Patents
Literature
65 results about "Molecular sensor" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
A molecular sensor or chemosensor is a molecular structure (organic or inorganic complexes) that is used for sensing of an analyte to produce a detectable change or a signal. The action of a chemosensor, relies on an interaction occurring at the molecular level, usually involves the continuous monitoring of the activity of a chemical species in a given matrix such as solution, air, blood, tissue, waste effluents, drinking water, etc. The application of chemosensors is referred to as chemosensing, which is a form of molecular recognition. All chemosensors are designed to contain a signalling moiety and a recognition moiety, that is connected either directly to each other or through a some kind of connector or a spacer. The signalling is often optically based electromagnetic radiation, giving rise to changes in either (or both) the ultraviolet and visible absorption or the emission properties of the sensors. Chemosensors may also be electrochemically based. Small molecule sensors are related to chemosensors. These are traditionally, however, considered as being structurally simple molecules and reflect the need to form chelating molecules for complexing ions in analytical chemistry. Chemosensors are synthetic analogues of biosensors, but such sensors incorporate biological receptor such as antibodies, aptamers or large biopolymers.
Imine molecular sensor with five-detection function, two-component gel and preparation method and application of two-component gel
ActiveCN120554316AOrganic chemistryMaterial analysis by observing effect on chemical indicatorUv absorbanceSignal response
The invention relates to the technical field of organic material detection, in particular to an imine molecular sensor with a five-detection function, two-component gel as well as a preparation method and application of the imine molecular sensor. The imine molecular sensor has three signal responses of fluorescence on-off, ultraviolet absorption and color change to Fe < 3 + >, Co < 2 + > and Ni < 2 + > in a solution state, and has ultraviolet absorption and fluorescence on-off dual-detection performance to acid and alkali changes; the imine molecular sensor and cholesteryl half ester can form two-component gel through a heating-low-temperature ultrasonic cooling method; after Fe < 3 + >, Co < 2 + >, Ni < 2 + >, NaOH and HCl are respectively added, the orange of the gel becomes milky white, reddish brown, transparent red, milky white and milky white under sunlight, and the fluorescence of the orange of the gel disappears under an ultraviolet lamp, so that the rapid and sensitive detection of Fe < 3 + >, Co < 2 + >, Ni < 2 + >, acid and alkali under two states of the imine molecular solution and the gel is realized. The imine molecular sensor provided by the invention has the advantages of mild synthesis conditions, simple preparation and the like, and creates favorable conditions for popularization and application of the imine molecular sensor.
Owner:DEZHOU UNIV
FRET-based botulinum toxin type A and E detection molecular sensor and application thereof
The invention belongs to the technical field of medicines, and particularly relates to an FRET (Fluorescence Resonance Energy Transfer)-based botulinum toxin A and E detection molecular sensor and application thereof. The invention accidentally finds that the BoNT / A or BoNT / E biological activity detection molecular sensor is prepared by taking EGFP / DsRED as donor and receptor fluorophores and SNAP-25 (141-206aa) as a connexon through an after-ripening process, and the detection molecular sensor has the characteristics of high signal-to-noise ratio, rapidness, simplicity, convenience, sensitivity, good accuracy, high sensitivity, good repeatability and high stability. The biological activity or content detection on BoNT / A or BoNT / E at a molecular level can be realized; the kit can be applied to detection of the biological activity of the light chain in the preparation process of BoNT / A or BoNT / E extracted by a recombination or traditional method, can also be used for in-vitro screening of botulinum toxin inhibitors, and can also be used for poisoning diagnosis of BoNT / A or BoNT / E.
Owner:LANZHOU UNIV +1
Aptamer-capture agent-based molecular sensors and methods of use
PCT designated stage expiredWO2025029630A2Polypeptide with localisation/targeting motifImmunoglobulin superfamilyAptamerEpitope
Provided are molecular sensors comprising a capture agent that binds to a first epitope of an analyte, and an aptamer that binds to a second epitope of the analyte. The aptamer is stably associated with the capture agent and produces a detectable signal upon cooperative binding of the capture agent and aptamer to the analyte. Also provided are substrates comprising a molecular sensor of the present disclosure immobilized on the surface thereof, as well as devices comprising the molecular sensors and substrates. Methods of using the molecular sensors, substrates and devices of the present disclosure are also provided. In some instances, the methods are for assessing a sample for an analyte, the methods comprising contacting a molecular sensor of the present disclosure with the sample under conditions suitable for cooperative binding of the capture agent and aptamer to the analyte, and assessing for a detectable signal produced by the aptamer.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
A graphene composite film and its preparation method and application
The present invention relates to the technical field of graphene composite film preparation, and more particularly to a graphene composite film, its preparation method, and its applications. The present invention utilizes multiple modification processes, including amino lignin modification, carbon nanotube modification, polyimide modification, and glutaraldehyde-crosslinked polystyrene sulfonic acid modification, to prepare the graphene composite film. By optimizing the raw material ratio and preparation process, the graphene composite film significantly improves its tensile strength, elongation at break, electrical conductivity, and thermal stability, showing promising application prospects in molecular devices such as molecular sensors and molecular field-effect transistors.
