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16 results about "Molecular sensor" patented technology
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A molecular sensor or chemosensor is a molecular structure (organic or inorganic complexes) that is used for sensing of an analyte to produce a detectable change or a signal. The action of a chemosensor, relies on an interaction occurring at the molecular level, usually involves the continuous monitoring of the activity of a chemical species in a given matrix such as solution, air, blood, tissue, waste effluents, drinking water, etc. The application of chemosensors is referred to as chemosensing, which is a form of molecular recognition. All chemosensors are designed to contain a signalling moiety and a recognition moiety, that is connected either directly to each other or through a some kind of connector or a spacer. The signalling is often optically based electromagnetic radiation, giving rise to changes in either (or both) the ultraviolet and visible absorption or the emission properties of the sensors. Chemosensors may also be electrochemically based. Small molecule sensors are related to chemosensors. These are traditionally, however, considered as being structurally simple molecules and reflect the need to form chelating molecules for complexing ions in analytical chemistry. Chemosensors are synthetic analogues of biosensors, but such sensors incorporate biological receptor such as antibodies, aptamers or large biopolymers.
Graphene single-molecule sensing device based on pillararene as well as preparation method and application of graphene single-molecule sensing device
The invention relates to the technical field of single-molecule devices and sensors, in particular to a graphene single-molecule sensing device based on pillararene as well as a preparation method and application of the graphene single-molecule sensing device. The sensor comprises a pillararene molecule, the functional molecule is covalently connected between a graphene electrode pair through nucleophilic substitution reaction or amide condensation reaction under an alkaline condition, and the stability and the conductive reliability of a molecule-electrode interface are enhanced. According to the present invention, the column aromatic hydrocarbon molecules can selectively perform inclusion on the perfluorocarboxylic acid, and the combination of different types of perfluorocarboxylic acids and the column aromatic hydrocarbon molecules can show the difference characteristic of the conductive state so as to achieve the distinguishing of different perfluorocarboxylic acids, such that the method is hopeful to be used in the detection of perfluorocarboxylic acid. Meanwhile, perfluorocarboxylic acid can be effectively desorbed through methanol treatment, and an I-V signal is recovered to an initial state, so that the device has reusability. The preparation method provided by the invention is stable in process, high in repeatability and beneficial to large-scale production.
Owner:NANKAI UNIV
Molecular sensors and related methods
ActiveUS12607593B2Microbiological testing/measurementMaterial analysis by electric/magnetic meansGap junctionDNA
Electronic sensors configured to detect single molecules and DNA methods of using and manufacturing same are disclosed. A sensor may include source and drain electrodes spaced apart by a sensor gap; a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit; and a bridge molecule bridging across the sensor gap, connecting source and drain electrodes; and a probe coupled to the bridge molecule, wherein interaction of the probe with a nucleic acid is detectable by monitoring a parameter of the electrode circuit. In various examples, the nucleic acid comprises DNA or RNA.
Owner:SEMICONBIO INC
FRET biosensor and preparation method and application thereof
PendingCN121431454AFluorescence/phosphorescenceVector-based foreign material introductionSignal responseLiving cell
The invention discloses an FRET (Fluorescence Resonance Energy Transfer) biosensor as well as a preparation method and application thereof. The FRET biosensor is obtained by transfecting cells with plasmids for expressing a molecular sensor; the molecular sensor contains NEK7 protein, a fluorescence donor and / or a fluorescence receptor, and the fluorescence donor or the fluorescence receptor is connected to the N end or the C end of the NEK7 protein through a flexible chain. According to the invention, the FRET biosensor is designed, and multiple conditions are optimized, so that the signal response efficiency of the FRET biosensor is improved, and meanwhile, real-time monitoring of NLRP3 oligomerized living cells is realized, and screening of an NEK7-NLRP3 protein interaction interference inhibitor is realized.
Owner:CHINA PHARM UNIV
STM-BJ-based single-molecule sensor and application thereof
The invention discloses a single-molecule sensor based on STM-BJ and application of the single-molecule sensor, and belongs to the technical field of analytical chemistry. On the basis that 1, 3-bis (pyridine-4-yl) propane-diketone interacts with alcohols under the conditions of applying negative bias and applying a sodium sulfate aqueous solution to form a supramolecular junction, a supramolecular strategy is introduced into a gap between a probe and a sample table in STM-BJ, and specific single molecule detection of alcohol molecules is realized by using a negative bias working mode of STM. Compared with other traditional research means, the method provided by the invention not only can accurately identify alcohol molecules, has high sensitivity, but also can realize quantitative analysis of alcohols.
