A signal probe capable of both CT and MRI imaging, its preparation method, and its application.

By adjusting the molar ratio of bismuth citrate and iron salt to prepare bismuth-iron nanoparticles, and modifying their surface with PEG and RGDfk, the problems of insufficient particle size control and imaging sensitivity of existing CT/MRI dual-modal nanoimaging probes are solved, enabling efficient imaging and early diagnosis of multiple lesions in prostate cancer.

CN122075745APending Publication Date: 2026-05-26NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
Filing Date
2026-03-05
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing CT/MRI dual-modal nanoimaging probes have shortcomings in preparation methods, particle size control, and imaging sensitivity, making it difficult to meet the needs of early and accurate diagnosis of multiple lesions in prostate cancer.

Method used

By adjusting the molar ratio of bismuth citrate and iron salt, bismuth-iron nanoparticles were prepared under weakly alkaline conditions, and PEG and RGDfk were modified on their surface to prepare signal probes with small particle size and excellent CT and MRI imaging performance.

Benefits of technology

It achieves efficient imaging and early diagnosis of multiple lesions in prostate cancer, significantly improving the accuracy and reliability of diagnosis of multiple lesions in tumors. The nanoparticles are enriched in the tumor site, overcoming the problem of limited information in a single imaging mode.

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Abstract

This invention belongs to the field of biomedical materials technology, and relates to a signal probe that simultaneously possesses CT and MRI imaging capabilities, its preparation method, and its application. The preparation method includes the following steps: dissolving bismuth citrate and iron salt in water, adjusting the pH of the solution to <7, adding polyvinylpyrrolidone, then adding gallic acid, adjusting the pH of the mixed solution to >7, and after the reaction is complete, filtering through a membrane to remove impurities, dialysis, and drying to obtain bismuth-iron nanoparticles; mixing citric acid with the bismuth-iron nanoparticle solution, stirring and reacting to obtain citric acid-treated bismuth-iron nanoparticles; further activating to obtain an activated bismuth-iron nanoparticle solution; adding RGDfk and amino-terminated polyethylene glycol to the activated bismuth-iron nanoparticle solution, stirring and reacting in the dark, dialysis, and drying to obtain a signal probe that simultaneously possesses CT and MRI imaging capabilities. The signal probe prepared by this invention has a small particle size and simultaneously possesses CT and MRI imaging functions.
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