepare drugs for restoring the photoreceptor function of the retina, restoring the visual or photosensitive ability of subjects, and treating retinal degenerative diseases.

This invention discloses a closed-loop adaptive transcranial interferometric stimulation method and system based on tTIS and fNIRS. The method includes: acquiring and analyzing relevant information to obtain the target region, core stimulation parameters, and required stimulation duration; configuring one or more stimulation units; attaching the stimulation units to their corresponding positions and calibrating the electrode contact impedance; controlling the electrodes to apply high-frequency stimulation signals to the target region corresponding to each stimulation unit based on frequency, phase, and amplitude tri-control technology; acquiring and processing cerebral blood oxygenation information in real time to obtain information to be analyzed; comparing and analyzing the information to be analyzed and adjusting the core stimulation parameters; repeating the above steps, and terminating stimulation when the current stimulation duration exceeds the required stimulation duration. This invention achieves precise and adaptive transcranial interferometric stimulation by acquiring cerebral blood oxygenation in real time and adjusting stimulation parameters in a closed loop, ensuring the safety and effectiveness of brain neuromodulation.

The application provides a novel light-sensitive channel protein VR2.0 and uses thereof. The light-sensitive channel protein VR2.0 series provided in this application demonstrates profound therapeutic effects in the treatment of retinal photoreceptor cell degenerative diseases. This novel light-sensitive channel protein exhibits enhanced photosensitivity, fast kinetics, and reduced side effects. Under identical photostimulation conditions, VR2.0 demonstrates faster response frequencies while maintaining stable photocurrent signals even during high-frequency stimulation. This application provides a better optogenetic therapeutic option for retinal photoreceptor cell degenerative diseases, and has significant application and promotion value.

This invention discloses a system and method for treating patients with symptoms of restless legs syndrome (RLS) or periodic limb movement disorder (PLMD) using high-frequency stimulation by applying a high-frequency pulsed electrical stimulation therapeutic signal to the peroneal nerve or its branches, wherein the therapeutic signal is above the motor threshold of the muscles innervated by the peroneal nerve or its branches. Surface EMG (sEMG) responses to nerve stimulation can be used to assess a patient's response to nerve stimulation or to evaluate the efficacy of nerve stimulation, such as comparing various nerve stimulation parameter settings and selecting between these settings to achieve or balance one or more goals. The sEMG response can be obtained during muscle rest or during muscle activation.

Systems and methods for treating neurodegenerative disorders with high frequency stimulation are disclosed. A representative method for treating a patient includes applying an electrical signal to the patient via a treatment system that includes a signal delivery element positioned at or within a white matter of the patient's brain, spinal cord, or both, the electrical signal having a frequency of from about 1.5 kHz to about 100 kHz.

Waveforms for a stimulator device, and methods and circuitry for generating them, are disclosed having high- and low-frequency aspects. The waveforms comprise a sequence of pulses issued at a low frequency which each pulse comprising first and second charge-balanced phases. One or both of the phases comprises a plurality a monophasic sub-phase pulses issued at a high frequency in which the sub-phase pulses are separated by gaps. The current during the gaps in a phase can be zero, or can comprise a non-zero current of the same polarity as the sub-phase pulses issued during that phase. The disclosed waveforms provide benefits of high frequency stimulation such as the promotion of paresthesia free, sub-threshold stimulation, but without drawbacks inherent in using high-frequency biphasic pulses.

A system and method of use thereof for inducing colonic motility includes providing stimulations to a rectum of an individual. The stimulations include a plurality of low-frequency stimulations and a plurality high-frequency stimulations. The stimulations can be configured to activate sensory neurons and modulate the recto-colonic reflex pathway without directly activating motor neurons.

The present application belongs to the technical field of medical apparatus and instruments, and particularly relates to a meridian high-frequency stimulation instrument with power feedback, mainly comprising a PID controller, a driving module, a high-frequency oscillation module, a PVDF measurement film assembly, a signal conditioning module and the like. The desired treatment power is input into the therapeutic instrument, and the difference between the actual power and the desired treatment power is input into the PID controller. The controller outputs a duty cycle signal to the driving module, which drives the high-frequency oscillation module to work. The PVDF measurement assembly measures the output power of the oscillation module, and the actual power signal is reflected after calibration by the signal conditioning module, serving as a feedback signal to realize closed-loop control of the output power. The treatment process is more safe and controllable, and the skin is prevented from being excessively stimulated.

Systems and methods for treating a patient having symptoms of restless leg syndrome (RLS) or periodic limb movement disorder (PLMD) using high frequency stimulation by applying a high frequency pulsed electrical stimulation treatment signal to the peroneal nerve or a branch thereof, where the treatment signal is above the motor threshold of the muscles innervated by the peroneal nerve or branch. Surface EMG (sEMG) responses to the nerve stimulation can be used to assess the patient's response to the nerve stimulation, or to evaluate the efficacy of the nerve stimulation, such as comparing various nerve stimulation parameter settings and selecting between these settings to achieve or balance one or more objectives. The sEMG responses can be obtained with the muscle at rest or during muscle activation.