Owner:GUANGDONG UNIV OF TECH
High throughput stochastic bio-molecular sensor
ActiveUS12578328B2Component separationMaterial analysis by electric/magnetic meansSensor arrayBio molecules
What is described herein is a device for sensing a target, comprising a planar array of unique stochastic sensors, wherein each sensor is weakly cross-reactive with a unique determinant on the target; a means for capturing electrical signals from each sensor and the temporal duration of each signal; and a means for analyzing the cumulative signals from the array of stochastic sensors, and optionally further comprising a computer system for processing an algorithm for identifying the target based on the electrical signals from the sensors of the device.
Owner:MASSACHUSETTS INST OF TECH
Portable fluorescence sensor for rapidly and intelligently detecting sulfite content in food and preparation method of portable fluorescence sensor
PendingCN121783926AMaterial analysis by observing effect on chemical indicatorFluorescence/phosphorescenceBiotechnologyBisulfide
The invention discloses a portable fluorescence sensor for rapidly and intelligently detecting the content of sulfite in food and a preparation method thereof. The sensing chip has specific interaction with sulfite (bisulfite) through the molecular sensor LCMQ, changes of dual optical signals of color and fluorescence are generated, and the content of sulfite (bisulfite) in food is quantitatively detected through capture, recognition and analysis of a portable instant detection platform of a sensing chip-smart phone. The method has the characteristics of simplicity in preparation, low cost, high sensitivity, high selectivity, rapidness and readability, provides an intelligent and effective means for detection of sulfite (bisulfite) in food, provides powerful technical guarantee for self-monitoring and market supervision of food manufacturers, has great application prospects, and has great popularization significance.
Owner:GUANGXI UNIV
A base recognition method based on semiconductor SERS technology
The application discloses a base recognition method based on semiconductor SERS technology and belongs to the technical field of biomedical detection. The specific method comprises the following steps: step one, synthesis of TiO2 nanoparticles; step two, preparation of a TiO2 / 4-MBA system; and step three, base recognition detection. The TiO2 / MBA system can be used for accurate and rapid DNA base recognition, and the developed TiO2 / MBA system is simple to prepare and has excellent base test performance, and has a high market application prospect. The application not only provides a novel base detection method, but also has high sensitivity and selectivity, can recognize and detect four bases and the non-covalent interaction between the four bases and 4-MBA in two pH environments, and has a simple and rapid operation process. The application not only provides a new method for base analysis, but also provides technical support for early diagnosis of DNA related diseases, genomics research and development of molecular sensors, and has a wide application prospect.
Owner:NORTHEAST FORESTRY UNIV
Nanoporous membrane
A method of making a nanoporous membrane is constructed using an array of sacrificial nanopillars that print removable material on a substrate. After continuous deposition or even of covering layers with different properties, the sacrificial nanostructure is dissolved, and finally the nanoporous membrane with nanopores, channels and cavities designed with nanoscale sizes and geometrical shapes is formed. Thus, unprecedented unique functions are achieved in various technical fields (e.g., bioartificial organs, nanoelectronics, bioelectronics, molecular sensors and biomedical applications).
Owner:OSTIA TECHNOLOGY CO LTD
Membrane tension response type composite molecular sensor as well as preparation method and application thereof
PendingCN121406756AMicrobiological testing/measurementFluorescence/phosphorescenceMembrane tensionCholesterol
The invention discloses a membrane tension response type composite molecular sensor and a preparation method and application thereof, the membrane tension response type composite molecular sensor comprises a DNA tetrahedral framework formed by a plurality of single-stranded DNAs through complementary base pairing, and the single-stranded DNAs comprise single-stranded DNAs modified with vibration luminescent molecules, single-stranded DNAs modified with cholesterol molecules and unmodified single-stranded DNAs; the vibration luminescent molecule is loaded on the end point of one single-stranded DNA through covalent modification, and the cholesterol molecule is loaded on the end point of the other single-stranded DNA through covalent modification; the vibration light-emitting molecules are excited by single laser, switching between bending conformation and torsional conformation occurs, and then cell membrane tension is responded through emission wavelength intensity change. The membrane tension response type composite molecular sensor has the advantages of being controllable in size, high in brightness, high in cell membrane targeting performance and the like, fluorescence proportion imaging of cell membrane tension is achieved, and the huge potential of the membrane tension response type composite molecular sensor in research and application of the life process of stem cells is revealed.
Owner:SHANGHAI JIAOTONG UNIV
Electrochemical biomolecular sensor based on DNA molecular clock and construction method thereof
The application discloses a kind of electrochemical biomolecular sensor and construction method based on DNA molecular pendulum, including buffer solution, electrode, DNA double-stranded pendulum rod, the electrode, DNA double-stranded pendulum rod is set in buffer solution;Step voltage reduction signal molecule is inserted on the phosphate skeleton of the DNA double-stranded pendulum rod;One end of the DNA double-stranded pendulum rod is connected on electrode, and one single strand on the other end of the DNA double-stranded pendulum rod is connected with target aptamer.The application has wider detection range, higher sensitivity and lower detection limit, and has important significance for detecting protein, virus, nucleic acid and some small molecule substances.
