81 results about "Porphyrin molecule" patented technology

The invention discloses a porphyrin derivative nano-composite preparation applied in photodynamic therapy and photothermal therapy of rheumatoid arthritis and an application thereof. The invention discloses an experimental method of a composite reagent of a water-soluble porphyrin derivative and a nano-material. The composite reagent has stable fluorescence characteristic and excellent biocompatibility. According to the composite reagent, drug release detection and tracing of an inflammation area can be realized, and enrichment in the inflammation area can be achieved through porphyrin molecule absorption of the nano-material. The experimental method provided by the invention is easy to implement, and has low toxicity and high specificity. The porphyrin derivative in the obtained composite reagent can undergo violet light excitation to generate singlet oxygen. The nanometer material in the composite reagent has excellent photothermal effect under the red light excitation condition. Drug enrichment and multi-model treatment by photodynamic therapy and photothermal therapy for inflammation disease can be realized, and the porphyrin derivative nano-composite preparation has wide medical clinical application value and prospect.

The invention discloses a quantum dot rate fluorescence probe for zinc ion detection and a detection method of the quantum dot rate fluorescence probe. The quantum dot rate fluorescence probe for zinc ion detection is prepared from CdSe/ZnS quantum dots for emitting green fluorescence, and CdSe/CdZnS/ZnS quantum dots for emitting yellow fluorescence and porphyrin molecules in an electrostatic assembly manner; the molar concentration ratio of the two quantum dots to porphyrin is 1 to 10; the outer layers of the two quantum dots are wrapped by positively charged silicon dioxide shell layers; and the porphyrin molecules are negatively charged sulfur-based porphyrin molecules. By virtue of a rate fluorescence detection method, the quantum dot rate fluorescence probe adopts a simple process, is low in price, good in repeatability, suitable for the environment, drinking water and body liquid, and has a good application prospect.

The invention discloses a peroxide mimic enzyme and preparation and applications thereof, and relates to a horse radish peroxidase bio-mimetic technology, namely a technology of orderly fixing natural enzyme prothetic groups that are porphyrin molecules on the surface of a mass-produced carbon nitride nanosheet in an axial coordination manner so as to produce a mimic enzyme with a structure approaching a natural enzyme protein structure. The various catalytic kinetics indexes of the mimic enzyme are equivalent with that of a natural enzyme. On this basis, a general peroxide mimic enzyme CoII-Hemin@g-C3N4 nanometer biological probe is designed, and a high-sensitivity high-specificity biosensor used for detection of the H7N9 avian influenza virus is constructed, wherein the biosensor has characteristics of stable electrogenerated chemiluminescence output signals and a low detection lower limit. The mimic enzyme can be used in the aspects of biomedicine, clinical diagnosis, environment monitoring, judicial expertise, and the like.

The invention discloses a method for preparing a phenylamino porphyrin self-assembled nanomaterial by adopting a co-solvent method. The method comprises the following steps: 1) preparing CTAB, SDS, MTAB or P123 aqueous solution; 2) preparing a DMF solution of phenylamino porphyrin; and 3) adding the solution in the step 2) into the solution in the step 1), stirring for 40-50h at 25 DEG C, and performing centrifugal separation, to obtain a solid, namely the phenylamino porphyrin self-assembled nanomaterial. The method has the advantages of the original methods, the yield problem can be solved as a great amount of phenylamino porphyrin is dissolved in the DMF solution; by taking micelle as a confinement template, the self assembling can be conducted under the assistance of an emulsifying agent by changing the soluble state of phenylamino porphyrin molecules into a non-soluble state through the weak phase interaction between molecules, finally the porphyrin molecule assembled body with controllable shapes can be obtained, and the assembled material has an important role in the fields of photocatalysis, nanodevices and the like.

The invention relates to a supported metal bismuth particle composite material which is characterized in that metal bismuth particles are supported on a porous carbon carrier through a coupling agent with amino groups, and the particle size of the metal bismuth particles is 5-30nm. The preparation method comprises the following steps: loading tetraaminophenyl porphyrin molecules on porous carbon through simple two-step impregnation adsorption to form a modified porous carbon composite material, and then carrying out second-step impregnation adsorption on the modified porous carbon composite material and bismuth metal salt under a sodium borohydride reduction condition. Benefited from the confinement effect of porous carbon and the special stabilizing effect of the molecular coupling agent, the bismuth metal small nanoparticles are fixed on the porous carbon carrier in a strong binding form, the loading capacity is high, and the activity is high, so that the molecular coupling agent plays a role in enhancing the interaction between the bismuth metal nano particles and the carrier, and the self structure is not changed under the reduction condition. The supported metal bismuth particle composite material is used for preparing formic acid by carbon dioxide epoxy, has excellent catalytic activity and stability, and has obvious industrial advantages.