Owner:LULIANG UNIV
Graphene single-molecule sensing device based on pillararene as well as preparation method and application of graphene single-molecule sensing device
The invention relates to the technical field of single-molecule devices and sensors, in particular to a graphene single-molecule sensing device based on pillararene as well as a preparation method and application of the graphene single-molecule sensing device. The sensor comprises a pillararene molecule, the functional molecule is covalently connected between a graphene electrode pair through nucleophilic substitution reaction or amide condensation reaction under an alkaline condition, and the stability and the conductive reliability of a molecule-electrode interface are enhanced. According to the present invention, the column aromatic hydrocarbon molecules can selectively perform inclusion on the perfluorocarboxylic acid, and the combination of different types of perfluorocarboxylic acids and the column aromatic hydrocarbon molecules can show the difference characteristic of the conductive state so as to achieve the distinguishing of different perfluorocarboxylic acids, such that the method is hopeful to be used in the detection of perfluorocarboxylic acid. Meanwhile, perfluorocarboxylic acid can be effectively desorbed through methanol treatment, and an I-V signal is recovered to an initial state, so that the device has reusability. The preparation method provided by the invention is stable in process, high in repeatability and beneficial to large-scale production.
Owner:NANKAI UNIV
Enzymatic circuits for molecular sensors
ActiveUS12247251B2Sugar derivativesMicrobiological testing/measurementConduction pathwayHemt circuits
In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.
Owner:SEMICONBIO INC
Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.
Owner:TRUSTEES OF BOSTON UNIV
Enzymatic Circuits For Molecular Sensors
PendingUS20250179551A1Sugar derivativesMicrobiological testing/measurementConduction pathwayHemt circuits
In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.
Owner:SEMICON BIO
High throughput nucleic acid sequencing with single molecule sensor array
The invention relates to high throughput nucleic acid sequencing with a single molecule sensor array. Embodiments of single molecule array sequencing (SMAS) devices and systems are disclosed herein. Each sensor in a sensor array of the SMAS device is capable of detecting a label attached to a nucleotide incorporated into a single nucleic acid strand that binds to a respective binding site. Each sensor may detect a single label (e.g., fluorescent, magnetic, organometallic, charged molecules, etc.) attached to the incorporated nucleotides. Also disclosed are methods of highly tunable nucleic acid (e.g., DNA) sequencing based on synthetic sequencing (SBS) of various examples of colonized amplified DNA immobilized on such SMAS devices using the SMAS devices and systems. Also disclosed are error correction methods that mitigate errors generated in sequencing individual nucleic acid strands (e.g., detecting or not detecting error markers).
Owner:F HOFFMANN LA ROCHE & CO AG +1
Molecular sensors and related methods
ActiveUS12607593B2Microbiological testing/measurementMaterial analysis by electric/magnetic meansGap junctionDNA
Electronic sensors configured to detect single molecules and DNA methods of using and manufacturing same are disclosed. A sensor may include source and drain electrodes spaced apart by a sensor gap; a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit; and a bridge molecule bridging across the sensor gap, connecting source and drain electrodes; and a probe coupled to the bridge molecule, wherein interaction of the probe with a nucleic acid is detectable by monitoring a parameter of the electrode circuit. In various examples, the nucleic acid comprises DNA or RNA.
