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Nanocomposite particles and preparation method thereof

A nanocomposite and nanoparticle technology, applied in the field of materials science, can solve the problems of poor water solubility of porphyrin molecules, low PDT effect, easy agglomeration, etc., and achieve good photothermal effect, good photothermal effect, and good dispersion.

Inactive Publication Date: 2019-07-19
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the water solubility of porphyrin molecules is poor, and they are easy to agglomerate and cause quenching, so the effect of simple porphyrin molecules for PDT is low.

Method used

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  • Nanocomposite particles and preparation method thereof
  • Nanocomposite particles and preparation method thereof
  • Nanocomposite particles and preparation method thereof

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preparation example Construction

[0036] The preparation method of the nanocomposite particles provided by the invention is as follows:

[0037]Step one, ZrCl 4 Soluble in N,N-dimethylformamide to form ZrCl 4 solution, then in ZrCl 4 Terephthalic acid, benzoic acid, hydrochloric acid and meso-tetrakis(4-carboxyphenyl)porphine were sequentially added into the solution to obtain a green solution after dissolution;

[0038] Step 2, transfer the green solution to a hydrothermal kettle, react at 100-150°C for 12-48 hours, then cool at room temperature to obtain the first suspension;

[0039] Step 3, centrifuging the first suspension to obtain a purple precipitate, washing the purple precipitate with the first solvent, and vacuum-drying the cleaned purple precipitate to obtain the embedded medium-tetrakis (4-carboxyphenyl) porphyrin phenometallic organic framework nanoparticles;

[0040] Step 4, adding metal-organic framework nanoparticles to a buffer solution with pH>7, then adding a predetermined amount of dop...

Embodiment 1

[0043] Embodiment 1 is the preparation experiment of the nanocomposite particle of the present invention, comprises the following steps:

[0044] Step 1, 0.3mmol ZrCl 4 Dissolve in 6ml N,N-dimethylformamide to form ZrCl 4 solution, then in ZrCl 4 Add 0.3mmol terephthalic acid, 5mmol benzoic acid, 1.5mmol hydrochloric acid and 0.015mmol meso-tetrakis(4-carboxyphenyl)porphine (TCPP) to the solution in sequence, and sonicate for 10min until completely dissolved, and a green solution is obtained after dissolution.

[0045] Step 2: transfer the green solution to a hydrothermal kettle (polytetrafluoroethylene lined, stainless steel kettle body), perform solvothermal reaction at 120° C. for 24 hours, and then cool to room temperature to obtain the first suspension.

[0046] Step 3: Centrifuge the first suspension at 10,000 rpm to obtain a purple precipitate, wash the purple precipitate with N,N-dimethylformamide, ethanol, and deionized water three times, and then place the purple p...

Embodiment 2

[0068]Embodiment 2 is the preparation experiment of the nanocomposite particle of the present invention, comprises the following steps:

[0069] Step 1, 0.3mmol ZrCl 4 Dissolve in 6ml N,N-dimethylformamide to form ZrCl 4 solution, then in ZrCl 4 Add 0.3mmol terephthalic acid, 9mmol benzoic acid, 1.5mmol hydrochloric acid and 0.015mmol meso-tetrakis(4-carboxyphenyl)porphine (TCPP) successively to the solution, and ultrasonically for 10min until it is completely dissolved, and a green solution is obtained after dissolution.

[0070] Step 2: transfer the green solution to a hydrothermal kettle (polytetrafluoroethylene lined, stainless steel kettle body), perform solvothermal reaction at 130° C. for 12 hours, and then cool to room temperature to obtain the first suspension.

[0071] Step 3, centrifuge the first suspension at 8000rpm to obtain a purple precipitate, wash the purple precipitate with ethanol three times, and then place the purple precipitate in a vacuum drying oven ...

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Abstract

The invention provides nanocomposite particles and a preparation method thereof. The preparation method of the nanocomposite particles comprises the following steps: dissolving ZrCl4 in N,N-dimethylmethylamide so as to form a ZrCl4 solution; sequentially adding terephthalic acid, benzoic acid, hydrochloric acid and meso-tetra(4-carboxyphenyl)porphine into the ZrCl4 solution so as to obtain organometallic framework nanoparticles embedded with porphyrin molecules; adding the organometallic framework nanoparticles into a buffer solution; and then, adding dopamine so as to form polydopamine by polymerization of dopamine molecules, thereby wrapping outer surface of the organometallic framework nanoparticles with the polydopamine so as to form nanocomposite particles with a core-shell structure,wherein thickness of the polydopamine layers is 5-50nm and size of the nanocomposite particles is 60-500nm. The nanocomposite particles prepared by the preparation method are uniform in appearance, good in dispersivity, low in biological toxicity, and excellent in photothermal effects and photodynamic therapeutic effects; and thus, the nanocomposite particles have good curative effects on tumors.

Description

technical field [0001] The invention belongs to the field of materials science, and in particular relates to a nanocomposite particle and a preparation method thereof. Background technique [0002] Cancer has become a major threat to human health. The traditional treatment methods for cancer include chemotherapy, radiotherapy and surgery, etc., but these treatment methods have various defects and deficiencies. With the development of science and technology, photothermal therapy (PTT) based on nanocarriers has unique advantages as a minimal non-invasive treatment method. Photothermal agents of PTT, such as noble metals, organic polymers, carbon-based nanomaterials, and semiconductor compounds, can absorb light and convert it into heat energy, which can increase the local temperature and selectively kill target tumor cells. Organic polymer photothermal agents have received extensive attention due to their good biocompatibility and low biotoxicity. One of the organic polymer ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/34A61K47/22A61K41/00A61P35/00
CPCA61K9/5123A61K9/5146A61K41/0052A61K41/0071A61P35/00A61K2300/00
Inventor 朱钰方陈佳杰
Owner UNIV OF SHANGHAI FOR SCI & TECH
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