The invention discloses a preparation method for a porphyrin photosensitizer with visual photodynamic therapy characteristic. According to the method, water-soluble porphyrin molecule react with soluble nitrate under acidic, shaded and room-temperature conditions so as to obtain a reaction system containing the porphyrin photosensitizer, and the system is subjected to treatment, thereby obtaining the porphyrin photosensitizer which is a nano aggregate and has cell imaging and photodynamic therapy characteristics. In addition, the preparation method provided by the invention is simple in process, easy in operation and relatively low in cost and has no need of complicated synthesis steps and aftertreatment steps, so that the popularization to production is facilitated.

The invention synthesizes novel porphyrin-chrysin derivatives. Porphyrin molecules are used as a carrier, the tumor tissue aggregation effect of the porphyrin molecules is used, meanwhile, the property that the porphyrin molecules can produce singlet oxygen to kill tumor cells is used and combined with natural anti-tumor activity of chrysin, so that the novel anti-tumor compounds are obtained, anda new direction is provided for research on anti-tumor drugs.

The invention provides conjugated dendritic pure red light emitting electroluminescent material, and a preparation method and application thereof. The material has a conjugated dendritic molecule which takes porphyrin as a core, truxene as a bridge and monofluoride as an antenna molecular and has a structural formula A. The material is prepared by the Lindsey condensation reaction of a derivative having a methanoyl of the truxene and the porphyrin. The method introduces a truxene system having a hydrotropic group to a metaposition of a porphyrin molecule to improve the solubility of the material and suppress fluorescence self-quenching, and increases intramolecular and intermolecular energy transfer through derivatization at 2, 7, 12-position of the truxene, so as to obtain high-efficiency pure light emission. The conjugated dendritic molecules are used as materials for a light emitting layer of an organic electroluminescent diode device and made into films by a simple spin coating process, and generate high-efficiency pure red light electrofluorescence without doping.

The invention provides a crosslinking hole transport layer material and a preparation method thereof, and is applied into an OLED display panel. The OLED display panel comprises a substrate and OLED devices manufactured on the substrate at intervals; the OLED devices comprise a cathode, a hole transport layer, a light-emitting layer, an electron transport layer and an anode. The preparation methodof the hole transport layer comprises the following steps: providing a precursor solution comprising precursor molecules and an organic solvent, wherein the precursor molecules are porphyrin molecules or phthalocyanine molecules, and the precursor molecules comprise crosslinking radicals; preparing the pecursor solution onto the cathode, carrying out heat treatment so that a crosslinking reactionoccurs on the precursor solution to form a uniform and stable polymer film, namely the hole transport layer, so that the interfacial property of an ink-jet printing device is improved effectively, and the performance of the device is further promoted.

The invention discloses a micro-nano reactor based on phthalocyanine bridging methylation cyclodextrin, and in particular relates to a supermolecule tubular micro-nano reactor for catalyzing cross coupling reaction generated by aryl halide and an organic boric agent. The micro-nano reactor has such a building mode that porphyrins molecules are enveloped into a cavity of methylation cyclodextrin; a hydrophilic clathrate is adopted to construct a hydrophilic surface of the reactor and is exposed to a water phase; hydrophobic alkyl chains are crossed with each other to form a hydrophobic interlayer of the micro reactor. According to the preparation method, the micro-nano reactor is obtained by supermolecules self-assembly of a phthalocyanine axial bridging methylation cyclodextrin host compound and an amphipathy porphyrin guest compound. The palladium-loaded micro-nano reactor prepared by the method has the advantages that the synthesis route is simple, the reaction conditions are mild, the aftertreatment is simple and convenient, and the yield is very high; the micro-nano reactor is suitable for amplification synthesis and actual production application. The coupling reaction yield is high, and the use of a toxic organic solvent is avoided; the micro-nano reactor serving as a catalyst for the coupling reaction has a wide application prospect.

