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35 results about "Double stimulation" patented technology
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Double-stimulation ultrasonic elliptical vibration processing device
InactiveCN103586192ALarge magnetostrictive strainIncrease output powerMechanical vibrations separationSonificationTransducer
Provided is a double-stimulation ultrasonic elliptical vibration processing device. A giant magnetostrictive material is adopted to serve as a drive element, two sets of giant magnetostrictive transducers are arranged in parallel, large-area one-way water-cooling systems are arranged in the transducers, and flexible hinge connection is adopted at vibration output ends. The device has the advantages of being high in output power, loading capacity and energy conversion efficiency, wide in bandwidth, compact and reasonable in structure and the like, and can be widely applied to various ultrasonic elliptical vibration processing operating conditions.
Owner:HUAZHONG UNIV OF SCI & TECH
Inner-outer double layer stepwise stimulation response delivery nano-carrier, and preparation method and application thereof
InactiveCN107648614AGood water dispersibilityGood biocompatibilityOrganic active ingredientsGenetic material ingredientsDouble stimulationDisulfide bond
The invention discloses an inner-outer double layer stepwise stimulation response delivery nano-carrier, and a preparation method and an application thereof. The preparation method comprises the following steps: dispersing disulfide bond-modified MCM-41 type mesoporous silicon nano-particles in a solution, coupling the surface of the nano-particles with a cationic polymer, and then coupling the surface of the nano-particles with 2,3-DMMA through the cationic polymer to prepare the meso-porous silicon nano-carrier having double stimulation response. The nano-carrier has the outer-to-inner layerstepwise stimulation response characteristic with the outer layer corresponding to pH stimulation response and the inner layer corresponding to redox reduction stimulation response. Drug molecules can be encapsulated into the meso-pores of the nano-particles, and the cationic polymer can bind genes, so the nano-carrier is suitable for preparing drug delivery carriers, nucleic acid delivery carriers or drug-nucleic acid co-delivery carriers.
Owner:GUANGDONG MEDICAL UNIV
Acid/base double stimulation responsive nanometer container and preparation method thereof
InactiveCN106337187ASimple structureEasy to manufactureMaterial nanotechnologyMicrosphereSilicon dioxide
The invention discloses an acid / base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid / base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.
Owner:NANJING UNIV OF SCI & TECH
Artificial electronic cochlea and method for processing speech with double stimulation rates
ActiveCN101773429AImprove speech recognition performanceSolve the problem of missing low-amplitude envelope informationEar treatmentSpeech ProcessorElectrical impulse
The invention discloses an artificial electronic cochlea, a speech processor and a method for processing a speech with double stimulation rates. The speed processor and the method are applied to the artificial electronic cochlea, and the method comprises the following steps of: firstly, performing preprocessing, band-pass filtering, half-wave rectification and low-pass filtering on speech signalsto acquire the envelope amplitude of each channel, and adjusting the current amplitude to a working amplitude range; secondly, selecting a plurality of channels of which the envelope amplitudes are more than or equal to a threshold value to form a first part (high-amplitude) channel, and performing pulse sequence modulation with a first (high) stimulation rate on the first part channel; selectinga plurality of channels of which the envelop amplitudes are smaller than the threshold value to form a second part (low-amplitude) channel, and performing pulse sequence modulation with a second (low) stimulation rate on the second part channel; and adopting electronic pulse sequences of the first and second part channels after modulation to stimulate corresponding stimulating electrodes. The artificial electronic cochlea, the speech processor and the method realize the aim of transmitting information on the envelope amplitudes of all the channels to an artificial electronic cochlea patient, and effectively improve the speech recognition effect of the artificial electronic cochlea.
