Method for preparing off-plane hollow microneedle array for use in transdermal medicament administration

Abstract

The invention discloses a method for preparing an off-plane hollow microneedle array for use in transdermal medicament administration, which comprises: growing a mask film on one side of a metal substrate, defining a microneedle array pattern to form a mask film pattern, and forming a perforation mark which is aligned with the mask film pattern on the other side of the metal substrate; protectingthe side with the perforation mark, and etching the metal substrate till the mask film falls off to form the off-plane microneedle array; and removing the protection of the side with the perforation mark, and performing perforation according to the perforation mark to form the off-plane hollow microneedle array. In the invention, based on a micromechanical process and a positioning perforation technique, the off-plane microneedle array preparation is realized, the process is simple, the processing process of the metal substrate body of off-plane hollow microneedles is made possible, he manufacturing level of the off-plane hollow microneedles is improved greatly, and the reliability and insertion property of the microneedle array are improved.

Description

technical field [0001] The invention relates to micromachining technology, in particular to a method for preparing a hollow microneedle array for transdermal administration. Background technique [0002] At present, the main modes of administration are oral and injection. Due to the gastrointestinal absorption and the first-pass effect of the liver, as well as the obvious pain caused by the injection and the need for professional operation, the microneedle transdermal drug delivery between subcutaneous injection and transdermal patch has become a better solution. [0003] The size of the microneedles is on the order of microns, and through painless pore-forming treatment of the skin, tiny pores are created in the stratum corneum without blood vessels and nerves to improve the permeability of drugs. Due to the extremely small size of the needle tip, there is almost no damage to the skin, and it does not require professional training, so it is easy to use. [0004] From the ...

AI Technical Summary

Problems solved by technology

Kiyoshi Sawada et al. have made hollow microneedle arrays by plastic injection molding, which requires ultra-precision machining capabilities and high costs (Kiyoshi Sawada, et al.Micro structuring of high aspect ratio and array by means of mechanical machine.Int.Conf .Pre Engineering (ICPE), July 18-20, 2001.)

LIGA and improved LIGA technology are more difficult, cost more, and cost relatively high

At the same time, the bonding strength between the electroplated needle body and the substrate is not as high as the reliability of the overall processing technology.

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