The invention discloses a tumor phototherapy reagent based on cell membrane coating. The tumor phototherapy reagent is high molecular weight chitosan of which the side chain contains a photosensitizer molecule and a polyethylene glycol molecule. The invention further discloses a preparation method of the tumor phototherapy reagent and application of the tumor phototherapy reagent to preparation of a photosensitizer. Compared with the prior art, the reagent has the advantages that the toxicity to cells is very low under the condition of no irradiating, and under the irradiation of light with certain wavelength, the photodynamics toxicity is improved greatly when being compared with that of free porphyrin molecules. Above all, the self quenching effect between porphyrin molecules is solved effectively, and the cell membrane imaging and photodynamics tumor therapy based on the porphyrin molecules are achieved.

The invention provides nanocomposite particles and a preparation method thereof. The preparation method of the nanocomposite particles comprises the following steps: dissolving ZrCl4 in N,N-dimethylmethylamide so as to form a ZrCl4 solution; sequentially adding terephthalic acid, benzoic acid, hydrochloric acid and meso-tetra(4-carboxyphenyl)porphine into the ZrCl4 solution so as to obtain organometallic framework nanoparticles embedded with porphyrin molecules; adding the organometallic framework nanoparticles into a buffer solution; and then, adding dopamine so as to form polydopamine by polymerization of dopamine molecules, thereby wrapping outer surface of the organometallic framework nanoparticles with the polydopamine so as to form nanocomposite particles with a core-shell structure,wherein thickness of the polydopamine layers is 5-50nm and size of the nanocomposite particles is 60-500nm. The nanocomposite particles prepared by the preparation method are uniform in appearance, good in dispersivity, low in biological toxicity, and excellent in photothermal effects and photodynamic therapeutic effects; and thus, the nanocomposite particles have good curative effects on tumors.

The invention discloses a fish meat freshness visual intelligent label based on metal porphyrin metal-organic frameworks (MOFs) and a preparation method and application of the fish meat freshness visual intelligent label. The metal porphyrin MOFs are used as a color developing agent, and the fish meat freshness visual intelligent label comprises a fiber membrane with the surface biomimetic mineralized with the metal porphyrin MOFs. The preparation method comprises the steps that the metal porphyrin MOFs are loaded on the surface of the fiber membrane in a biomimetic mineralization mode throughinducing, and the fiber membrane with the surface biomimetic mineralized with the metal porphyrin MOFs is placed between a piece of paper and a plastic film for thermoplastic composition. The fish meat freshness visual intelligent label utilizes protein and polysaccharide to induce a MOFs biomimetic mineralization technology, porphyrin is used as organic ligand and metal ions are used as nodes, the problem that porphyrin molecules are prone to aggregating and the indicating effect is poor are effectively solved, the sensitivity and accuracy of the intelligent label are improved by a porous structure of the metal porphyrin MOFs, the rotting condition of fish is indicated simply, quickly and conveniently, and the quality safety of the fish is ensured.

The invention provides a tailed porphyrin compound modified by N1-substituted 3, 4-dihydropyrimidine-2-ketone and a preparation method thereof. N1-substituted 3, 4-dihydropyrimidine-2-ketone small molecular compounds with biological activity are introduced to porphyrin molecules to form the novel porphyrin compound. The preparation method includes: fully dissolving monohydroxy porphyrin, adding the N1-substituted 3, 4-dihydropyrimidine-2-ketone, anhydrous potassium carbonate and acetone, and stirring at normal temperature; and removing the acetone after full reaction, adding water, filtering, drying and separating to obtain the tailed porphyrin compound. The tailed porphyrin compound modified by N1-substituted 3, 4-dihydropyrimidine-2-ketone prepared by the method can be easily dissolved in the acetone, so that use of the porphyrin compound is facilitated. The preparation method is simple, mild in reaction conditions, easy in raw material recycling, and simple and safe to operate, and accordingly a production method of novel photosensitizers is provided for photodynamic therapies.

The invention discloses a preparation method and application of a metal ion modified MOF micro/nano structure in hydrogel, and belongs to the field of organic nano photocatalysis. The preparation method comprises the following steps: reacting a porphyrin ligand with a metal cluster to obtain a porphyrin MOF micro/nano structure, then blending the porphyrin MOF micro/nano structure with a sodium alginate (SA) aqueous solution, freezing and forming, putting the mixture into an excessive amount of a divalent metal salt (M<2+>) solution, and carrying out cross-linking curing to obtain the SA-M<2+>-MOF hydrogel ball. According to the invention, by utilizing a method of coordination of cross-linked metal ions and porphyrin molecules, while an MOF micro/nano structure is effectively modified, the MOF micro/nano structure is uniformly and firmly embedded into an SA hydrogel ball skeleton, so that the recyclability of the SA hydrogel ball is improved; the method is simple and easy to implement, and an experimental basis is provided for controllable and integral assembly of organic nano materials; the application of the obtained SA-M<2+>-MOF in photocatalytic degradation of organic dye is researched, and the result shows that the structure has efficient photocatalytic activity; and possibility is provided for wide application to pollution treatment and energy exhaustion.