Owner:SEMICONBIO INC
Imidazole-based functionalized covalent organic framework material as well as preparation method and application thereof
The invention belongs to the technical field of functionalized covalent organic framework material design and photophysical regulation and control, and particularly relates to an imidazole-based functionalized covalent organic framework material as well as a preparation method and application thereof. An imidazole group is integrated into a COF skeleton, so that the pi electron conjugation effect of the material is remarkably enhanced, the fluorescence emission wavelength is subjected to red shift, the fluorescence intensity is improved, the material shows an adjustable fluorescence behavior in a solvent polar environment, the specific surface area of the material can reach 635 m < 2 > / g, the pore size distribution can reach 1.78 nm, the material is suitable for specific detection of Cu < 2 + >, the detection limit is as low as 2 nM, and the material has good application prospects. And the catalyst is stable under strong acid, strong alkali and high temperature. The preparation method has the advantages that the synthesis process is simple, the material stability is high, the fluorescence performance can be accurately regulated and controlled, the prepared material is suitable for the fields of photoelectric equipment, molecular sensors, fluorescence probes and the like, and a new strategy can be provided for development of high-performance optical materials and detection of heavy metal ions in the environment.
Owner:LULIANG UNIV
FRET biosensor and preparation method and application thereof
PendingCN121431454AFluorescence/phosphorescenceVector-based foreign material introductionSignal responseLiving cell
The invention discloses an FRET (Fluorescence Resonance Energy Transfer) biosensor as well as a preparation method and application thereof. The FRET biosensor is obtained by transfecting cells with plasmids for expressing a molecular sensor; the molecular sensor contains NEK7 protein, a fluorescence donor and / or a fluorescence receptor, and the fluorescence donor or the fluorescence receptor is connected to the N end or the C end of the NEK7 protein through a flexible chain. According to the invention, the FRET biosensor is designed, and multiple conditions are optimized, so that the signal response efficiency of the FRET biosensor is improved, and meanwhile, real-time monitoring of NLRP3 oligomerized living cells is realized, and screening of an NEK7-NLRP3 protein interaction interference inhibitor is realized.
Owner:CHINA PHARM UNIV
Polyion elastomer material as well as preparation method and application thereof
InactiveCN119505120Aincrease elasticityImprove flexibilityForce measurement using piezo-resistive materialsElastomerPolymer science
The invention belongs to the field of flexible polymer sensor materials, and relates to a polyion elastomer material as well as a preparation method and application thereof. The rigid chain segment of the polymerizable ionic liquid and the flexible chain segment of the polymerizable polyether cross-linking agent are combined through C = C double bonds for the first time, and the polyion elastomer material of a network structure is formed through photopolymerization; the ether bond is used for providing excellent elasticity and good flexibility for the polyion elastomer, is used for adjusting the compression elastic modulus of the polyion elastomer, and is also directly used as a cross-linking agent component to form a polyion elastomer network structure; and the polymerizable ionic liquid also endows the polyion elastomer with good conductivity. The preparation method disclosed by the invention is simple and easy to industrialize, and does not need complex auxiliaries; the prepared polyion elastomer material has the advantages of low hysteresis, high stability and ultrafast response rate, is especially suitable for flexible pressure sensors, and can be further used for flexible wearable equipment.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA
An imine molecular sensor with five detection functions, a two-component gel, and its preparation method and application
ActiveCN120554316BOrganic chemistryMaterial analysis by observing effect on chemical indicatorUv absorbanceSignal response
The present invention relates to the technical field of organic material detection, and in particular to an imine molecular sensor with five detection functions, a two-component gel, and a preparation method and application thereof. 3+ 、Co 2+ 、Ni 2+ It has three signal responses: fluorescence on-off, ultraviolet absorption, and color change, and has dual detection performance of ultraviolet absorption and fluorescence on-off for acid and alkali changes; the imine molecular sensor and cholesterol half ester can form a two-component gel through heating-low temperature ultrasonic cooling method; Fe 3+ 、Co 2+ 、Ni 2+ After the addition of NaOH and HCl, the orange-yellow color of the gel changes to milky white, reddish brown, transparent red, milky white, and milky white under sunlight, and the orange-red fluorescence of the gel disappears under ultraviolet light, realizing the dual state of the imine molecule solution and gel for Fe 3+ 、Co 2+ 、Ni 2+ The imine molecular sensor provided by the present invention has the advantages of mild synthesis conditions and simple preparation, which creates favorable conditions for its promotion and application.
