34 results about "Double stimulation" patented technology

The invention discloses an inner-outer double layer stepwise stimulation response delivery nano-carrier, and a preparation method and an application thereof. The preparation method comprises the following steps: dispersing disulfide bond-modified MCM-41 type mesoporous silicon nano-particles in a solution, coupling the surface of the nano-particles with a cationic polymer, and then coupling the surface of the nano-particles with 2,3-DMMA through the cationic polymer to prepare the meso-porous silicon nano-carrier having double stimulation response. The nano-carrier has the outer-to-inner layerstepwise stimulation response characteristic with the outer layer corresponding to pH stimulation response and the inner layer corresponding to redox reduction stimulation response. Drug molecules can be encapsulated into the meso-pores of the nano-particles, and the cationic polymer can bind genes, so the nano-carrier is suitable for preparing drug delivery carriers, nucleic acid delivery carriers or drug-nucleic acid co-delivery carriers.

The invention discloses an acid/base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid/base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.

The invention discloses an artificial electronic cochlea, a speech processor and a method for processing a speech with double stimulation rates. The speed processor and the method are applied to the artificial electronic cochlea, and the method comprises the following steps of: firstly, performing preprocessing, band-pass filtering, half-wave rectification and low-pass filtering on speech signalsto acquire the envelope amplitude of each channel, and adjusting the current amplitude to a working amplitude range; secondly, selecting a plurality of channels of which the envelope amplitudes are more than or equal to a threshold value to form a first part (high-amplitude) channel, and performing pulse sequence modulation with a first (high) stimulation rate on the first part channel; selectinga plurality of channels of which the envelop amplitudes are smaller than the threshold value to form a second part (low-amplitude) channel, and performing pulse sequence modulation with a second (low) stimulation rate on the second part channel; and adopting electronic pulse sequences of the first and second part channels after modulation to stimulate corresponding stimulating electrodes. The artificial electronic cochlea, the speech processor and the method realize the aim of transmitting information on the envelope amplitudes of all the channels to an artificial electronic cochlea patient, and effectively improve the speech recognition effect of the artificial electronic cochlea.

The invention relates to a preparation method and applications of a mesoporous calcium carbonate medicinal composition modified by hyaluronic acid, for effectively simultaneously realizing targeting, controlled release and ultrasonic therapy and ultrasonic imaging combination, and further realizing diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation method comprises the following steps: modifying hyaluronic acid on aminated calcium carbonate obtained by reacting mesoporous calcium carbonate and 3-aminopropyl triethoxysilane, and then loading a micromolecular sonosensitizer, thus obtaining the mesoporous calcium carbonate medicinal composition modified by hyaluronic acid. The preparation method has the advantages that a preparation process is simple, a method is stable and reliable, the production cost is low, and the prepared mesoporous calcium carbonate modified by hyaluronic acid and the medicinal composition of mesoporous calcium carbonate simultaneously have the efficacies of tumor targeting, in vitro and in vivo double-stimulation (in acid environment and under high-intensity focused ultrasonic condition) sensitive medicine release, sonodynamic therapy and ultrasonic imaging combined diagnosis and treatment integration, belong to an innovation in tumor treatment medicines, and have enormous economic and social benefits.

The invention belongs to the technical field of environmental functional material preparation, and relates to a preparation method and application of a photothermal double stimulation response hydrogel containing alpha-cyclodextrin. The method comprises the following steps: firstly preparing alpha-cyclodextrin ester and acrylamido azobenzene, adding the alpha-cyclodextrin ester, the acrylamido azobenzene, methylene bisacrylamide and isopropylacrylamide into a dimethyl sulfoxide solution, and performing ultrasonic shaking to obtain a mixed solution B; adding 2,2'-azobis(2,4-dimethyl)valeronitrile into a dimethyl sulfoxide solution to obtain a mixed liquid D; and finally, adding the mixed liquid D into the mixed liquid B, after mixing is completed, performing a reaction in a water bath to obtain the photothermal double stimulation response hydrogel. According to the method provided by the invention, the cyclodextrin and the photo and temperature structure response units are introduced into the hydrogel prepared by the method, so that the hydrogel can load a large amount of drug molecules, and when an external temperature and an illumination wavelength are changed, the hydrogel can have responsive change of adjusting a release speed of the drug molecules in time; and at the same time, the method is simple and convenient to operate, and the prepared hydrogel is safe and environmentally friendly and has good stability.