Owner:ZHEJIANG NUROTRON BIOTECH
Preparation method and applications of mesoporous calcium carbonate medicinal composition modified by hyaluronic acid
ActiveCN106362172ASimple preparation processReliable methodInorganic non-active ingredientsEchographic/ultrasound-imaging preparationsSocial benefitsControlled release
The invention relates to a preparation method and applications of a mesoporous calcium carbonate medicinal composition modified by hyaluronic acid, for effectively simultaneously realizing targeting, controlled release and ultrasonic therapy and ultrasonic imaging combination, and further realizing diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation method comprises the following steps: modifying hyaluronic acid on aminated calcium carbonate obtained by reacting mesoporous calcium carbonate and 3-aminopropyl triethoxysilane, and then loading a micromolecular sonosensitizer, thus obtaining the mesoporous calcium carbonate medicinal composition modified by hyaluronic acid. The preparation method has the advantages that a preparation process is simple, a method is stable and reliable, the production cost is low, and the prepared mesoporous calcium carbonate modified by hyaluronic acid and the medicinal composition of mesoporous calcium carbonate simultaneously have the efficacies of tumor targeting, in vitro and in vivo double-stimulation (in acid environment and under high-intensity focused ultrasonic condition) sensitive medicine release, sonodynamic therapy and ultrasonic imaging combined diagnosis and treatment integration, belong to an innovation in tumor treatment medicines, and have enormous economic and social benefits.
Owner:ZHENGZHOU UNIV
Preparation method and application of photothermal double stimulation response hydrogel containing alpha-cyclodextrin
ActiveCN110423307AChange water solubilityHigh drug loadDrug photocleavageAerosol deliveryWater bathsDouble stimulation
The invention belongs to the technical field of environmental functional material preparation, and relates to a preparation method and application of a photothermal double stimulation response hydrogel containing alpha-cyclodextrin. The method comprises the following steps: firstly preparing alpha-cyclodextrin ester and acrylamido azobenzene, adding the alpha-cyclodextrin ester, the acrylamido azobenzene, methylene bisacrylamide and isopropylacrylamide into a dimethyl sulfoxide solution, and performing ultrasonic shaking to obtain a mixed solution B; adding 2,2'-azobis(2,4-dimethyl)valeronitrile into a dimethyl sulfoxide solution to obtain a mixed liquid D; and finally, adding the mixed liquid D into the mixed liquid B, after mixing is completed, performing a reaction in a water bath to obtain the photothermal double stimulation response hydrogel. According to the method provided by the invention, the cyclodextrin and the photo and temperature structure response units are introduced into the hydrogel prepared by the method, so that the hydrogel can load a large amount of drug molecules, and when an external temperature and an illumination wavelength are changed, the hydrogel can have responsive change of adjusting a release speed of the drug molecules in time; and at the same time, the method is simple and convenient to operate, and the prepared hydrogel is safe and environmentally friendly and has good stability.
Owner:JIANGSU UNIV
Double-stimulation response drug based on EGCG and metal ions and preparation method
InactiveCN107095861AKeep aliveMild conditionsOrganic active ingredientsPeptide/protein ingredientsMetal ions in aqueous solutionMorpholine
The invention discloses double-stimulation response drug based on EGCG and metal ions and a preparation method. The preparation method comprises the following steps: (1) adding water-soluble drug in a dimethyl imidazole aqueous solution, pouring the mixture in water which contains polyvinylpyrrolidone and zinc nitrate, stirring and centrifuging, and washing with deionized water to obtain zeolimidazole skeleton-8 particles which contains the water-soluble drug; and (2) dispersing the zeolimidazole skeleton-8 particles which contains the water-soluble drug in deionized water, adding an epigallocatechin gallate aqueous solution, vibrating to enable the components to be dispersed uniformly, adding a metal salt aqueous solution, vibrating to enable the components to be dispersed uniformly, adding a 3-(N-morpholine) sodium proparesulfonic acid salt buffer solution, vibrating, centrifuging, washing with water, washing with an EDTA aqueous solution, and washing with deionized water to obtain the double-stimulation response drug based on EGCG and metal ions. Preparation conditions are gentle, activity of the water-soluble drug and use safety of a carrier are guaranteed, raw materials are low in cost and easy to obtain, and the preparation process is simple.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Double stimulation
ActiveUS9782320B2Shorten the timeReduce stimulation timePhysical therapies and activitiesPneumatic massageNasal cavityVibration treatment
A method of vibration treatment in at least one nasal cavity of a human subject is provided. The method includes the steps of: inserting a first stimulation member in a first nasal cavity; inserting a second stimulation member in a second nasal cavity; securing the first and second stimulation members such that the stimulation members are in fixed positions within the nasal cavities prior to vibration stimulation; arranging each of the first and second stimulation members to abut against tissue within each of the first and second nasal cavities at a first and second pressure; and imparting vibrations to tissue in at least one of the first and second nasal cavities via at least one of the first and second stimulation members.
