60 results about "Co delivery" patented technology

The invention provides methods and compositions for local manipulation of regenerative processes via exogenous factor delivery.

The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices.

Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.

The invention belongs to the field of pharmaceutic preparations, and relates to a targeted ligand-PEG (polyethylene glycol)-cholesterol / tocopherol derivative, and a preparation method and an application of the derivative, in particular to an application of the derivative in a composite mechanism mediate tumor targeted drug delivery system. According to the derivative, the preparation method and the application, a drug delivery system consisting of the targeted ligand-PEG-cholesterol / tocopherol derivative with a targeting function, a long circulating function and a pH (power of hydrogen) sensitive function as a functional material, a cation liposome and a drug can simultaneously carry anticancer polypeptide and gene / chemotherapy drugs. According to the system, different drugs are jointly entrapped into the lipid nano drug delivery system and delivered into a targeted cell by utilizing a physicochemical property difference between components or by in-vivo specific targeted recognition, signal conduction blocking and pH triggering PEG chain breaking charge reversion methods, so that a targeted tumor therapeutic effect is improved. According to the derivative, the preparation method and the application, the advantages of the system in directional delivery, co-delivery and the like are proved by in-vivo and in-vitro activity evaluation, the anticancer activity is improved significantly, and definite synergic therapeutic and immunity effects are provided.

The invention discloses a co-delivery nano-carrier of drugs and genes, a preparation method and an application thereof; and particularly relates to a co-delivery nano-carrier TCPL-siRNA-PPX which can carry a chemotherapeutic drug and a genetic drug simultaneously. The drug delivery system is composed of a polymer prodrug carrier TCPL, siRNA and a multifunctional polyanionic polyer PPX through electrostatic adsorption among the components in a self-assembly manner. The co-delivery nano-carrier can achieve targetedly delivery of the drug and the gene to the same tumor cell, release the siRNA at the cytoplasm, silence Bcl-2 protein, promote apotosis and relieve inhibition of the Bcl-2 on lonidamine, and can deliver the chemotherapeutic drug, lonidamine, which is mitochondrion-acted to mitochondria so that the chemotherapeutic drug and the gene can synergistically trigger the apotosis of a mitochondrial pathway and kill tumor cells cooperatively. Through in-vivo and in-vitro activity evaluation, the drug delivery system is proved to be better than drug delivery carriers which deliver single components respectively at the same time, can significantly improve the anti-cancer activity of the drug and the gene and has a definite synergistic treatment effect.

The invention relates to the field of medical technologies, in particular to a lipoic-acid-modified nanometer polypeptide carrier and a preparation method and application thereof.The lipoic-acid-modified nanometer polypeptide carrier is composed of arginine, histidine, lipoic acid and cysteine.A disulfide bond contained in lipoic acid is adopted for cross-linking, a formed polypeptide polymer can be rapidly degraded in cells and will not accumulate in the cells, and arginine and cysteine in polypeptide are in-vivo amino acid and are free of toxic and side effects to the human body.A CCK-8 cell proliferation test shows that the prepared nanometer carrier has low cell toxicity and meanwhile has good capacity of co-delivery of a gene and chemotherapy drugs; the nanometer carrier can specifically enhance the sensitivity of drug-resistant cells to the chemotherapy drugs in breast cancer drug-resistant treatment and promote apoptosis of breast cancer cells, and therefore becomes a targeted, efficient and low-toxicity nanoscale delivery system in breast cancer drug-resistant treatment.

The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome.

