35 results about "Hyperpolarizability" patented technology

The invention belongs to the technical field of liquid crystal laser sensing, and relates to an estradiol detection device based on a liquid crystal-gold nanoparticle laser sensor. The optical flow control optical fiber is used as an echo wall resonator. In order to realize an estradiol sensing function, the DNA aptamer is modified on the inner surface of the optical flow control optical fiber to realize specific capture of estradiol. After the aptamer is combined with estradiol, the interaction between the aptamer and estradiol triggers the aptamer imaging change, so that the liquid crystal molecule realizes the conversion from a bipolar type to a radial type, and the conversion leads to the reduction of the refractive index, thereby causing the blue shift of the spectrum. By virtue of a local disturbance effect based on the gold nanoparticles, a quadruple synergistic effect of hyperpolarizability change of modified biomolecules, liquid crystal molecule orientation and echo wall mode resonance, an opportunity is provided for sensing and amplifying subtle detection of a target binding event. The problem of low sensitivity caused by common naked eye observation or wide spectrum monitoring in a liquid crystal microdroplet sensor is solved.