Owner:CHORDATE MEDICAL AB
Double-stimulation expanding gel particle for preventing gas channeling in process of carbon dioxide oil displacement and preparation method of double-stimulation expanding gel particle
ActiveCN108659163AAlleviate or eliminate heat-induced dehydration problemsImprove the blocking effectDrilling compositionTemperature responseThermal stimulation
The invention discloses a preparation method of a double-stimulation expanding gel particle for preventing gas channeling in the process of carbon dioxide oil displacement. The method includes: 1), dissolving an acrylamide monomer into water to form a solution, adding a crosslinking agent, a temperature response monomer methacrylic acid N, an N-dimethylaminoethyl ester monomer and carbon dioxide response monomer (2-(methacrylenyl oxide) ethyl) dimethyl-(3-sulfonic acid propyl) ammonium hydroxide to the solution with even stirring to form a mixed monomer solution polymerization system, and feeding nitrogen to the polymerization system to remove dissolved oxygen in the system; 2), mixing the mixed monomer with an initiator solution for polymerization reaction. The gel particle continuous expands under CO2 and thermal stimulation, secondary expansion of the gel particle under the acidic environment is achieved, and long-time blocking function can be played.
Owner:SICHUAN UNIV +1
Triple stimulation responsive core cross-linked polymeric micelle as well as preparation method and application thereof
ActiveCN109320636ASmall particle size distribution rangeImprove stabilityPharmaceutical non-active ingredientsEmulsion deliveryCross-linkSodium ascorbate
The invention discloses a triple stimulation responsive core cross-linked polymeric micelle as well as a preparation method and application thereof. The structural formula of the micelle is as shown in the description, wherein x is an integer of 30 to 70, y is an integer of 20 to 50 and the value of x1 is 20% to 50% of that of the x. According to the preparation method, an amphipathic diblock polymer is obtained through atom transfer radical polymerization (ATRP), and is modified by utilizing an azidation reaction; an azidation product can self-assemble to form a core-shell structure in water;and the light, oxidation and reduction triple stimulation responsive core cross-linked polymeric micelle is obtained through click chemistry under the action of a cross-linking agent with redox sensitiveness, anhydrous cupric sulfate and sodium ascorbate. The triple stimulation responsive core cross-linked polymeric micelle provided by the invention has favorable in-vitro stability, can be used for realizing a high-efficiency controlled release behavior of a hydrophobic drug under the double stimulation of light and oxidation or reduction, and has favorable application prospects in the aspects of the delivery and the controlled release of a hydrophobic anti-cancer drug.
