30results about How to "Reduce positive charge" patented technology

Apparatus is provided including an assembly (22) and a control unit (36). The assembly (22) includes a housing (34) configured to be applied to a nerve (20) of a subject, and at least one cathode (30) and at least one Peltier cooler (32), which are fixed to the housing (34). The control unit (36) is configured to drive the cathode (30) to apply an activating current to the nerve (20) that generates action potentials traveling in first and second directions (38 and 40) in the nerve (20), and the Peltier cooler (32) to cool the nerve (20) sufficiently to block propagation of at least a portion of the cathode-generated action potentials traveling in the second direction (40). Other embodiments are also described.

The invention discloses a combined filter membrane for efficient filtration of leukocyte, a manufacturing method thereof and a leukocyte filter. The combined filter membrane is manufactured by clamping a fiberglass layer between two polyester fiber non-woven cloth layers, and is coated with acrylic acid type copolymer to make combination of two different types of fibers solider, the hydrophilic properties of the combined filter membrane can be maintained after high-temperature steam sterilization, uniform copolymer coated on the fiberglass surface can be molten and contracted to be distributed like a pearl during high-temperature sterilization, the glass body can be exposed, the surface of the glass body contains positive charges, leukocyte contains negative charges, and the capacity of the combined filter membrane to filter leukocyte can be significantly improved due to mutual attraction of the positive charges and the negative charges. The combined filter membrane is used as a fine filter membrane to replace part of polyester non-woven cloth and is taken as a filter medium and arranged in the leukocyte filter, the comprehensive online filtration can be realized, and the rate of leukocyte filtration exceeds 99.99 percent.

The invention discloses a pH response type lipid based on dendrimers as well as a preparation method and application of the pH response type lipid, and belongs to the field of biological materials. The pH response type lipid disclosed by the invention has different surface charges under different pH environments. The specific forms are that negative electricity, neutrality or micro positive electricity are shown in an in vivo physiological environment to ensure that the pH response type lipid can have good biocompatibility, and amino groups are gradually exposed to expose more positive charges or realize charge reversal by using the pH differences between tumor tissues and normal tissues or between the inside and outside of tumor cells when the pH response type lipid reaches tumor tissue places, so that the contact between a positive electric carrier and a negative electric cell membrane is finished, and then the process of cell endocytosis is promoted. In a cytolysosome, a cationic vector continuously gives play to proton sponge effect or lysosome membrane splitting action so as to escape from lysosome.

A period (inverted period) in which a high negative potential is applied to a gate of the transistor is provided between a writing period and a retention period. In the inverted period, supply of positive electric charge from the drain of the transistor to the oxide semiconductor layer is promoted. Thus, accumulation of positive electric charge in the oxide semiconductor layer or at the interface between the oxide semiconductor layer and a gate insulating film can converge in a short time. Therefore, it is possible to suppress a decrease in the positive electric charge in the node electrically connected to the drain of the transistor in the retention period after the inverted period. That is, the temporal change of data stored in the semiconductor device can be suppressed.

The invention relates to a flocculant, in particular to a paper sludge dewatering composite flocculant. The flocculant provided by the invention consists of an inorganic flocculant, an organic flocculant, a biological flocculant, a surfactant, an activating agent and an agglomeration solution. According to the paper sludge dewatering composite flocculant provided by the invention, the dehydration property of the paper sludge can be improved, the activity of the paper sludge can be improved, the agglomerate property of the paper sludge can be improved, and the cost can be reduced.

The present invention mainly relates to a nuclear radiation detector, in particular, it relates to a position sensitive detector used in the high-energy physics and nuclear physics and its production process. Said detector includes silicon substrate, N-type, it is mainly characterized by that it also includes detection window, it is formed from mutually-parallelized detection windows, it has B+ doped region, forming PN Gunction, on it an Al-layer is set, and is equipped with a lead; between two windows an insulated separating zone is set; back surface of silicon substrate has P- doped region, forming N+ ohmic contact, on it an Al-layer is coated to form back electrode. Said invention also provides the concrete steps of its production method.

