Micro-nano reactor based on phthalocyanine bridging methylation cyclodextrin and preparation of micro-nano reactor

Abstract

The invention discloses a micro-nano reactor based on phthalocyanine bridging methylation cyclodextrin, and in particular relates to a supermolecule tubular micro-nano reactor for catalyzing cross coupling reaction generated by aryl halide and an organic boric agent. The micro-nano reactor has such a building mode that porphyrins molecules are enveloped into a cavity of methylation cyclodextrin; a hydrophilic clathrate is adopted to construct a hydrophilic surface of the reactor and is exposed to a water phase; hydrophobic alkyl chains are crossed with each other to form a hydrophobic interlayer of the micro reactor. According to the preparation method, the micro-nano reactor is obtained by supermolecules self-assembly of a phthalocyanine axial bridging methylation cyclodextrin host compound and an amphipathy porphyrin guest compound. The palladium-loaded micro-nano reactor prepared by the method has the advantages that the synthesis route is simple, the reaction conditions are mild, the aftertreatment is simple and convenient, and the yield is very high; the micro-nano reactor is suitable for amplification synthesis and actual production application. The coupling reaction yield is high, and the use of a toxic organic solvent is avoided; the micro-nano reactor serving as a catalyst for the coupling reaction has a wide application prospect.

Description

【Technical field】 [0001] The invention relates to the field of organic catalytic reactions, in particular to a micro-nano reactor based on phthalocyanine-bridged methylated cyclodextrin and its preparation. 【Background technique】 [0002] Suzuki–Miyaura coupling generally refers to the cross-coupling reaction of aromatic halides and organoboron reagents. The Suzuki–Miyaura reaction mechanism is considered to be that Pd(0) first undergoes oxidative addition reaction with halogenated aromatic hydrocarbons to generate Pd(lI) complexes, then undergoes ligand exchange, and finally undergoes reduction and elimination reactions to obtain coupling products, and at the same time regenerates to obtain Pd (0), complete the catalytic cycle process. It is one of the most important and influential chemical reactions discovered in the 20th century. This reaction has greatly promoted the development of organic synthetic chemistry, and has become the most effective and convenient way to sy...

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Problems solved by technology

In previous reports, there are few examples of cyclodextrin-based supramolecular nanoassemblies used in the field of organocatalysis

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