Owner:SHAANXI NORMAL UNIV
Silane coupling agent with double stimulation response and preparation method and application thereof
InactiveCN110204569ARapid change in surface wettabilityImprove hydrophobicityGroup 4/14 element organic compoundsTriethoxysilaneUltraviolet lights
The invention discloses a silane coupling agent with double stimulation response and a preparation method and application thereof. The preparation method comprises the following steps that 3-hydroxyl,5-dicyclopentadienyl alkoxy methyl benzoate and bromoalkoxy azobenzene generate 3-dicyclopentadienyl alkoxy,5-azobenzene alkoxy methyl benzoate under base catalysis, and then the 3-dicyclopentadienylalkoxy,5-azobenzene alkoxy methyl benzoate is reduced to a 3-dicyclopentadienyl alkoxy,5-azobenzene alkoxy benzyl alcohol end capping agent; under the protection of nitrogen, the 3-dicyclopentadienylalkoxy,5-azobenzene alkoxy benzyl alcohol, propyl isocyanate triethoxysilane and a catalyst organic tin are added into methylbenzene, the temperature is increased to 80-110 DEG C, and a reaction is carried out to obtain the dicyclopentadienyl azobenzene silane coupling agent. The silane coupling agent can be used for modifying the surface of glass, and the modified glass has the characteristic ofbeing able to be oxidized by ultraviolet light for double stimulation response to change the hydrophilicity of the surface.
Owner:SOUTH CHINA UNIV OF TECH
Composite multi-effect facial mask liquid
InactiveCN108653054ARelieve tightnessRelieve fatigueCosmetic preparationsToilet preparationsAminoethyl methacrylateDual response
The invention belongs to the technical field of beauty and skin care, and particularly relates to facial mask liquid. According to the facial mask liquid, methyl methacrylate, N,N-dimethyl-2-aminoethyl methacrylate and the like are taken as raw materials to prepare composite microgel, a primary amine structure is contained and can bring CO2 stimulation response, the components in auxiliary materials can also introduce a temperature-sensitive effect, the primary amine structure and the auxiliary materials are combined, so that the temperature and CO2 double-stimulation response functions are achieved, a cooling enhancer in a facial mask liquid system acts on a face when a facial mask is used, so that the face temperature is lowered, nervous-humoral regulation can be caused due to the relative cold condition to increase thyroid secretion, so that the dual response of the composite microgel is just stimulated, the effect of massaging the face is achieved, in addition, the release and absorption of other nutrients are also improved in the heat transfer process, the skin compactness and fatigue can be effectively relieved, and a good environment is provided to achieve the absorption ofother nutrient substances and water replenishment function; and the problem that an existing facial mask is single in using effect, and people feel uncomfortable when the skin of the face is moisturized can be solved.
Owner:王建东
Preparation method of double-stimulation response type polyurethane micelle
ActiveCN110551273AImprove featuresImprove the environmentBiocompatibility TestingAtom-transfer radical-polymerization
The invention discloses a preparation method of a double-stimulation response type polyurethane micelle. The preparation method comprises the following steps: preparation of an initiator, preparationof an end capping agent, preparation of a vanillin acetal compound, preparation of end-capped polyurethane and preparation of a polyurethane micelle solution. The end-capped pH and temperature double-response type multi-block polyurethane micelle is successfully prepared by combination of technologies of preparing the hydrophilic temperature-sensitive end-capping agent by atom transfer radical polymerization, introducing amphiphilic segments into a polyurethane chain to form micelles and the like. The prepared polyurethane micelle has excellent biocompatibility and biodegradability, and meanwhile has a pH response characteristic and a temperature sensitivity characteristic.
Owner:QILU UNIV OF TECH
Methane locking alarm
The invention provides a methane locking alarm which can effectively detect methane concentration and personnel information in a firing area. The methane locking alarm comprises a microcontroller which has operation and treatment actions and is characterized in that an input port of the microcontroller is connected with a methane sensor and a human body sensor, an output port of the microcontroller is connected with an LED digital display, and a control port of the microcontroller is connected with a recording and playing chip; the recording and playing chip is connected with an audible and visual alarm via an audio power amplifier. The methane closing alarm is provided with the methane sensor and the human body sensor, so that the detonation of a detonating cap under the condition that working personnel do not evacuate or the concentration of methane gas exceeds standard; the recording and playing chip and the audible and visual alarm are also arranged, the double stimulation of audible signals and visual signals are adopted to warn the working personnel in a burst area.