The invention discloses a preparation method of a fluorescent composite material based on MOFs/porphyrin. The method comprises the following steps: dissolving zinc nitrate, terephthalic acid, N-polyvinylpyrrolidone and lauric acid into N-N dimethylacetamide, and performing hydrothermal reaction, cooling, centrifugation, ethanol washing and vacuum drying, so as to obtain an H-MOF-5 nanosheet; dissolving the H-MOF-5 nanosheet into an ethanol solution, and performing ultrasonic mixing, so as to obtain a mixed solution; stirring, adding porphyrin into the mixed solution, ensuring that the porphyrin is completely dissolved, and continuously stirring at a room temperature, so as to obtain a mixture; performing centrifugation on the mixture, separating out a product, and performing ethanol washing and centrifugation and vacuum drying, so as to obtain an H-MOF-5/TCPP fluorescent composite material. The method has the advantages that porphyrin molecule is loaded to the H-MOF-5 nanosheet, the aggregation of the porphyrin molecule is prevented, the water solubility and fluorescence property of the porphyrin molecule is improved, and the morphology consistency of the material before and aftercompounding is kept, so that the fluorescent composite material has an important effect in terms of fluorescence sensors.

The invention relates to the field of intelligent food packaging, and particularly relates to a metalloporphyrin/agarose freshness indicating label and a preparation method thereof. According to the freshness indicating label, agarose gel is used as a base material, the agarose gel comprises a metalloporphyrin color developing agent and a plasticizer which are uniformly dispersed in the agarose gel, the acid-base detection sensitivity of porphyrin molecules is high, and in combination with the good film-forming performance of the agarose gel, the prepared metalloporphyrin/agarose freshness indicating label can simply, rapidly and conveniently indicate the decay condition of meat products, and meanwhile the preparation method is simple, novel, low in cost, good in response performance, andhas wide application prospects.

In a sensing element for a nitrogen oxide molecule of the present invention, a sensing portion that is to be bonded to a nitrogen oxide molecule to be sensed is fixed between paired metal electrodes through connecting portions. The sensing portion is a single porphyrin molecule or a single porphyrin derivative molecule each having, as a central metal thereof, iron or cobalt. The connecting portions are each a mercaptophenyleneethynyl group bonded to the single porphyrin molecule or the single porphyrin derivative molecule. Provided are a sensing element for nitrogen oxide molecule, a sensing apparatus for nitrogen oxide molecule, and a method for sensing nitrogen oxide molecule.

The invention discloses a porphyrin-crown ether compound, which comprises a metallic porphyrin molecular skeleton and a crown ether complexation unit, as well as a linker connecting the two fragments in series. The compound has a general formula of: [Metallic porphyrin]-Linker-[Crown ether], the Metallic porphyrin represents metallic porphyrin, the Crown ether represents crown ether, and the Linker is an alkyl bond or an amide bond. In the invention, a metal ion on porphyrin can coordinate with different anions and cause optical signal changes of ultraviolet and fluorescence of a porphyrin chromophore, while the crown ether undergoes complexation with a counter cation (like Na<+>, K<+>, NH4<+>, etc.), preferably with a cation matching with the crown ether in size. For anions of different stereo configurations, the size of an intramolecular hole can be controlled by adjusting the length of a linking unit so as to make the intramolecular hole matching with an anion mutually. The obtained sensor molecule can detect inorganic anions with a concentration low to 0.1ppm (like C1<->, I<->, CN<->, SCN<->, and ClO4<->, etc.) in a water phase medium. The detection technology of high sensitivity in the invention is of great significance in environment analysis, biomedicine and other aspects.

Disclosed herein are reusable composite materials for scavenging oxygen, methods of preparing the composite materials and method of using them. The composite materials contain porphyrin molecules and a metal oxide comprised within the porphyrin. The metal oxide is oxidizable in the presence of oxygen and the oxidation of the metal oxide is reversible upon exposure of the composite material to light of a fixed wavelength.