Owner:DEZHOU UNIV
Molecular detection apparatus, molecular detection method, and molecular detection system
PendingUS20250297933A1Material analysis using sonic/ultrasonic/infrasonic wavesAnalysing gaseous mixturesAnalytical chemistryPhysics
A molecular detection apparatus includes: a detection unit comprising first and second molecular sensors having first and second sensitive films, the first and second molecular sensors being same in detection principle and different in responsiveness; and a processing device to perform calibration using first and second response signals from the first and second molecular sensors. The processing device uses data ΔFS and ΔFR of the first and second response signals which are acquired in a first period when carrier gas not containing the target molecule is supplied to derive a relational expression for approximating ΔFS to a function including ΔFR, approximates ΔFS acquired in a second period when carrier gas containing the target molecule is supplied and the first period according to the relational expression to acquire data ΔFSX of a calibration response signal, and acquire differential data between ΔFSX and ΔFS as data ΔFSY of an apparent response signal.
Owner:KK TOSHIBA
STM-BJ-based single-molecule sensor and application thereof
The invention discloses a single-molecule sensor based on STM-BJ and application of the single-molecule sensor, and belongs to the technical field of analytical chemistry. On the basis that 1, 3-bis (pyridine-4-yl) propane-diketone interacts with alcohols under the conditions of applying negative bias and applying a sodium sulfate aqueous solution to form a supramolecular junction, a supramolecular strategy is introduced into a gap between a probe and a sample table in STM-BJ, and specific single molecule detection of alcohol molecules is realized by using a negative bias working mode of STM. Compared with other traditional research means, the method provided by the invention not only can accurately identify alcohol molecules, has high sensitivity, but also can realize quantitative analysis of alcohols.
Owner:GUANGDONG UNIV OF TECH
Method for providing a molecular sensor, molecular sensor obtained and method for detecting an analyte by means of that molecular sensor
A method for providing a capacitive sensor having a molecularly imprinted polymer detection element for detecting a desired analyte, comprising the following steps: - providing a capacitive sensor comprising a pair of electrodes and a sensitive element which is made of polymer material and which is connected to said pair of electrodes, - processing said capacitive sensor in order to pre-functionalize said polymer material of said sensitive element in order to bond at least one functional group to said polymer material of said sensitive element and to obtain a pre-functionalized polymer material, - bonding said pre-functionalized polymer material to a molecularly imprinted polymer (MIP), said molecularly imprinted polymer having at least one receptive site for a desired analyte so as to obtain a capacitive sensor which is provided with a molecularly imprinted polymer detection element suitable for detecting said analyte.
Owner:MORESENSE SRL
Terahertz bielliptical all-dielectric metasurface chiral molecular sensor
PendingCN119595586AHigh detection sensitivityflexible structurePolarisation-affecting propertiesRefractive indexParticle physics
The invention discloses a terahertz bielliptical all-dielectric metasurface chiral molecular sensor, and relates to the field of optical sensors. The sensor is composed of a substrate made of a low-refractive-index medium (such as silicon dioxide or calcium fluoride) and resonator units periodically arranged above the substrate. Each resonator unit is composed of two symmetrically-arranged high-refractive-index medium (such as silicon or germanium) resonators, the two resonators are in an oval shape, and a slit area is formed between the two resonators. When circularly polarized terahertz waves are incident, the metasurface generates Mie resonance, and strong single-symbol touchable terahertz chiral light field hot spots are formed in a slit area, so that ultra-sensitive detection of chiral molecules is realized. The sensor is symmetrical and simple in structure, can realize remarkable enhancement of an electric field, a magnetic field and a chiral light field in a terahertz wave band, and has an important application prospect in terahertz ultra-sensitive chiral sensing detection.
Owner:XIAMEN UNIV
High throughput stochastic bio-molecular sensor
ActiveUS12578328B2Component separationMaterial analysis by electric/magnetic meansSensor arrayBio molecules
What is described herein is a device for sensing a target, comprising a planar array of unique stochastic sensors, wherein each sensor is weakly cross-reactive with a unique determinant on the target; a means for capturing electrical signals from each sensor and the temporal duration of each signal; and a means for analyzing the cumulative signals from the array of stochastic sensors, and optionally further comprising a computer system for processing an algorithm for identifying the target based on the electrical signals from the sensors of the device.