Owner:山东隆泰安防科技有限公司
Dual-purpose illuminating lamp
InactiveCN106609958AGood wake up effectElectric circuit arrangementsLighting elementsEngineeringDual purpose
The invention discloses a dual-purpose illuminating lamp which comprises a lamp body, wherein a buzzer is arranged on the lamp body; two switches, namely a first switch and a second switch, are arranged on a wall body, and connected with lamp body wires correspondingly; the on-off of the lamp body is independently controlled by the first switch; the second switch is in series control with the lamp body and the buzzer; and a timer is arranged on the second switch, and connected in series into the buzzer and a lamp body control loop. The dual-purpose illuminating lamp disclosed by the invention not only can be independently used as a lamp for providing light, but also is equipped with an alarm clock which can be under the fixed-time control; a fixed time can be set as required, and the buzzer makes a sound when the set time point is reached; meanwhile, the lamp body is turned on, thereby achieving double stimulation from the senses of hearing and eyesight as well as a very good wake-up effect; and after a user gets up, the lamp body and the buzzer can be turned off through the second switch.
Owner:吴建平
Folic acid receptor-mediated in-tumor environment-sensitive doxorubicin albumin nanoparticle and preparation method
ActiveCN109453389AImprove targetingIncrease concentrationOrganic active ingredientsPharmaceutical non-active ingredientsSpherical shapedFolate targeting
The invention discloses a folic acid receptor-mediated in-tumor environment-sensitive doxorubicin albumin nanoparticle and a preparation method. An amino group and a carboxyl group are condensed and subjected to acylation reaction, and folic acid is linked to albumin; after a one-pot amide reaction, histamine is mixed with a folic acid-albumin solution to obtain a folic acid-targeted and pH-sensitive folic acid-albumin-histamine modifier; glutathione is used for opening a disulfide bond in the folic acid-albumin-histamine, and mixed with doxorubicin at alkaline pH to achieve spontaneous cross-linking of the intermolecular disulfide bond and to obtain the folic acid receptor-mediated pH-and-glutathione-sensitive albumin doxorubicin nanoparticle. The nanoparticle provided by the invention has an approximate spherical shape and strong uniformity, the particle size of about 70 nm, a small dispersion coefficient, good stability, and high drug loading and embedding rate of doxorubicin; underthe double stimulation of pH and glutathione, a drug can be quickly released, and the important application value is achieved in targeted drug delivery to tumors.
Owner:SUZHOU UNIV
Rat model with symptom of cold fluid retention in lung of bronchial asthma and construction method of rat model
InactiveCN107744589AModeling method is simpleCompounds screening/testingBacterial antigen ingredientsAntigenAbdominal cavity
The invention belongs to the field of biological medicine, and in particular relates to a rat model with the symptom of cold fluid retention in lung of bronchial asthma and a construction method of the rat model. The construction method comprises the following steps: (1) injecting antigen liquid into the abdominal cavities of rats so as to sensitize the rats; when asthma is excited after two weeks, keeping the rats in various groups in a semi-closed rat cage, and exciting the rats through aerosol inhalation of egg albumin normal saline; and (2) in an exciting period, applying double-stimulation, namely chilling stimulation and tiring stimulation, to the rats, so that the rat model with the symptom of cold fluid retention in lung of bronchial asthma is obtained.
Owner:SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
Light-magnetism dual stimulus-responsive surfactant
InactiveCN105921068AExpand the adjustment rangeExpand the scope of useOrganic chemistryTransportation and packagingSURFACTANT BLENDDouble stimulation
The invention discloses a light-magnetism dual stimulus-responsive surfactant. The surface tension and the contact angle of the surfactant change under the action of light and a magnetic field, in other words, the surfactant has dual stimulus responsibility.
Owner:JIANGNAN UNIV
A kind of acid/alkali dual stimulus responsive nano container and its preparation method
InactiveCN106337187BSimple structureEasy to manufactureMaterial nanotechnologyPharmaceutical non-active ingredientsMicrosphereResponse type
The invention discloses an acid / base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid / base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.
