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Calophyllum inophyllum kernel oil included lecithin liposome and application thereof in soothing scar-fading products

A lecithin and liposome technology, which is applied in the field of daily chemicals, can solve the problems of poor slow-release effect and poor effect of daily chemicals on smoothing and scarring.

Active Publication Date: 2016-06-15
上海京樾医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a lecithin liposome embedded with crabapple fruit oil and its application in smoothing and scar-reducing products. Phospholipid liposomes and their application in products for smoothing and lightening scars will solve the technical problems of poor slow-release effects of slow-release carriers in the prior art and poor effects of daily chemicals for smoothing and lightening scars

Method used

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  • Calophyllum inophyllum kernel oil included lecithin liposome and application thereof in soothing scar-fading products
  • Calophyllum inophyllum kernel oil included lecithin liposome and application thereof in soothing scar-fading products

Examples

Experimental program
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Effect test

Embodiment 1

[0130] A lecithin liposome embedding crabapple fruit oil is prepared by the following method:

[0131] (1), 3.0g glyceryl caprylate, 2.5g blue light nanoemulsifier, 4.0g solubilizer, 1.0g glycerol monostearate, 4.0g glycerin, 0.05g antioxidant 2,6-di-tert-butyl Put hydroxytoluene, 0.3g of preservatives, namely 0.2g of methylparaben and 0.1g of propylparaben into a beaker, heat and stir in a water bath at about 60°C until completely dissolved to obtain a liquid oil phase;

[0132] (2) After cooling down, add 3.5g of crabapple oil and 3.0g of lecithin into the above liquid oil phase, heat and stir at low temperature until completely dissolved to obtain a homogeneous system;

[0133] (3), 78.65g of deionized water is used as the water phase, and the obtained homogeneous system is the same as water, and the water bath is heated to the emulsification temperature;

[0134] (4) Take the homogenizer, add the homogeneous system obtained in step (3) into the water phase obtained in ste...

Embodiment 2

[0136] A lecithin liposome embedding crabapple fruit oil is prepared by the following method:

[0137] (1), 4.0g glyceryl caprylate, 3.0g blue light nanoemulsifier, 5.0g solubilizer, 1.0g glycerol monostearate, 5.0g glycerin, 0.05g antioxidant 2,6-di-tert-butyl Put hydroxytoluene, 0.3g of preservatives, namely 0.2g of methylparaben and 0.1g of propylparaben into a beaker, heat and stir in a water bath at about 60°C until completely dissolved to obtain a liquid oil phase;

[0138] (2) After cooling down, add 5.0g of crabapple fruit oil and 4.0g of lecithin into the above liquid oil phase, heat and stir at low temperature until completely dissolved to obtain a homogeneous system;

[0139] (3), 72.65g of deionized water is used as the water phase, and the obtained homogeneous system is the same as water, and the water bath is heated to the emulsification temperature;

[0140] (4) Take the homogenizer, add the homogeneous system obtained in step (3) into the water phase obtained ...

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Abstract

The invention provides calophyllum inophyllum kernel oil included lecithin liposome having a core-shell structure. A core of the liposome is composed of calophyllum inophyllum kernel oil, a shell thereof is composed of lecithin, and the liposome is 19.99-72.70 nm in average particle size and 30-50% in inclusion rate. Further provided is a preparation method of the calophyllum inophyllum kernel oil included lecithin liposome and application of the calophyllum inophyllum kernel oil included lecithin liposome in soothing scar-fading products, the calophyllum inophyllum kernel oil included lecithin liposome has a percent-by-mass concentration of 30-50% in a soothing scar-fading product, and the soothing scar-fading product is scar cream, scar milk or scar gel. The liposome of the invention not only has better stability of the included active ingredient, calophyllum inophyllum kernel oil, but also can release slowly; meanwhile, the calophyllum inophyllum kernel oil included lecithin liposome has good scar-fading effect in the soothing scar-fading product.

Description

technical field [0001] The invention belongs to the field of daily chemicals and relates to a liposome, specifically a lecithin liposome embedded with crabapple fruit oil and its application in products for calming and reducing scars. Background technique [0002] Scar, also known as scar, is a general term for the appearance and histopathological changes of normal skin tissue caused by various traumas. It is an inevitable product in the process of human trauma repair. However, the existence of scars will not only affect people's external image, but also sometimes cause various complications, bringing people great physical pain and mental torture, so it is very important to calm down the scars. [0003] Crabapple fruit oil is extracted from the nuts of the crabapple tree in Indonesia and is certified as an organic vegetable oil by ECOCERT. This native vegetable oil is rich in biological activity, contains a variety of fatty acids and fat accompanying substances (resins and ...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/55A61K8/92A61Q19/02
CPCA61K8/14A61K8/553A61K8/922A61Q19/02
Inventor 章苏宁周艳
Owner 上海京樾医疗科技有限公司
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