Owner:NANJING FORESTRY UNIV
Nanoporous graphene membrane
A nanoporous graphene membrane fabrication method is formed using an array of sacrificial nanopillars of removable materials are printed onto a substrate, and subsequent growth of graphene. After serial deposition of overlayers of even dissimilar nature, the sacrificial nanostructures are dissolved, leaving nanoporous graphene membrane with nanopores, channels and cavities of nanoscale dimension and geometry designed and controlled, enabling untapped and unique functions in different technological areas such as filtration, electronics, and molecular sensors.
Owner:OSTIA TECHNOLOGIES LTD
A perchlorate-based fe(ii) spin crossover material and a preparation method and application thereof
ActiveCN119431223BOrganic chemistry methodsOrganic/organic-metallic materials magnetismMolecular switchSolvent
The application discloses a Fe(II) spin crossover material based on perchlorate, and a preparation method and application thereof. The application adopts a room temperature volatilization method to prepare [Fe(bamp)2]·(ClO4)2 with a higher yield, and compared with a high-temperature and high-pressure solvothermal synthesis method and a poor solvent solvent diffusion method, the method has the advantages of simple reaction condition and easy realization. The organic ligand 2,6-bis(amino methyl) pyridine has rich benzene groups and amino groups, and is easy to construct a pi-pi stacking and hydrogen bonding to finely control spin transition properties; meanwhile, ClO4 ‑ The control enhances the pi-pi intermolecular stacking effect, and under the synergistic action of the two, the material appears spin transition behavior. The Fe(II) spin crossover magnetic material has the characteristics of cheap raw materials, stable structure and performance, and the synthesized spin crossover material can be applied to the fields of molecular switch, molecular sensor and ultra-high density information storage.
Owner:QUZHOU RES INST OF ZHEJIANG UNIV
MOLECULAR SENSORS, METHOD AND KIT FOR THE DETECTION AND QUANTIFICATION OF CARBON DIOXIDE
ActiveDE602023013693T2Analysis using chemical indicatorsGroup 5/15 element organic compoundsSoftware engineeringMechanical engineering
Owner:ETH ZURICH
An asymmetric imine molecular sensor with six detection functions regulated by solvent and a preparation method and application thereof
ActiveCN120817874BOrganic compound preparationCarboxylic acid nitrile preparationSignal responseSolvent
The present application relates to the technical field of organic small molecule material detection, in particular to a solvent-regulated six-detection-function asymmetric imine molecular sensor, a preparation method and application thereof. The imine molecular sensor exhibits different fluorescence "on-off" detection responses, fluorescence "on-off" and absorption change double signal responses to acidic environment changes in 90% CH3CN aqueous solution 2+ / Co 2+ / Mn 2+ ; different fluorescence "on-off" responses, fluorescence "on-off" and absorption double signal detection performances to basic environment changes in 90% DMF aqueous solution 3+ / Cu 2+ ; and fluorescence different "on-off" detection performances of the binary system formed by the imine molecular sensor and Co 2+ / Mn 2+ to Cu 2+ , which is fast and sensitive. The imine molecular sensor provided by the present application has the advantages of mild synthesis conditions and simple preparation, thus creating favorable conditions for its popularization and application.
Owner:DEZHOU UNIV
Nanoporous graphene membrane
A nanoporous graphene film manufacturing method uses printing an array of sacrificial nanopillars of removable material on a substrate and then growing graphene. After continuous deposition of even different properties of cover layers, the sacrificial nanostructures are dissolved, ultimately forming nanoporous graphene films having nanopores, channels and cavities with designed and controlled nanoscale sizes and geometries, therefore, unprecedented unique functions can be realized in different technical fields such as filtering, electronic and molecular sensors.
Owner:OSTIA TECHNOLOGY CO LTD
Molecular sensor and molecular detection apparatus
ActiveUS12613222B2SamplingAnalysing solids using sonic/ultrasonic/infrasonic wavesHydrophobic polymerMetal-organic framework
A molecular sensor includes: a base; and a sensitive film provided above the base and containing a metal organic framework and a hydrophobic polymer, a contact angle respect to water of the hydrophobic polymer being larger than that of the metal organic framework. The metal organic framework is on the base side of the sensitive film, and the hydrophobic polymer is above the metal organic framework in the sensitive film.
Owner:KK TOSHIBA