Owner:NANJING UNIV OF SCI & TECH
Methane locking alarm
The invention provides a methane locking alarm which can effectively detect methane concentration and personnel information in a firing area. The methane locking alarm comprises a microcontroller which has operation and treatment actions and is characterized in that an input port of the microcontroller is connected with a methane sensor and a human body sensor, an output port of the microcontroller is connected with an LED digital display, and a control port of the microcontroller is connected with a recording and playing chip; the recording and playing chip is connected with an audible and visual alarm via an audio power amplifier. The methane closing alarm is provided with the methane sensor and the human body sensor, so that the detonation of a detonating cap under the condition that working personnel do not evacuate or the concentration of methane gas exceeds standard; the recording and playing chip and the audible and visual alarm are also arranged, the double stimulation of audible signals and visual signals are adopted to warn the working personnel in a burst area.
Owner:山东隆泰安防科技有限公司
Exercise device for promoting brain development and repairing brain damage and deploying method thereof
PendingCN109602536AIncrease ratingsIncrease vitalityRoller massageTherapeutic coolingBrain developmentNervous system
The invention provides an exercise device for promoting brain development and repairing brain damage and a deploying method thereof. The device comprises a handle bracket, a rotating shaft, a drum-shaped container and an injection port; the rotating shaft passes through the shaft hole of the drum-shaped container and is in clearance fit with the handle bracket; and the drum-shaped container is provided with a groove and the injection port, and the injection port is sealed by a cover. Besides, the shaft holes of one or two or more drum-shaped containers is strung together on the rotating shaft;or the drum-shaped container is divided along the axial direction into two or more semi-cylindrical containers, one or two or more semi-cylindrical containers are strung together on the rotating shaft. Materials at various temperatures, especially a liquid or ice at various temperatures, are injected into the drum-shaped container. The device is reasonable in structure, easy to manufacture, safeto use and obvious in effects. The drum-shaped container with various temperatures rolls and stimulates the receptors on the skin, so that the neurons of the brain can simultaneously obtain double stimulation exercise of temperature sensation and touch pressure so as to promote the healthy development of nervous system and brain tissues and the repairing of brain damage.
Owner:刘小刚
A kind of method of quick spawning of Scallop mussels
ActiveCN105850801BIncrease egg productionIncrease spawn rateClimate change adaptationPisciculture and aquariaOysterDouble stimulation
Owner:OCEAN UNIV OF CHINA
A method for preparing dual stimuli-responsive surfaces by secondary photopolymerization
The invention discloses a method for preparing double-stimulation responsive surface through secondary photopolymerization, relating to the field of grafting and modification of various base material surfaces. The method comprises the following steps: I, grafting pH responsive compound onto the surface by adopting a cracking type photoinitiator, wherein the pH responsive compound grafted onto the surface can be used as a hydrogen donor and a co-initiator of the next step reaction; and II, performing photopolymerization reaction on the basis by adopting a hydrogen abstracting type initiator, and grafting the double bond-modified photoresponse compound. The method not only has the advantage that the photopolymerization is efficient, energy-saving, economical, environment-friendly, and the like, but also the compound is difficult to drop after being grafted onto the surface through a covalent bond manner. The prepared intelligent surface has good photoresponsiveness, pH responsiveness, and the swelling property and wettability of the surface polymer can be reversibly controlled. The surface has potential application on the aspects of surface molecule switches, surface controlled release and ion adsorption due to good controllable wettability and mechanical effect.