The invention belongs to the technical field of medicines and specifically provides a folic acid modified chitosan quaternary ammonium salt-taxol polymer medicine, as well as a preparation method and an application of the polymer medicine. The polymer medicine provided by the invention is formed by connecting taxol to chitosan quaternary ammonium salt in the form of covalent linkage by succinyl ester and connecting tumor target ligand folic acid. The preparation method comprises the following steps of: connecting succinic anhydride open loop with taxol to synthesize succinyl taxol, modifying chitosan by quaternization to obtain chitosan quaternary ammonium salt; and under the action of a catalyst, connecting succinyl taxol to chitosan quaternary ammonium salt in the form of covalent linkage, and introducing target ligand folic acid. The polymer medicine can be assembled automatically in water to form nanoparticles, wherein hydrophobic medicine is used as the inner core and chitosan quaternary ammonium salt is used as a hydrophilic shell. The polymer medicine is simple in preparation method, excellent in repeatability and security, and can enhance the targeting and tumor inhibiting effect of taxol by two administration routes consisting of oral taking and intravenous injection.

A flat-panel display is fabricated by a process in which a spacer (24) having a rough face (54 or 56) is positioned between a pair of plate structure (20 and 22). When electrons strike the spacer, the roughness in the spacer's face causes the number of secondary electrons that escape the spacer to be reduced, thereby alleviating positive charge buildup on the spacer. As a result, the image produced by the display is improved. The spacer facial roughness can be achieved in various ways such as providing suitable depressions (60, 62, 64, 66, 70, 74, or 80) or / and protuberances (82, 84, 88, and 92) along the spacer's face.

The invention discloses a producing method for a P-trench VDMOS device. The method comprises: an oxidation layer grows on an epitaxial layer, a photoresist layer covers the oxidation layer, and adhesive-included N type impurity injection is carried out; a needed N type base region junction depth is formed in the upper surface of the epitaxial layer after high-temperature annealing; boron impurity injection is carried out on the oxidation layer; a gate oxide layer grows on the epitaxial layer, polysilicon deposition and doping are carried out on the gate oxide layer, a polysilicon gate layer is formed by using a polysilicon gate photoetching panel; a photoresist covers a local area of the gate oxide layer, source P+ processing is carried out directly, and then a P+ region is formed in the N type base region; and then an inner metal insulating layer is deposited and metal layer are arranged on the upper surface and the lower surface of the epitaxial layer to form a standard VDMOS device. According to the method, the Vth value of the P-trench VDMOS device can be stabilized between 2 to 4V; and the stability and reasonability are high.

In the plasma etching process of the integrated circuit, a portion of the charges from the plasma accumulates on the semiconductor device through the conductive portion of the integrated circuit so as to damage the device. The phenomenon mentioned above is so called antenna effect. In order to decreased the number of the accumulated charges caused by antenna effect and to alleviate the damage of the accumulated charges on the device, the conductive photoresist is used in the plasma etching process. The method for applying the conductive photoresist in the integrated circuit process is as same as the application method for using the well known standard photoresist.

The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof:wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.

The invention belongs to the technical field of biological medicines, and relates to a D type IF-7 polypeptide-modified reductive dendrimer-like macromolecule (RHB) self-assembled double-targeted nucleic acid transfer and release system and a preparation method thereof. The preparation method comprises the following steps of automatically compressing plasmid DNA (deoxyribonucleic acid) by reductive dendrimer-like cationic polymer polyamino ammonia (RHB), so as to form a binary complex; using an inverted sequence D type technique to transform an IF7 peptide of a targeted tumor blood vessel endothelial cell surface specificity receptor Anxal, and synthesizing RIF7 polypeptide; performing amidation reaction to combine the RIF7 polypeptide onto an HA molecular structure of a CD44 receptor on the surface of a targeted tumor cell, and synthesizing a double-targeted coating material; under the electrostatic action, coating the formed RHB / DNA binary complex, so as to form a targeted ternary complex nucleic acid transfer and release system. The preparation method has the advantages that the transfer and release system can effectively compress and coat the plasmid DNA; by utilizing the double-targeted action, the complex can cross tumor blood vessel barriers and tumor cytomembrane barriers step by step, the transfection efficiency of a gene is improved, and the toxicity of a carrier system is decreased.