Owner:MASSACHUSETTS INST OF TECH
A biochemical molecule detection method based on the quantum capacitance effect of conductive composite materials
The present invention discloses a method for detecting biochemical molecules based on the quantum capacitance effect of conductive composite materials, which belongs to the field of molecular sensor technology. A three-electrode system consisting of a working electrode, a reference electrode, and a counter electrode is used for testing. A solution is dripped into a liquid tank so that both the working electrode and the reference electrode are in contact with the solution to form a circuit. A phase-locked amplifier or an impedance analyzer is used for quantum capacitance testing. Based on the test results, the liquid environment in which the sensor is located is evaluated to detect the concentration of biochemical molecules in the liquid. The present invention is easy to prepare, has a controllable structure, high stability, and good biocompatibility. It can realize Internet-style instant sensing and information communication and has extremely high detection sensitivity.
Owner:TSINGHUA UNIVERSITY
Portable fluorescence sensor for rapidly and intelligently detecting sulfite content in food and preparation method of portable fluorescence sensor
PendingCN121783926AMaterial analysis by observing effect on chemical indicatorFluorescence/phosphorescenceBiotechnologyBisulfide
The invention discloses a portable fluorescence sensor for rapidly and intelligently detecting the content of sulfite in food and a preparation method thereof. The sensing chip has specific interaction with sulfite (bisulfite) through the molecular sensor LCMQ, changes of dual optical signals of color and fluorescence are generated, and the content of sulfite (bisulfite) in food is quantitatively detected through capture, recognition and analysis of a portable instant detection platform of a sensing chip-smart phone. The method has the characteristics of simplicity in preparation, low cost, high sensitivity, high selectivity, rapidness and readability, provides an intelligent and effective means for detection of sulfite (bisulfite) in food, provides powerful technical guarantee for self-monitoring and market supervision of food manufacturers, has great application prospects, and has great popularization significance.
Owner:GUANGXI UNIV
A molecular sensor and methods for use
PendingUS20250298014A1Microbiological testing/measurementBiological testingConduction pathwayHemt circuits
In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.
Owner:SEMICONBIO INC
Molecular sensor for detecting methane and / or carbon dioxide dissolved in a liquid
PCT designated stageWO2025190891A1Analysing fluids using sonic/ultrasonic/infrasonic wavesQuartz crystal resonatorMetal-organic framework
Disclosed is a molecular sensor for detecting molecules dissolved in liquid, the molecular sensor comprising: a sensor housing, a measurement chamber comprised in the sensor housing and being fluidly coupled to an exterior of the sensor housing, and a quartz crystal microbalance (QCM). A quartz crystal resonator comprised in the QCM is functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and / or reversibly adsorb carbon dioxide, and the molecular sensor is configured such that liquid which enters the measurement chamber can come in direct contact with a surface of the MOF. Also disclosed is a method of detecting and / or quantifying molecules dissolved in a liquid, the method comprising the steps of: providing a molecular sensor comprising a quartz crystal microbalance (QCM), the QCM comprising a quartz crystal resonator, the QCM being functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and / or reversibly adsorb carbon dioxide; providing the liquid to a functionalised surface of the QCM such that the liquid directly contacts the functionalised surface.
Owner:DANMARKS TEKNISKE UNIV
A base recognition method based on semiconductor SERS technology
The application discloses a base recognition method based on semiconductor SERS technology and belongs to the technical field of biomedical detection. The specific method comprises the following steps: step one, synthesis of TiO2 nanoparticles; step two, preparation of a TiO2 / 4-MBA system; and step three, base recognition detection. The TiO2 / MBA system can be used for accurate and rapid DNA base recognition, and the developed TiO2 / MBA system is simple to prepare and has excellent base test performance, and has a high market application prospect. The application not only provides a novel base detection method, but also has high sensitivity and selectivity, can recognize and detect four bases and the non-covalent interaction between the four bases and 4-MBA in two pH environments, and has a simple and rapid operation process. The application not only provides a new method for base analysis, but also provides technical support for early diagnosis of DNA related diseases, genomics research and development of molecular sensors, and has a wide application prospect.
Owner:NORTHEAST FORESTRY UNIV
Multifunctional Molecular Sensor for Detecting Polar, Viscosity or Hydrazine Components in Soil or Water Body, and Preparation and Application Thereof
The present invention discloses a multifunctional molecular sensor for detecting polar, viscosity or hydrazine components in soil or water, and its preparation and application. The structure of the molecular sensor provided by the present invention contains multiple rotatable aromatic rings and conjugated structures, and has typical twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) characteristics. It can not only respond to the polarity and viscosity of soil or water, but even to hydrazine, a pollutant. It has multiple response functions and can assist in evaluating the physical state of the microenvironment, the microplastic adsorption behavior and the degree of contamination by hydrazine in soil and water through the detection results, and can be used as one of the important evaluation tools for soil and water safety monitoring.