The invention discloses double-stimulation response drug based on EGCG and metal ions and a preparation method. The preparation method comprises the following steps: (1) adding water-soluble drug in a dimethyl imidazole aqueous solution, pouring the mixture in water which contains polyvinylpyrrolidone and zinc nitrate, stirring and centrifuging, and washing with deionized water to obtain zeolimidazole skeleton-8 particles which contains the water-soluble drug; and (2) dispersing the zeolimidazole skeleton-8 particles which contains the water-soluble drug in deionized water, adding an epigallocatechin gallate aqueous solution, vibrating to enable the components to be dispersed uniformly, adding a metal salt aqueous solution, vibrating to enable the components to be dispersed uniformly, adding a 3-(N-morpholine) sodium proparesulfonic acid salt buffer solution, vibrating, centrifuging, washing with water, washing with an EDTA aqueous solution, and washing with deionized water to obtain the double-stimulation response drug based on EGCG and metal ions. Preparation conditions are gentle, activity of the water-soluble drug and use safety of a carrier are guaranteed, raw materials are low in cost and easy to obtain, and the preparation process is simple.

The invention discloses a preparation method of a double-stimulation expanding gel particle for preventing gas channeling in the process of carbon dioxide oil displacement. The method includes: 1), dissolving an acrylamide monomer into water to form a solution, adding a crosslinking agent, a temperature response monomer methacrylic acid N, an N-dimethylaminoethyl ester monomer and carbon dioxide response monomer (2-(methacrylenyl oxide) ethyl) dimethyl-(3-sulfonic acid propyl) ammonium hydroxide to the solution with even stirring to form a mixed monomer solution polymerization system, and feeding nitrogen to the polymerization system to remove dissolved oxygen in the system; 2), mixing the mixed monomer with an initiator solution for polymerization reaction. The gel particle continuous expands under CO2 and thermal stimulation, secondary expansion of the gel particle under the acidic environment is achieved, and long-time blocking function can be played.

The invention discloses a triple stimulation responsive core cross-linked polymeric micelle as well as a preparation method and application thereof. The structural formula of the micelle is as shown in the description, wherein x is an integer of 30 to 70, y is an integer of 20 to 50 and the value of x1 is 20% to 50% of that of the x. According to the preparation method, an amphipathic diblock polymer is obtained through atom transfer radical polymerization (ATRP), and is modified by utilizing an azidation reaction; an azidation product can self-assemble to form a core-shell structure in water;and the light, oxidation and reduction triple stimulation responsive core cross-linked polymeric micelle is obtained through click chemistry under the action of a cross-linking agent with redox sensitiveness, anhydrous cupric sulfate and sodium ascorbate. The triple stimulation responsive core cross-linked polymeric micelle provided by the invention has favorable in-vitro stability, can be used for realizing a high-efficiency controlled release behavior of a hydrophobic drug under the double stimulation of light and oxidation or reduction, and has favorable application prospects in the aspects of the delivery and the controlled release of a hydrophobic anti-cancer drug.

The invention discloses a silane coupling agent with double stimulation response and a preparation method and application thereof. The preparation method comprises the following steps that 3-hydroxyl,5-dicyclopentadienyl alkoxy methyl benzoate and bromoalkoxy azobenzene generate 3-dicyclopentadienyl alkoxy,5-azobenzene alkoxy methyl benzoate under base catalysis, and then the 3-dicyclopentadienylalkoxy,5-azobenzene alkoxy methyl benzoate is reduced to a 3-dicyclopentadienyl alkoxy,5-azobenzene alkoxy benzyl alcohol end capping agent; under the protection of nitrogen, the 3-dicyclopentadienylalkoxy,5-azobenzene alkoxy benzyl alcohol, propyl isocyanate triethoxysilane and a catalyst organic tin are added into methylbenzene, the temperature is increased to 80-110 DEG C, and a reaction is carried out to obtain the dicyclopentadienyl azobenzene silane coupling agent. The silane coupling agent can be used for modifying the surface of glass, and the modified glass has the characteristic ofbeing able to be oxidized by ultraviolet light for double stimulation response to change the hydrophilicity of the surface.

The invention belongs to the technical field of beauty and skin care, and particularly relates to facial mask liquid. According to the facial mask liquid, methyl methacrylate, N,N-dimethyl-2-aminoethyl methacrylate and the like are taken as raw materials to prepare composite microgel, a primary amine structure is contained and can bring CO2 stimulation response, the components in auxiliary materials can also introduce a temperature-sensitive effect, the primary amine structure and the auxiliary materials are combined, so that the temperature and CO2 double-stimulation response functions are achieved, a cooling enhancer in a facial mask liquid system acts on a face when a facial mask is used, so that the face temperature is lowered, nervous-humoral regulation can be caused due to the relative cold condition to increase thyroid secretion, so that the dual response of the composite microgel is just stimulated, the effect of massaging the face is achieved, in addition, the release and absorption of other nutrients are also improved in the heat transfer process, the skin compactness and fatigue can be effectively relieved, and a good environment is provided to achieve the absorption ofother nutrient substances and water replenishment function; and the problem that an existing facial mask is single in using effect, and people feel uncomfortable when the skin of the face is moisturized can be solved.

