Zinc-quercetin nanocomplex, method of preparation and medical use thereof

By coordinating and self-assembling zinc-quercetin nanocomposites, the problems of poor water solubility of quercetin and limited analgesic effect of zinc ions have been solved, achieving efficient and safe treatment of chronic pain and avoiding the side effects of traditional drugs.

CN122297456APending Publication Date: 2026-06-30NANTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANTONG UNIV
Filing Date
2026-03-31
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Quercetin has extremely low solubility in water, making it difficult to achieve effective therapeutic concentrations. Traditional carrier encapsulation methods increase costs and potential toxicity, while free zinc ions have limited analgesic effects and are difficult to concentrate.

Method used

Through the coordination self-assembly of zinc-quercetin nanocomposites, a stable nanocomposite is formed, which combines the synergistic analgesic effects of quercetin and zinc ions to achieve water solubility and colloidal stability, avoiding the toxicity introduced by the carrier.

Benefits of technology

This approach achieves high bioavailability and sustained analgesic effect of quercetin, avoids the side effects of traditional drugs, and provides a safe and long-lasting treatment option for chronic pain.

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Abstract

This invention discloses a zinc-quercetin nanocomposite, its preparation method, and its pharmaceutical applications, belonging to the field of bionanomaterials technology. This nanoparticle employs a carrier-free self-assembly strategy, directly forming a structurally stable nanocomposite by combining the natural flavonoid quercetin with zinc ions through metal-organic coordination bonds. This technology effectively overcomes the inherent defects of poor water solubility and low bioavailability of quercetin monomers, resulting in a nanocomposite with good water solubility and physiological stability. Simultaneously, zinc ions, as a key trace element for neuroregulation, can intervene in pain transmission pathways to alleviate pain; quercetin exerts a long-lasting anti-inflammatory and analgesic effect by continuously scavenging reactive oxygen species and inhibiting the release of inflammatory factors in damaged nerves or inflammatory sites. The two work synergistically in the lesion microenvironment, achieving the prevention and efficient, safe treatment of chronic pain. The preparation process is extremely simple, requiring no complex carriers, and has broad prospects for clinical translation and application.
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