The invention provides a cationic polymer-loaded paclitaxel / indocyanine green (ICG) co-delivery micelle and a preparation method thereof. To simultaneously load the chemotherapeutic paclitaxel and the photosensitizer ICG, an amphiphilic degradable cationic nano-micelle MPEG-PCL-PEI is used as a loading medium for the chemotherapeutic paclitaxel; a cationic polymer block is introduced into a polymer MPEG-PCL which forms the nano-micelle, so surface charges of the micelle can be changed; negatively-charged ICG molecules are adsorbed through interaction between positive and negative charges, and sustained release of paclitaxel and ICG is realized; so a novel method is provided for integrated diagnosis and treatment of tumors. According to the invention, the triblock cationic polymer synthesized from an amphiphilic polymer-grafted cationic fragment can simultaneously load the chemotherapeutic paclitaxel and the photosensitizer ICG approved by FDA, so compounding of the chemotherapeutic and fluorescence molecules is realized, and fluorescent imaging of a tumor site as well as target drug delivery for a tumor is complished.

The invention discloses an inner-outer double layer stepwise stimulation response delivery nano-carrier, and a preparation method and an application thereof. The preparation method comprises the following steps: dispersing disulfide bond-modified MCM-41 type mesoporous silicon nano-particles in a solution, coupling the surface of the nano-particles with a cationic polymer, and then coupling the surface of the nano-particles with 2,3-DMMA through the cationic polymer to prepare the meso-porous silicon nano-carrier having double stimulation response. The nano-carrier has the outer-to-inner layerstepwise stimulation response characteristic with the outer layer corresponding to pH stimulation response and the inner layer corresponding to redox reduction stimulation response. Drug molecules can be encapsulated into the meso-pores of the nano-particles, and the cationic polymer can bind genes, so the nano-carrier is suitable for preparing drug delivery carriers, nucleic acid delivery carriers or drug-nucleic acid co-delivery carriers.

The invention discloses an amphiphilic camptothecin polymer prodrug taking phenylboronic acid ester as a connecting unit and a co-delivery micelle system thereof. A polyethylene glycol-polyglutamate camptothecin two-block polymer (mPEG-BC-PGluCPT) is synthesized by taking catechol phenylborate (BC) as a connecting unit, and then a doxorubicin loaded micelle (mPEG-BC@PGluCPT.Dox) of the polymer isconstructed. Aiming at the poor water solubility of camptothecin, a polymer prodrug using camptothecin as a hydrophobic end by modifying 20 sites of hydroxyl groups of camptothecin is synthesized, which can effectively promote the assembly of the two-block polymer into a micelle. The solubility of camptothecin is improved, the stability of a camptothecin lactone ring is increased, and the curativeeffect and bioavailability are improved in order to overcome limitations of clinical treatment of camptothecin. The amphiphilic camptothecin polymer prodrug prepared by the method provided by the invention can be used for constructing a nano drug common delivery system, and has good drug release property, strong cell inhibition rate and good cell phagocytosis.

The invention discloses a polyethylene glycol-aminated poly(glycidyl methacrylate)-poly(diisopropylaminoethanol methacrylate) triblock polycation and a synthetic method thereof, and a dual acid-sensitivity multilayer cation micelle prepared from the triblock polycation and a preparation method thereof. The cation micelle comprises a neutral polyethylene glycol PEG external layer, an aminated poly(glycidyl methacrylate) PAG intermediate layer and a poly(diisopropylaminoethanol methacrylate) PDPA inner layer, wherein the PEG external layer can shield a part of positive charges and improve stability of the micelle, the PAG intermediate layer has positive electricity and can absorb electronegative nucleic acid drugs, and the PDPA inner layer has hydrophobicity and can entrap hydrophobic drugs. Furthermore, the invention also discloses application of the dual acid-sensitivity multilayer cation micelle in synchronous co-delivery of nucleic acid and hydrophobic anticancer drugs, and the dual acid-sensitivity multilayer cation micelle is mainly used for reversion of multidrug resistance of cancer cells or inhibition of cancer cell metastasis.

Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.

Nanoparticles containing an aqueous core containing one or more nucleic acids, such as siRNA, and a shell containing one or more hydrophobic cationic materials, one or more amphiphilic materials, and one or more therapeutic, diagnostic, and / or prophylactic agents are. The hydrophobic cationic material and the hydrophobic portion of the amphiphilic material provide a non-polar polymer matrix for loading non-polar drugs, protect and promoting siRNA molecule retention inside the NP core, and control drug release. The hydrophilic portion of the amphiphilic material can form a corona around the particle which prolongs circulation of the particles in the blood stream and decreases uptake by the RES.