The invention discloses a preparation method of a double-stimulation response type polyurethane micelle. The preparation method comprises the following steps: preparation of an initiator, preparationof an end capping agent, preparation of a vanillin acetal compound, preparation of end-capped polyurethane and preparation of a polyurethane micelle solution. The end-capped pH and temperature double-response type multi-block polyurethane micelle is successfully prepared by combination of technologies of preparing the hydrophilic temperature-sensitive end-capping agent by atom transfer radical polymerization, introducing amphiphilic segments into a polyurethane chain to form micelles and the like. The prepared polyurethane micelle has excellent biocompatibility and biodegradability, and meanwhile has a pH response characteristic and a temperature sensitivity characteristic.

The invention provides a methane locking alarm which can effectively detect methane concentration and personnel information in a firing area. The methane locking alarm comprises a microcontroller which has operation and treatment actions and is characterized in that an input port of the microcontroller is connected with a methane sensor and a human body sensor, an output port of the microcontroller is connected with an LED digital display, and a control port of the microcontroller is connected with a recording and playing chip; the recording and playing chip is connected with an audible and visual alarm via an audio power amplifier. The methane closing alarm is provided with the methane sensor and the human body sensor, so that the detonation of a detonating cap under the condition that working personnel do not evacuate or the concentration of methane gas exceeds standard; the recording and playing chip and the audible and visual alarm are also arranged, the double stimulation of audible signals and visual signals are adopted to warn the working personnel in a burst area.

The invention discloses a dual-purpose illuminating lamp which comprises a lamp body, wherein a buzzer is arranged on the lamp body; two switches, namely a first switch and a second switch, are arranged on a wall body, and connected with lamp body wires correspondingly; the on-off of the lamp body is independently controlled by the first switch; the second switch is in series control with the lamp body and the buzzer; and a timer is arranged on the second switch, and connected in series into the buzzer and a lamp body control loop. The dual-purpose illuminating lamp disclosed by the invention not only can be independently used as a lamp for providing light, but also is equipped with an alarm clock which can be under the fixed-time control; a fixed time can be set as required, and the buzzer makes a sound when the set time point is reached; meanwhile, the lamp body is turned on, thereby achieving double stimulation from the senses of hearing and eyesight as well as a very good wake-up effect; and after a user gets up, the lamp body and the buzzer can be turned off through the second switch.

The invention belongs to the field of biological medicine, and in particular relates to a rat model with the symptom of cold fluid retention in lung of bronchial asthma and a construction method of the rat model. The construction method comprises the following steps: (1) injecting antigen liquid into the abdominal cavities of rats so as to sensitize the rats; when asthma is excited after two weeks, keeping the rats in various groups in a semi-closed rat cage, and exciting the rats through aerosol inhalation of egg albumin normal saline; and (2) in an exciting period, applying double-stimulation, namely chilling stimulation and tiring stimulation, to the rats, so that the rat model with the symptom of cold fluid retention in lung of bronchial asthma is obtained.

The invention discloses a light-magnetism dual stimulus-responsive surfactant. The surface tension and the contact angle of the surfactant change under the action of light and a magnetic field, in other words, the surfactant has dual stimulus responsibility.

The invention relates to a massage device, and belongs to the field of massage equipment. The massage device comprises a stand column having the size corresponding to the height of a human body, a connecting mechanism connected on the stand column in a clamping manner, and a circumduction mechanism sleeving the periphery of the stand column through the connecting mechanism. The circumduction mechanism can rotate around the stand column so as to adjust the appropriate height and the appropriate inclination angle, so that a user can simultaneously make contact with the stand column and the circumduction mechanism at any angle. One end of body muscles is kneaded and pressed by the stand column and the other end of the body muscles is convoluted and dialed to rotate by the circumduction mechanism, just as strings are pressed by one hand and the strings are dialed by the other hand during guitar playing; produced double stimulation can quickly eliminate muscle stiffness and instinct slidingand antagonism of the muscles, the effect of releasing muscle fascia adhesion can be quickly achieved.