Owner:BEIJING UNIV OF CHEM TECH
Acoustic-electric dual stimulation system and method for ear vagus nerves
The invention discloses an ear vagus nerve acoustoelectric dual stimulation system and method, and relates to the technical field of nerve stimulation medical treatment. The objective of the invention is to solve the technical problems of limited autonomic nerve regulation effect, insufficient cardiovascular disease prevention and treatment efficiency, easy generation of nerve adaptation due to long-term stimulation, poor regulation and control precision and the like in the existing ear vagus nerve single electrical stimulation mode. The system comprises an electrical stimulation module, a sound stimulation module, a control module, an electrode, a sound stimulation probe, a power supply module and a parameter input module, the control module cooperatively regulates and controls all the modules, and the electrodes and the sound stimulation probe output electrical stimulation and sound stimulation respectively. According to the method, acoustic-electric dual synergistic stimulation of the ear vagus nerves is realized by cooperatively regulating and controlling stimulation parameters. The acousto-electric synergistic interaction is utilized, the autonomic nerve regulation and control ability is enhanced, the physiological index regulation precision is improved, related cardiovascular diseases are effectively prevented and treated, the advantages of being high in safety, wide in adaptability, stable in regulation, convenient and fast to operate and capable of being used for a long time are achieved, and the method can be applied to clinical prevention and treatment, rehabilitation treatment and family health management scenes.
Owner:KUNMING YANAN HOSPITAL (KUNMING CADRE NURSING HOME)
Preparation method and application of mesoporous calcium carbonate pharmaceutical composition modified by hyaluronic acid
ActiveCN106362172BRealize sensitive drug release in vivo and in vitroSimple structureInorganic non-active ingredientsEchographic/ultrasound-imaging preparationsSocial benefitsControlled release
The invention relates to a preparation method and applications of a mesoporous calcium carbonate medicinal composition modified by hyaluronic acid, for effectively simultaneously realizing targeting, controlled release and ultrasonic therapy and ultrasonic imaging combination, and further realizing diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation method comprises the following steps: modifying hyaluronic acid on aminated calcium carbonate obtained by reacting mesoporous calcium carbonate and 3-aminopropyl triethoxysilane, and then loading a micromolecular sonosensitizer, thus obtaining the mesoporous calcium carbonate medicinal composition modified by hyaluronic acid. The preparation method has the advantages that a preparation process is simple, a method is stable and reliable, the production cost is low, and the prepared mesoporous calcium carbonate modified by hyaluronic acid and the medicinal composition of mesoporous calcium carbonate simultaneously have the efficacies of tumor targeting, in vitro and in vivo double-stimulation (in acid environment and under high-intensity focused ultrasonic condition) sensitive medicine release, sonodynamic therapy and ultrasonic imaging combined diagnosis and treatment integration, belong to an innovation in tumor treatment medicines, and have enormous economic and social benefits.
Owner:ZHENGZHOU UNIV
Artificial electronic cochlea and method for processing speech with double stimulation rates
ActiveCN101773429BImprove speech recognition performanceSolve the problem of missing low-amplitude envelope informationEar treatmentSpeech ProcessorPulse sequence
The invention discloses an artificial electronic cochlea, a speech processor and a method for processing a speech with double stimulation rates. The speed processor and the method are applied to the artificial electronic cochlea, and the method comprises the following steps of: firstly, performing preprocessing, band-pass filtering, half-wave rectification and low-pass filtering on speech signalsto acquire the envelope amplitude of each channel, and adjusting the current amplitude to a working amplitude range; secondly, selecting a plurality of channels of which the envelope amplitudes are more than or equal to a threshold value to form a first part (high-amplitude) channel, and performing pulse sequence modulation with a first (high) stimulation rate on the first part channel; selectinga plurality of channels of which the envelop amplitudes are smaller than the threshold value to form a second part (low-amplitude) channel, and performing pulse sequence modulation with a second (low) stimulation rate on the second part channel; and adopting electronic pulse sequences of the first and second part channels after modulation to stimulate corresponding stimulating electrodes. The artificial electronic cochlea, the speech processor and the method realize the aim of transmitting information on the envelope amplitudes of all the channels to an artificial electronic cochlea patient, and effectively improve the speech recognition effect of the artificial electronic cochlea.