The invention discloses a polyethylene glycol-chitosan-curcumin polymer, drug-loaded nano particles thereof and a preparation method thereof. The polyethylene glycol-chitosan-curcumin polymer is capable of grafting curcumin as a hydrophobic group to a framework material of nanoparticles, helps to form nanoparticles, forms a novel dosage form of curcumin, and acts as a carrier of other hydrophobicanticancer drugs to achieve the purpose of the combined medication. The polyethylene glycol-chitosan-curcumin nanoparticles are the novel dosage form of curcumin, which can be used as the carrier forother hydrophobic anticancer drugs to achieve controlled release of drugs. The nanoparticles have good biocompatibility and long circulation, and escape from the phagocytosis of a reticuloendothelialsystem. can be used as a co-delivery system for delivery of curcumin and other hydrophobic anti-tumor drugs to reach the combined medication, can improve the treatment by regulating different signaling pathways, also helps to minimize the occurrence of multidrug resistance at a large degree, and inhibits tumor growth.

The invention relates to a temperature-sensitive phase-change fatty alcohol mediated amphiphilic drug delivery / controlled release carrier as well as a preparation method and an application thereof, and belongs to the field of nano biological materials. The carrier is prepared by encapsulating one or more hydrophilic / hydrophobic chemotherapy drugs in hollow nanoparticles on the basis of the amphiphilic property of temperature-sensitive phase-change fatty alcohol. The temperature-sensitive phase-change fatty alcohol mediated amphiphilic drug delivery / controlled release carrier provided by the invention is prepared by the following operations: dissolving the chemotherapy drugs in the temperature-sensitive phase-change fatty alcohol under a high-temperature oil bath condition; loading the dissolved chemotherapy drugs in cavities of the hollow nanoparticles under the action of a permeation assisting agent; collecting a drug carrier after centrifugal separation, washing and drying; and grafting tumor-targeted molecules onto the surface of the carrier, so that the tumor-targeted molecule grafted temperature-sensitive phase-change fatty alcohol mediated amphiphilic drug delivery / controlledrelease carrier is prepared. With the application of the drug carrier, co-delivery of various hydrophilic / hydrophobic chemotherapy drugs can be achieved; and the drug carrier, when applied to tumor resistance, can be combined with a thermotherapy action so as to kill and ablate tumor cells or solid tumors.

The invention relates to preparation and application of a gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle of a target SR-BI (Scavenger Receptor-BI). The nanoparticle is a recombinant high density lipoprotein drug-loaded nanoparticle, comprises phospholipid, cholesterol, cholesteryl ester, apolipoprotein, cation lipid, a chemotherapeutic drug, a gene drug and the like, and is prepared by a film dispersion method. The invention aims at preparing the bionic tumor target drug-loaded nanoparticle, the preparation condition is mild, and the cost is low. The invention further provides the application of the gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle. The gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle has the advantages of spherical structure, good encapsulation efficiency, low cytotoxicity, good targeting, high safety, significant in-vitro anti-tumor effect and the like.

The invention discloses a co-delivery system of a photo-responsive chemotherapeutic drug and a preparation method thereof. A prodrug is prepared through covalent linkage of a double branched type photosensitive carrier with o-nitrobenzyl as a structural unit and an antineoplastic drug with different mechanism of action to form the co-delivery system of the photo-responsive chemotherapeutic drug. The co-delivery system of the photo-responsive chemotherapeutic drug has the beneficial effects that the advantages of excellent controllability of exogenous excitation photons and multidrug resistance (MDR) effect of combined chemotherapy capable of effectively inhibiting tumors in tumor therapy are combined; and the controllable release of different drugs is realized by changing parameters of excitation light so as to solve the technical problem of intelligent drug release in the co-delivery systems of traditional drugs; and the co-delivery system can be applied to tumor treatment.