The invention relates to a freshness-preserving method and equipment, and in particular relates to a biological enzyme active freshness-preserving device and a method thereof. Combined with an alternating-current field and low-frequency vibration, the bonding state of internal water molecules of objects preserved in a large electric field space and enzyme activity are changed, thereby achieving the effects of inhibiting bacteria growth and protecting cell tissues; and for eliminating surplus positive charges, a negative ion generating device or a special rare earth mixed material is also utilized for generating negative ions, thereby achieving a neutralizing effect. A photocatalyst in the biological enzyme active freshness-preserving device can effectively decompose ethylene and other organic gas under photocatalysis and simultaneity kill bacteria and viruses in air. The biological enzyme active freshness-preserving device can effectively prolong the freshness-preserving period of green vegetables, fruits, meat and seafood, can change the water crystallization behavior to generate fine and smooth ice crystals to play a protective role on cells, and can be applied to each link of a cold chain for improving the freshness-preserving and freezing quality and decreasing the wastage rate.

The invention discloses a natural dye dyeing method. The natural dye dyeing method comprises the following steps: step 1) dyeing fabrics by adopting natural dyes, wherein the use amount of the naturaldyes is 0.5-5% (o. m. f), and the bath ratio is 1: 20-40, and the dyeing temperature is 50-80 DEG C; and naturally airing for later use after dyeing is finished; step 2) dissolving a mordant in deionized water, adjusting the pH value to be 3-4, adding a neutral electrolyte, and completely dissolving; step 3) immersing the dyed fabric in the step 1) into a mordant bath, wherein the bath ratio is 1: 5-1: 8; after treating the dyed fabric at the mordant dyeing temperature of 20-25 DEG C for 45-90 min, adding deionized water to dilute until the bath ratio is 1: 30-1: 40; and then heating to the temperature of 50-60 DEG C, treating the fabric, rinsing the fabric with a 0.5% oxalic acid solution, washing the fabric with water, and naturally airing the fabric. Mordant treatment is carried out atlow alkalinity, lower temperature and pH, and in the later period of mordant treatment, by means of increasing pH, heating, adding water for dilution and the like, hydrolysis and polymerization of hydrated metal ions are increased, molecules of a metal complex are enlarged, combination of the metal complex with natural dyes and fibers is promoted, and dyeing fastness of the natural dyes is improved.

The invention belongs to the technical field of biomedical materials and particularly relates to a gelatin-polylactic acid grafted amphipathic copolymer nano-micelle material and a preparation method of the material. A copolymer nano-micelle is formed by self-assembly of hydrophilic gelatin and hydrophobic polylactic acid grafted materials. The preparation method comprises the steps of dissolving purified gelatin in anhydrous dimethyl sulfoxide, adding monomers such as lactide and a stannous octoate catalyst for heating reaction under the shield of nitrogen to form a gelatin grafted polylactic acid copolymer, and dissolving the polymer in water to form the nano-micelle. The prepared material can form the uniform and stable micelle in the water; the micelle is 100-500nm in particle size; the surface of the micelle is positively charged; when a concentration of the micelle in blood is 0.1-5mg.mL<-1>, blood coagulation can be accomplished within 2-5min; and the material can serve as a blood coagulation material with excellent performance and also has broad application prospects in antibacterial spray and entrapment drugs.

The present invention mainly relates to a nuclear radiation detector, in particular, it relates to a position sensitive detector used in the high-energy physics and nuclear physics and its production process. Said detector includes silicon substrate, N-type, it is mainly characterized by that it also includes detection window, it is formed from mutually-parallelized detection windows, it has B+ doped region, forming PN Gunction, on it an Al-layer is set, and is equipped with a lead; between two windows an insulated separating zone is set; back surface of silicon substrate has P- doped region, forming N+ ohmic contact, on it an Al-layer is coated to form back electrode. Said invention also provides the concrete steps of its production method.

The present invention is to provide a member for reducing charge for transportation that further decreases positive charge of charged transportation to contribute to improvement in driving stability and acceleration performance. The member for reducing charge for transportation 1 of the present invention is a laminated structure in which a metal layer 11 and a radiation generating layer 12 are laminated. The metal layer 11 contains a metal with a redox potential of 0 V or less or an alloy of a metal with a redox potential of 0 V or less, and the radiation generating layer 12 contains a mixture of a natural ore containing a radioactive substance with a radiolucent resin. The dose of radiation generated from the radiation generating layer 12 is from 0.02 μSv / h or more to 0.2 μSv / h or less. The member 1 is suitably used for the transportation in which the body is positively charged by static electricity caused by travelling, cruising, etc.

