Porous microneedle array based on metal sintering and manufacturing method thereof

A microneedle array and metal sintering technology, which is applied in the field of biomedical engineering, can solve the problems of a large difference in the strength of the microneedle array and the microneedle, the inability to effectively output a large amount of drugs, and the inability to deliver drugs, etc. High-dose, high-intensity effects

Active Publication Date: 2016-06-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, metal is an ideal material for making microneedle arrays. For example, Chinese patent CN201210316602.9 discloses a method for preparing titanium solid microneedles for transdermal drug delivery. To prepare a solid titanium alloy microneedle array, but this scheme cannot effectively output a large amount of drugs
Chinese patent CN201010204631.7 discloses a method for preparing an off-surface hollow microneedle array for transdermal drug delivery. In order to improve the accuracy of hole formation, the hole is punched by mask marking to form a titanium-based off-surface Hollow array, but the microneedle strength of the microneedle array obtained by this scheme is quite different from that of the solid microneedle
[0008] All in all, the microneedle arrays processed by common metal processing techniques such as etching and laser engraving include solid needles and hollow needles. A large number of drugs, and the hollow needle can be used as a microneedle injection device, but the mechanical properties are slightly insufficient

Method used

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  • Porous microneedle array based on metal sintering and manufacturing method thereof
  • Porous microneedle array based on metal sintering and manufacturing method thereof
  • Porous microneedle array based on metal sintering and manufacturing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] The manufacturing equipment of the manufacturing method of the metal porous microneedle array made by metal sintering includes a base mold, a ventilated drying oven for evaporating liquid, and a high-temperature sintering furnace for metal sintering, wherein the base mold is such as figure 1 and 2 As shown, a mold body 1 made of polydimethylsiloxane is included, a recess 2 is provided in the mold body, and the hole 3 is provided on the bottom surface of the recess 2 . Specifically, the depth of the concave portion 2 is 2mm, which is to ensure that enough metal titanium powder is filled in the concave portion 2 and the hole 3 after the substrate mixed solution is evaporated to dryness. The holes 3 are arranged in a structure of 6*6, the shape of a single hole 3 is conical, the diameter of the bottom surface is 0.45mm, and the depth is 500um. In this embodiment, the selection of the diameter of the bottom surface is very important, which not only determines and affects t...

Embodiment 2

[0059] The operation method of this embodiment is similar to that of Embodiment 1, the difference is that in this embodiment, a small hole with a diameter of 0.5 mm is selected, and the hole distance is 0.5 mm. The hole distance refers to the shortest distance between the edges of adjacent holes. 49 small holes are evenly distributed on the mold body 1, 7 holes in each row, 7 rows in total. In the present embodiment, the content of metal titanium powder particles (particle diameter 0.2um) in the base mixed solution is 42%, the ethanol content is 48%, the plasticizer is selected dihexyl phthalate, and the content is 1.2%. The agent is polyvinyl alcohol (molecular weight 120,000 to 150,000) and the dosage is 7%, the dispersant is polyethylene glycol (molecular weight 190-210) and the dosage is 1%, and the sintering synergist is selected with kaolin content of 0.8%. The microneedle array obtained after sintering also has similar properties to Example 1.

Embodiment 3

[0061] The operation method of this embodiment is similar to that of Embodiment 1, the difference is that in this embodiment, small holes with a diameter of 0.6mm are selected, and the hole distance is 0.7mm, and 25 small holes are evenly distributed on the mold body 1, and each row 5 total of 5 lines. In the present embodiment, the content of metal titanium powder particles (particle diameter 0.4um) in the base mixed solution is 40%, the ethanol content is 49%, the plasticizer is selected dibutyl phthalate, and the consumption is 2.4%, the bonding The agent is carboxymethyl cellulose with an amount of 6.5%, the dispersant is polyethylene glycol (molecular weight 190-210) with an amount of 1.1%, and the sintering synergist is selected with a kaolin content of 1%. After the sintering process, the cooling rate was adjusted to 5° C. / min, and the performance of the microneedle array prepared according to Example 3 was similar to that of Example 1.

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Abstract

The invention discloses a manufacturing method of a porous microneedle array based on metal sintering. The manufacturing method comprises the following steps that firstly, base mixed liquor is prepared and poured into a base mold, and the bottom of the base mold is provided with multiple conical holes used for manufacturing microneedles; secondly, the base mold with the base mixed liquor poured in the first step is aerated and dried, and a microneedle array obtained after drying and molding are conducted is taken out of the base mold; and thirdly, the microneedle array obtained in the second step is sintered, so that the metal porous microneedle array is obtained. By the adoption of the manufacturing method of the porous microneedle array based on metal sintering, the technology is simple, the structure is stable and the metal strength is high.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, and more specifically, to a metal-based sintered porous microneedle array and a manufacturing method thereof. Background technique [0002] Among the treatment methods at this stage, drug therapy is the most common treatment method. Its therapeutic principle is to transfer the drug from the outside of the body to the human body through a certain transport method to produce the drug effect. The more common drug delivery methods in drug therapy mainly include injection drugs, oral tablet administration and transdermal drugs. The therapeutic effect of the drug does not only depend on the drug itself, but the influence of the transport mode on the drug is also a key factor in determining the therapeutic effect. [0003] Injection is the most direct way of drug administration, but injection will bring some pain to patients, and the first-pass effect of the liver will reduce the therap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F3/22B22F3/11B22F1/00A61M37/00
CPCA61M37/0015B22F3/1103B22F3/22A61M2037/0053B22F2998/10B22F1/107
Inventor 蒋乐伦李冀豫宋振华
Owner SUN YAT SEN UNIV
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