Application of vitamin E polyethylene glycol succinate and derivatives thereof in preparation of hydrogel nanoparticle preparation of prodrug of hydrophilic medicine

A technology of polyethylene glycol succinate and hydrophilic drugs, which is applied in the field of pharmaceutical preparations to achieve strong biocompatibility and reduce non-specific phagocytosis.

Inactive Publication Date: 2015-02-25
SUZHOU NASIDA BIO PHARMA
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  • Abstract
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  • Claims
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Problems solved by technology

[0008] Vitamin E polyethylene glycol succinate (TPGS) and its derivatives have n...

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  • Application of vitamin E polyethylene glycol succinate and derivatives thereof in preparation of hydrogel nanoparticle preparation of prodrug of hydrophilic medicine
  • Application of vitamin E polyethylene glycol succinate and derivatives thereof in preparation of hydrogel nanoparticle preparation of prodrug of hydrophilic medicine
  • Application of vitamin E polyethylene glycol succinate and derivatives thereof in preparation of hydrogel nanoparticle preparation of prodrug of hydrophilic medicine

Examples

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Embodiment 1

[0038] Example 1 Vitamin E polyethylene glycol succinate / poly-L-lysine copolymer (TPGS-PLL) is used to prepare the prodrug hydrogel nanoparticle formulation of cisplatin

[0039] Cisplatin is a commonly used anticancer drug approved by the US FDA for the treatment of bladder cancer, cervical cancer, malignant mesothelioma, non-small cell lung cancer, ovarian cancer, head and neck cancer Drugs for squamous cell carcinoma, testicular cancer. Cisplatin has a certain solubility in water, and it is usually dissolved in normal saline (0.9% NaCl) for injection. Cisplatin dissolved in normal saline has an elimination half-life of 1 hour in humans with normal renal function. Usually 2-3 hours after the end of the injection or infusion, 90% of the cisplatin will be irreversibly combined with the protein in the blood and be metabolized. The normal saline preparation of cisplatin has no target, and it will accumulate in various organs of the body in the human body, causing strong side e...

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Abstract

The invention provides application of vitamin E polyethylene glycol succinate (TPGS) and derivatives thereof in preparation of a hydrogel nanoparticle preparation of prodrug of a hydrophilic medicine. The application disclosed by the invention has the following technical effects: (1) the prepared preparation is a nano-scale biological preparation; (2) sustained release of the hydrophilic medicine is realized; (3) the biocompatibility of the hydrogel nanoparticle is enhanced by virtue of the vitamin E polyethylene glycol succinate; and (4) TPGS and derivatives thereof are applicable to co-delivery of multiple medicines so as to achieve a synergistic effect.

Description

technical field [0001] The invention relates to the application of vitamin E polyethylene glycol succinate and its derivatives in the preparation of prodrug hydrogel nanoparticle preparations of hydrophilic drugs, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] In the United States, it usually takes 10-15 years and nearly one billion dollars of capital investment for a new drug to go from discovery to clinic. The success of a new drug largely depends on its clinical formulation. This is due to the fact that the formulation greatly affects the pharmacokinetics, pharmacokinetics and biodistribution of the drug. As a new type of drug preparation, nanoparticles can not only significantly improve pharmacokinetics, pharmacokinetics and biodistribution, greatly increase the rate of cellular uptake, but also achieve the advantages of slow release, controlled release and targeting of drugs. So far, there have been a few nanoparticle ...

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Application Information

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IPC IPC(8): A61K47/48A61K47/34A61K9/06A61K9/14
Inventor 冯思慎赵婧
Owner SUZHOU NASIDA BIO PHARMA
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