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Rat model with symptom of cold fluid retention in lung of bronchial asthma and construction method of rat model

A technology for bronchial asthma and a construction method, which is applied to the rat model of bronchial asthma and the field of construction with cold drink in the lung, can solve the problems of different replication targets, and achieves the effect of simple modeling method, easy operation and promotion.

Inactive Publication Date: 2018-03-02
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Claims
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Problems solved by technology

Although based on different theoretical systems, the replication targets are different, but the final result is the same, even if animals have similar lesions to humans

Method used

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  • Rat model with symptom of cold fluid retention in lung of bronchial asthma and construction method of rat model
  • Rat model with symptom of cold fluid retention in lung of bronchial asthma and construction method of rat model
  • Rat model with symptom of cold fluid retention in lung of bronchial asthma and construction method of rat model

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Construction and Evaluation of Rat Model of Bronchial Asthma with Cold Drink Accumulation in the Lung Syndrome

[0024] 1 material

[0025] 1.1 Experimental animals and grouping

[0026] 52 healthy male Winter rats, with a body weight of 190 ± 10g, were divided into normal group (group A), model group (group B), Xiaoqinglong decoction group (group C) and Wenyanghua decoction group (group D). There were 13 rats in each group.

[0027] 1.2 Experimental reagents and instruments

[0028] Physiological saline; ovalbumin (OVA) 25g / bottle; inactivated pertussis vaccine 2ml / bottle; aluminum hydroxide 500g / bottle; ultrasonic nebulizer.

[0029] Xiaoqinglong Decoction (Ephedra, Guizhi, Raw Paeoniae Alba, Dried Ginger, Schisandra, Pinellia, Licorice 10g each, Asarum 5g), Wenyanghua Decoction (Ephedra, Guizhi, Raw Paeoniae Alba, Dried Ginger, Schisandra , Pinellia, Radix Glycyrrhizae 10g each, Herba Asarum 5g, Ginseng 10g, Astragalus 25g), all purchased from the Chin...

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Abstract

The invention belongs to the field of biological medicine, and in particular relates to a rat model with the symptom of cold fluid retention in lung of bronchial asthma and a construction method of the rat model. The construction method comprises the following steps: (1) injecting antigen liquid into the abdominal cavities of rats so as to sensitize the rats; when asthma is excited after two weeks, keeping the rats in various groups in a semi-closed rat cage, and exciting the rats through aerosol inhalation of egg albumin normal saline; and (2) in an exciting period, applying double-stimulation, namely chilling stimulation and tiring stimulation, to the rats, so that the rat model with the symptom of cold fluid retention in lung of bronchial asthma is obtained.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a rat model of bronchial asthma with cold-drink accumulation in the lung syndrome and a construction method thereof. Background technique [0002] In the process of medical experiments, establishing animal models to replace real research objects has become a common method in medical research. [0003] TCM experiment is a means of researching and developing TCM under the guidance of TCM theory and using modern scientific research methods and technologies. For Chinese medicine, it takes "syndrome" as the main body of diagnosis and treatment, so the main purpose of TCM modeling is to establish the corresponding "syndrome" model. The modeling methods of TCM animal models are roughly divided into three types: one is to establish animal models by simulating traditional Chinese medicine etiology, including single-factor modeling and compound-factor modeling; the other is to repli...

Claims

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Application Information

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IPC IPC(8): A61K39/35A61K39/10A61K49/00
CPCA61K39/099A61K39/35A61K49/0008A61K2300/00
Inventor 张庆祥
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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