Dual-controllable medicine release structure with SERS (Surface Enhanced Raman Scattering) signal and preparation method of dual-controllable medicine release structure

A drug and nano-drug carrier technology, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, inorganic non-effective ingredients, etc., can solve problems that affect the accurate tracking of drug carrier particles, overlapping spectra of different components, and broad fluorescence spectra. , to achieve the effects of avoiding drug leakage in advance, good controllable release characteristics, and simple preparation method

Inactive Publication Date: 2013-10-09
SOUTHEAST UNIV
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used fluorescence technology has the advantages of being fast and simple; however, the fluorescence spectrum is wide, and spectral overlap between different components is prone to occur, thus affecting the accurate tracking of drug carrier particles

Method used

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  • Dual-controllable medicine release structure with SERS (Surface Enhanced Raman Scattering) signal and preparation method of dual-controllable medicine release structure
  • Dual-controllable medicine release structure with SERS (Surface Enhanced Raman Scattering) signal and preparation method of dual-controllable medicine release structure
  • Dual-controllable medicine release structure with SERS (Surface Enhanced Raman Scattering) signal and preparation method of dual-controllable medicine release structure

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Experimental program
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Effect test

Embodiment 1

[0038] The 4-mercaptobenzoic acid (4MBA) molecule is used as the SERS marker, the mesoporous silica is used as the drug carrier, and the copolymer-liposome is used as the double-response gate capping. The schematic diagram of the carrier particle structure is shown in figure 1 .

[0039] 1) Co-precipitation method to prepare Raman molecularly labeled silica-coated metal nanoparticles. 8 mL of silver colloid was centrifugally dispersed into 5 mL of alcohol and stirred, then 10 μL of 4-mercaptobenzoic acid (4MBA) solution was added, and after 15 minutes, 100 μL of ammonia water and 20 μL of tetraethoxysilane (TEOS) were added to react for 10 h. The product is metal nanoparticles coated with Raman molecules labeled with silica.

[0040] 2) Prepare mesoporous silica-coated metal nanoparticles by co-precipitation method. Centrifuge the nanoparticle solution prepared in 1) at 6500 rpm once every 10 minutes, disperse it into 25 mL of water, add it to 15 mL of alcohol containing 1...

Embodiment 2

[0046] 4-mercaptobenzoic acid (4MBA) molecule is used as SERS marker, mesoporous silica is used as drug carrier, copolymer-liposome is used as double-response gate capping, and doxorubicin (DOX) is used as drug Molecularly prepare nano-drug carrier particles, and finally use pH=7.4, 6.8, 5.5 to trigger their drug release respectively.

[0047] 1) Co-precipitation method to prepare Raman molecularly labeled silica-coated metal nanoparticles. 10 mL of silver colloid was centrifugally dispersed into 8 mL of alcohol and stirred, then 15 μL of 4-mercaptobenzoic acid (4MBA) solution was added, and after 15 minutes, 300 μL of ammonia water and 10 μL of tetraethoxysilane (TEOS) were added to react for 10 h. The product is metal nanoparticles coated with Raman molecules labeled with silica.

[0048] 2) Prepare mesoporous silica-coated metal nanoparticles by co-precipitation method. Centrifuge the nanoparticle solution prepared in 1) at 6500 rpm once every 10 minutes, disperse it into...

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Abstract

The invention aims to provide a dual-controllable medicine release structure with an SERS (Surface Enhanced Raman Scattering) signal and a preparation method of the dual-controllable medicine release structure. A nano medicine carrier particle has a four-layer onion structure, a core at the innermost layer is a metal particle marked with Raman molecule, thin-layer solid silicon dioxide is wrapped outside the metal particle, then mesoporous silicon dioxide used for loading medicine is wrapped outside the thin-layer solid silicon dioxide, and a copolymer-lipidosome with temperature and pH response is wrapped on a shell at the outermost layer. In addition, the medicine is loaded in holes of the mesoporous silicon dioxide in a physical absorbing manner, the lipidosome on the surface is equivalent to a cover, and under the outside stimulation triggering of Ph and temperature, a gating is converted into an 'opening' state from a 'closing' state, therefore, medicine molecules are released. The carrier particle is capable of effectively increasing the efficiency of cancer chemotherapy.

Description

technical field [0001] The invention relates to the technical field of nanomaterial preparation, in particular to a double-controllable drug release structure with surface-enhanced Raman scattering (SERS) signals and a preparation method thereof. Background technique [0002] Nano-drug carrier is a sub-particle drug carrier delivery system belonging to the category of nano-scale microcosm. With the continuous development of nanomaterial preparation technology, multifunctional drug carrier particles based on nanomaterials are gradually becoming the focus of domestic and foreign researchers. Encapsulating drugs in sub-particles can effectively increase the amount of targeted drug delivery, reduce toxic and side effects, and improve the effective utilization of drugs by increasing the gating switch of the external mechanism. [0003] At present, how to improve the efficiency of cancer chemotherapy and reduce its side effects is an urgent problem to be solved. In the construct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/04A61K47/02A61K9/16
Inventor 王著元武欣崔一平钟嫄
Owner SOUTHEAST UNIV
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