Owner:ZHEJIANG NUROTRON BIOTECH
Dual-stimulation swelling gel particles used in carbon dioxide flooding process to prevent gas channeling and preparation method thereof
ActiveCN108659163BAlleviate or eliminate heat-induced dehydration problemsImprove the blocking effectDrilling compositionTemperature responseThermal stimulation
The invention discloses a preparation method of a double-stimulation expanding gel particle for preventing gas channeling in the process of carbon dioxide oil displacement. The method includes: 1), dissolving an acrylamide monomer into water to form a solution, adding a crosslinking agent, a temperature response monomer methacrylic acid N, an N-dimethylaminoethyl ester monomer and carbon dioxide response monomer (2-(methacrylenyl oxide) ethyl) dimethyl-(3-sulfonic acid propyl) ammonium hydroxide to the solution with even stirring to form a mixed monomer solution polymerization system, and feeding nitrogen to the polymerization system to remove dissolved oxygen in the system; 2), mixing the mixed monomer with an initiator solution for polymerization reaction. The gel particle continuous expands under CO2 and thermal stimulation, secondary expansion of the gel particle under the acidic environment is achieved, and long-time blocking function can be played.
Owner:SICHUAN UNIV +1
A dual excitation ultrasonic elliptical vibration machining device
InactiveCN103586192BLarge magnetostrictive strainIncrease output powerMechanical vibrations separationTransducerEngineering
Provided is a double-stimulation ultrasonic elliptical vibration processing device. A giant magnetostrictive material is adopted to serve as a drive element, two sets of giant magnetostrictive transducers are arranged in parallel, large-area one-way water-cooling systems are arranged in the transducers, and flexible hinge connection is adopted at vibration output ends. The device has the advantages of being high in output power, loading capacity and energy conversion efficiency, wide in bandwidth, compact and reasonable in structure and the like, and can be widely applied to various ultrasonic elliptical vibration processing operating conditions.
Owner:HUAZHONG UNIV OF SCI & TECH
An anorectal double stimulating electrode device
ActiveCN103989468BEasy accessReflect sensory functionDiagnostic recording/measuringSensorsObstetricsMotor control
The invention provides an electrode device for simulating the anal canal and the rectum. The electrode device for simulating the anal canal and the rectum comprises a rubber balloon used for being placed in the rectum of the human body, the surface of the rubber balloon is provided with four electrodes, a rectum pressure sensor is arranged besides each electrode, the rear end of the rubber balloon is provided with a cylindrical sponge body which corresponds to the anal canal position of the human body and is used for fixing and supporting, the cylindrical sponge body is provided with one or more ring-shaped electrodes, a corresponding anal canal pressure sensor is arranged besides each ring-shaped electrode, a supporting guide tube is arranged inside the rubber balloon and the cylindrical sponge body in a penetrating mode, and a ventilating tube for inflating and deflating of the balloon is arranged inside the supporting guide tube. Each electrode is connected with a motor control wirer, each rectum pressure sensor is connected with a signal transmitting wire, a ring-shaped electrode control wire is led out of each ring-shaped electrode, a signal transmitting wire is led out of each anal canal pressure sensor, and all the control wires and the transmitting wires form a wiring harness, and the wiring harness is led out of the supporting guide tube.
Owner:NANJING HOSPITAL OF T C M
A kind of high-strength cellulose-based nanocomposite temperature, pH dual stimulus responsive gel and preparation method thereof
InactiveCN105440296BGuaranteed biocompatibilityGuaranteed surface propertiesFilament/thread formingMonocomponent synthetic polymer artificial filamentCross-linkCellulose
The invention relates to a preparation method of a high-strength cellulose-based nanocomposite temperature-pH dual-stimuli-responsive gel. The gel uses POSS cross-linked responsive polymer nanofibers obtained by electrospinning as a fiber reinforcement, which is introduced into the dissolved cellulose solution, and a composite gel is formed by cross-linking the cellulose and freezing. The gel has high strength, significant swelling difference under different temperature and pH environments, fast response rate and good biocompatibility, and can be applied in the fields of sustained drug release and tissue engineering.
Owner:HUNAN UNIV OF TECH