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A kind of high-strength cellulose-based nanocomposite temperature, pH dual stimulus responsive gel and preparation method thereof

A cellulose-based, nano-composite technology, used in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve the problems of inability to human body environment, poor responsiveness, weak mechanical properties, etc., to ensure biocompatibility, Guarantee the effect of surface characteristics and strength improvement

Inactive Publication Date: 2018-07-27
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the whole, although natural macromolecular gel systems have been developed and have various functions, they still have some common defects as tissue engineering and drug sustained-release materials, such as generally weak mechanical properties, low responsiveness, and inability to fully integrate with the human environment. fit, and the performance deteriorates with the degradation, etc. For these common defects, some researches have been done to improve them

Method used

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  • A kind of high-strength cellulose-based nanocomposite temperature, pH dual stimulus responsive gel and preparation method thereof
  • A kind of high-strength cellulose-based nanocomposite temperature, pH dual stimulus responsive gel and preparation method thereof
  • A kind of high-strength cellulose-based nanocomposite temperature, pH dual stimulus responsive gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 7.32g (N-isopropylacrylamide-N,N-dimethylaminoethyl methacrylate) copolymer, 0.27g 2-ethyl-4-methylimidazole, 1.2g eight-arm epoxypropyl cage silsesquioxane, dissolved in 50.6g of a mixed solution of DMF and THF with a mass ratio of 1:1, stirred at room temperature for 30 minutes to form a pre-spinning solution, and the pre-spinning solution was placed in a needle electrospinning device, The solution flow rate, voltage and spinning distance were set to 0.6 ml / h, 13 kV and 17 cm. After spinning, the responsive polymer nanofibers were heated to 160 degrees in a vacuum and dried for 4 hours before use;

[0044] (2) Dissolution of cellulose: prepare 6wt% NaOH 4wt% urea aqueous solution, then use G2 funnel to filter and use it as a cellulose solvent, weigh 400g of the solution, disperse 32.1g of cellulose in the solvent, and stir at room temperature for 5 minutes Put it in the refrigerator and freeze it for 12 hours. The frozen solid sample was thawed and stirred at room tem...

Embodiment 2

[0056] 11.56g (N-isopropylacrylamide-N,N-dimethylaminoethyl methacrylate) copolymer, 0.41g 2-ethyl-4-methylimidazole, 2.12g eight-arm epoxypropyl cage silsesquioxane, dissolved in 81.4g of a mixed solution of DMF and THF with a mass ratio of 1:1, stirred at room temperature for 30 minutes to form a pre-spinning solution, and the pre-spinning solution was placed in a needle electrospinning device, The solution flow rate, voltage and spinning distance were set to 0.6 ml / h, 13 kV and 17 cm. After spinning, the nanofibers were heated to 160 degrees in a vacuum and dried for 4 hours for later use;

[0057] (2) Dissolution of cellulose: prepare 6wt% NaOH 4wt% urea aqueous solution, then use G2 funnel to filter it as the cellulose solvent, weigh 600g solution, disperse 48.5g cellulose in the solvent, stir at room temperature for 5 minutes Put it in the refrigerator and freeze it for 12 hours. The frozen solid sample was thawed and stirred at room temperature, and finally a colorless ...

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Abstract

The invention relates to a preparation method of a high-strength cellulose-based nanocomposite temperature-pH dual-stimuli-responsive gel. The gel uses POSS cross-linked responsive polymer nanofibers obtained by electrospinning as a fiber reinforcement, which is introduced into the dissolved cellulose solution, and a composite gel is formed by cross-linking the cellulose and freezing. The gel has high strength, significant swelling difference under different temperature and pH environments, fast response rate and good biocompatibility, and can be applied in the fields of sustained drug release and tissue engineering.

Description

technical field [0001] The invention belongs to a preparation method of a cellulose-based hydrogel, in particular to a preparation method of a hydrogel which has high strength and can realize rapid reversible response to temperature and pH value changes. Background technique [0002] Polymer gel refers to a system composed of a three-dimensional network structure of polymer compounds and a solvent, in which the polymers are connected by van der Waals force, chemical bond force, physical winding force, hydrogen bond force, etc. Since it is a three-dimensional network structure, it cannot be dissolved by solvents, and at the same time, it can be dispersed in solvents and can maintain a certain shape. Although the solvent cannot dissolve the polymer with a three-dimensional network structure, the solvophilic group in the polymer compound can be affected by the solvent to swell the polymer, which is also the reason for the formation of a polymer gel. Responsive polymer gel is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L1/26D06M15/09C08F220/54C08F8/42D01F6/28D01F1/10D01D5/00
Inventor 陈一
Owner HUNAN UNIV OF TECH
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