The invention provides application of vitamin E polyethylene glycol succinate (TPGS) and derivatives thereof in preparation of a hydrogel nanoparticle preparation of prodrug of a hydrophilic medicine. The application disclosed by the invention has the following technical effects: (1) the prepared preparation is a nano-scale biological preparation; (2) sustained release of the hydrophilic medicine is realized; (3) the biocompatibility of the hydrogel nanoparticle is enhanced by virtue of the vitamin E polyethylene glycol succinate; and (4) TPGS and derivatives thereof are applicable to co-delivery of multiple medicines so as to achieve a synergistic effect.

The invention discloses albumin nanoparticles realizing co-delivery of an antitumor drug and an MRI (magnetic resonance imaging) contrast medium and a preparation method of the albumin nanoparticles and further provides an albumin nanoparticle vector containing the MRI contrast medium, and drug loading is realized through electrostatic adsorption and coordination between the drug and the vector as well as crosslinking of amino acid residues of the vector. The invention further discloses an optimal preparation technology of the albumin nanoparticles realizing co-delivery of the antitumor drug and the MRI contrast medium and a function of the albumin nanoparticles in diagnosis and treatment combination of tumors. According to the albumin nanoparticles realizing co-delivery of the antitumor drug and the MRI contrast medium, the drug uptake ratio of cells can be increased, and drug efflux caused by drug-resistant cells is reduced, so that drug resistance is reversed, and efficient delivery of the drug is realized; the albumin nanoparticles realizing co-delivery of the antitumor drug and the MRI contrast medium have excellent T1 weighted imaging capability and an effective means is provided for the diagnosis and treatment combination of the tumors.

A method for introducing a precursor vapor to a process chamber configured for forming a thin film on a substrate is described. The method includes transporting a process gas containing metal precursor vapor and a CO delivery gas to a process chamber, and introducing a CO saturation gas to the precursor vapor in the process chamber and optionally adjusting the spatial distribution of the CO saturation gas addition in order to affect improvements to the properties of the deposited film.

The invention belongs to the technical field of cosmetics and provides a compound polypeptide nano vesicle and a preparation method and application thereof. The compound polypeptide nano vesicle comprises, by mass, 0.01-1% of hair growth promoting peptide, 0.01%-1% of hair root strengthening peptide, 0.01-1% of anti-inflammation antibacterial peptide, 0.01-1% of antioxidant active peptide, 0.1%-10% of a 5 alpha-reductase inhibitor, 0.5%-10% of a lipoid wall material, 0.1%-20% of an emulsifying agent, 0.1%-5% of cholesterol and 10-45% of polyalcohol. The compound polypeptide nano vesicle has advantages that the hair root strengthening peptide, the hair growth promoting peptide, the anti-inflammation antibacterial peptide, the antioxidant active peptide and the plant-derived 5 alpha-reductase inhibitor are jointly loaded in a same nano carrier, multi-target-point transdermal co-delivery of anti-hair-loss active components deep into hair follicles can be realized, synergistic effects areachieved, and dual efficacies including hair loss preventing and hair growth promoting are realized.

The invention relates to the technical field of cold chain transportation and more particularly relates to a goods shelf moving type vehicle-mounted multi-temperature automatic co-delivery refrigerating cabinet. According to the technical scheme, the goods shelf moving type vehicle-mounted multi-temperature automatic co-delivery refrigerating cabinet is characterized by comprising a cabinet body with one side opened; two separation bars are vertically arranged at the opening part of the cabinet body, and an inner cavity of the cabinet body is divided into two first containing grooves and a second containing groove through the two separation bars; the second containing groove is located between the two first containing grooves, and a first guide rail groove is formed in the middle portion of the groove bottom of each first containing groove in the length direction; second guide rail grooves are formed in the two sides of the bottom face of the second containing groove in the length direction; outer goods shelves are connected to the first guide rail grooves in a sliding manner, and the bottom walls of the outer goods shelves are connected with bearing wheels which extend out of theouter sides of the first containing grooves; and a movable goods shelf mechanism is connected to the second guide rail grooves in a sliding manner, and heat insulation partition plates are arranged between the outer goods shelves and the movable goods shelf mechanism. The goods shelf moving type vehicle-mounted multi-temperature automatic co-delivery refrigerating cabinet has the beneficial effects that during multi-temperature-area goods storing and goods delivering, heat insulation effectiveness is good, storage integration is achieved, and automatic goods taking is achieved.