Owner:JINGGANGSHAN UNIVERSITY
Nanoporous membrane
A method of making a nanoporous membrane is constructed using an array of sacrificial nanopillars that print removable material on a substrate. After continuous deposition or even of covering layers with different properties, the sacrificial nanostructure is dissolved, and finally the nanoporous membrane with nanopores, channels and cavities designed with nanoscale sizes and geometrical shapes is formed. Thus, unprecedented unique functions are achieved in various technical fields (e.g., bioartificial organs, nanoelectronics, bioelectronics, molecular sensors and biomedical applications).
Owner:OSTIA TECHNOLOGY CO LTD
Oxygen molecule sensor based on graphene / metalloporphyrin and preparation method thereof
The invention relates to an oxygen molecule sensor based on graphene / metalloporphyrin and a preparation method thereof. The oxygen molecule sensor comprises a substrate layer, a graphene layer, an epoxy resin layer, a metal electrode and recognition probe molecules, the graphene layer is made of single-layer graphene; the identification probe molecule comprises the following components: heme, FeTPPCl, CuTPP, NiTPP, and CoTPP. The graphene / metalloporphyrin oxygen molecule sensor prepared by the invention is high in sensitivity, and can also be used for detecting gas-phase and liquid-phase oxygen molecules at the same time.
Owner:XINJIANG INST OF ENG
Graphene composite film and preparation method and application thereof
The invention relates to the technical field of graphene composite film preparation, in particular to a graphene composite film and a preparation method and application thereof. According to the preparation method disclosed by the invention, the graphene composite film is prepared by utilizing various modification processes such as aminated lignin modification, carbon nanotube modification, polyimide modification and glutaraldehyde cross-linked polystyrene sulfonic acid modification; the tensile strength, the elongation at break, the electric conductivity and the heat conduction stability of the graphene composite film are remarkably improved, so that the graphene composite film has a good application prospect in molecular devices such as molecular sensors and molecular field effect transistors.
Owner:LULIANG UNIV
Membrane tension response type composite molecular sensor as well as preparation method and application thereof
PendingCN121406756AMicrobiological testing/measurementFluorescence/phosphorescenceMembrane tensionCholesterol
The invention discloses a membrane tension response type composite molecular sensor and a preparation method and application thereof, the membrane tension response type composite molecular sensor comprises a DNA tetrahedral framework formed by a plurality of single-stranded DNAs through complementary base pairing, and the single-stranded DNAs comprise single-stranded DNAs modified with vibration luminescent molecules, single-stranded DNAs modified with cholesterol molecules and unmodified single-stranded DNAs; the vibration luminescent molecule is loaded on the end point of one single-stranded DNA through covalent modification, and the cholesterol molecule is loaded on the end point of the other single-stranded DNA through covalent modification; the vibration light-emitting molecules are excited by single laser, switching between bending conformation and torsional conformation occurs, and then cell membrane tension is responded through emission wavelength intensity change. The membrane tension response type composite molecular sensor has the advantages of being controllable in size, high in brightness, high in cell membrane targeting performance and the like, fluorescence proportion imaging of cell membrane tension is achieved, and the huge potential of the membrane tension response type composite molecular sensor in research and application of the life process of stem cells is revealed.
Owner:SHANGHAI JIAOTONG UNIV
High-throughput nucleic acid sequencing with single-molecule sensor arrays
Embodiments of single molecule array sequencing (SMAS) devices and systems are disclosed herein. Each sensor in the sensor array of the SMAS device is capable of detecting a label attached to a nucleotide incorporated into a single nucleic acid chain bound to a respective binding site. Each sensor can detect a single label (e.g., fluorescent, magnetic, organic metal, charged molecule, etc.) attached to the incorporated nucleotide. Also disclosed are methods for highly adjustable nucleic acid (e.g., DNA) sequencing based on synthetic sequencing (SBS) of multiple examples of cloned amplified DNA fixed on such a SMAS device using a SMAS device and system. Also disclosed are error correction methods that mitigate errors (e.g., detection or non-detection of erroneous labels) generated in sequencing individual nucleic acid chains.
Owner:F HOFFMANN LA ROCHE & CO AG +1