The invention relates to methods and devices for co-delivery of liquid and powdered hemostats and sealants. The present invention is directed to an integrated delivery device that is operable with onehand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using suchintegrated devices.

A injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (10) containing a primary reservoir containing a first medicament (1) and that has a secondary reservoir containing a second medicament (2) where the drug delivery device (10) has only one dose setter (12) for the primary reservoir and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface.

The invention relates to new anti-wrinkle and anti-aging nanoformulations, composed of non-toxic mesoporous silica nanoparticles, natural plant extracts (as the case may be: pomegranate oil, fennel oil, rosemary oil, chamomile oil, jojoba oil, rosehip oil), biological active agents (acetyl hexapeptide-8, aspartic acid), vitamins and others. Additionally, the present invention relates a new method for preparing the nanoformulations by co-encapsulating its active agents within a multilayer nanocarrier, thereby, enhancing their delivery through the skin barrier and their controlled accumulation at the desired site.In certain embodiments, the active molecules are co-incorporated into an inner polymeric shell (silica derivatives) and onto its surface, followed by, the protection of an outer layer of chitosan-TAT (GRKKRRQRRRPQ). The active ingredients are crossed through the skin barrier using the disclosed delivery system to promote cell growth, skin rejuvenation and wrinkle removal.

The invention relates to a mannose modified co-loaded antigen and a double immuno-agonist phospholipid hybrid polymer vesicle as well as a preparation method and application thereof. A vaccine carriertakes an amphiphilic triblock copolymer as material, OVA is loaded in the hydrophilic inner cavity, IMQ is loaded in the hydrophobic membrane layer, DOTAP cationic layer is fitted with MPLA, and cationic lipid outer layer adsorbs outer layer OVA; phospholipid with reactive group is introduced to pass the targeted mannose ligand through covalently linked to the PEG-active distal end of the polymer-loaded vesicle surface, integrating the functions of active targeting of tumors, co-delivery of antigens and adjuvants and the like; the vesicle has the characteristics of small particle size, good dispersion, high antigen loading and good biocompatibility, etc., which can promote antigen uptake, DC activation and maturation, antigen cross-presentation, antigenic lymph node migration, lymphocyteactivation, effector T cell immune response, CD8<+> T and CD4<+> T cell responses, and memory T cells immune response.

The invention belongs to the field of pharmaceutical preparations and relates to a drug delivery system for targeting co-delivery of a photosensitizer and a chemotherapeutic drug. According to the drug delivery system, a nanometer preparation is prepared from vitamin E polyethylene glycol succinate-L-polylactic acid as a raw material, a chemotherapeutic drug adriamycin is wrapped in a hydrophobic inner core of the nanometer preparation, simultaneously, a photosensitizer chlorin e6 is connected to vitamin E polyethylene glycol succinate (TPGS) through a covalent bond, then the compound is inserted into a shell structure of the nanometer preparation so that efficient and stable coating of the chemotherapeutic drug and the photosensitizer is realized, and a polypeptide tLyp-1 having a targeting function modifies the surface of the nanometer preparation through a covalent bond so that nanometer preparation vascular permeability and tumor penetrability are promoted. Results of in-vitro and in-vivo experiments show that the drug delivery system is used for treatment on tumors resisting multiple drugs, has the characteristics of good targeting ability, high efficiency and low toxicity, and has a clinical application prospect.