The invention provides a production method of tobacco liposome modified by polyethylene glycol-poly(beta-amino ester). The production method of the tobacco liposome modified by polyethylene glycol-poly(beta-amino ester) comprises the following steps that methoxy polyethylene glycol is added into tetrahydrofuran, stirring to dissolve at low temperature is carried out, acrylamide chloride is added,and heating reaction is carried out to obtain polyethylene glycol modified by the acrylamide chloride; tobacco volatile oil, phospholipid and cholesterol are added to the ethanol and transferred to asupercritical carbon dioxide fluid reactor, carbon dioxide is added to replace the ethanol, polyethylene glycol modified by the acrylamide chloride is added, phosphoric acid regulating system PH valueis added, stirring is carried out, supercritical carbon dioxide is pressed and heated to precipitated, pressure is released quickly, the tobacco liposome modified by polyethylene glycol which is modified by the acrylamide chloride is obtained; the tobacco liposome modified by polyethylene glycol which is modified by the acrylamide chloride, 1,4-butanediol diacrylate and 1-amino-3-propanol is added to trichloromethane, ultrasonic dispersion, microwave reaction, precipitation filtration and drying are carried out, and the tobacco liposome modified by polyethylene glycol-poly(beta-amino ester) is obtained.

The present invention is to provide apparatus for reducing charge for vehicle that is capable to decrease the charge taken by a vehicle regardless of the type of the drive source, which is more reasonable without relying on external energy supplied from, for example, a battery carried in a vehicle and which enables its small size. The apparatus for reducing charge for vehicle 1 of the present invention includes a body 10 and a conductive wire 20 that extends from this body 10. The body 10 includes a radiation generating layer 11 containing a natural ore containing a radioactive substance, a first metal layer 12 containing a metal with a redox potential of 0 V or less or an alloy of this metal, and a second metal layer 13 containing a metal with a volume electric resistance rate of 4.7 μΩ·cm or less at 0° C. or an alloy of this metal. The conductive wire 20 extends from the second metal layer 13 and is connected with at least one of predetermined electrically connective connections in a vehicle including a minus terminal of a battery provided in the vehicle.

The invention relates to a docetaxel derivative, and a preparation method and application thereof, belonging to the technical field of medicine. The docetaxel derivative provided by the invention is triphenyl phosphine-docetaxel (TD) and is prepared by subjecting docetaxel and 4-carboxybutyltriphenylphosphonium bromide to an esterification reaction under the catalysis of EDC and DMAP. Docetaxel and a mitochondrion-targeted group triphenylphosphine are connected via an ester bond; and the structure of the docetaxel derivative is as shown in the specification. The docetaxel derivative provided by the invention is simple and practicable to synthesize and provides a novel idea for mitochondrion-targeted drug delivery. The docetaxel derivative is entrapped in liposome; the preparation method issimple and practicable and has good reproducibility and high stability; and the PEG-modified liposome of the docetaxel derivative is increased in circulation time in blood and can better release antitumor drugs at tumor sites due to a pH-sensitive fracture mechanism.

The invention discloses a production method of a P-channel VDMOS device, which includes forming an oxide layer on the epitaxial layer, covering the oxide layer with a photoresist layer, and then injecting N-type impurities with glue; The required N-type base junction depth step; the boron impurity implantation step on the oxide layer; the gate oxide layer is formed on the epitaxial layer, and then polysilicon deposition and doping are performed on the gate oxide layer, and the polysilicon gate is used again Step of forming a polysilicon gate layer with a photolithography plate; covering a local area of ​​the gate oxide layer with photoresist, then directly performing source P+ processing, and forming a P+ region in the N-type base region; and finally depositing an inner metal insulating layer, and at the same time The upper surface and the lower surface of the epitaxial layer are respectively provided with a metal layer to form a standard VDMOS device step. The production method of the above-mentioned P-channel VDMOS device can stabilize the Vth value of the P-channel VDMOS device between 2 and 4V, which has extremely high stability and rationality.

The preparation and application of a compound denatured gluten powder of damp heat and acylation belongs to the technical field of denatured protein. In the invention, the raw material gluten is modified by moist heat and acylation to obtain compound denatured gluten, and the product prepared by the method of the invention has many excellent characteristics such as good emulsification and foaming. The products are mainly used as additives in grain industry, food industry and feed industry to improve the quality of flour and used in the production of bread, noodles and instant noodles. The invention has the advantages of organically combining two kinds of denaturation methods of damp heat and acylation to carry out physical and chemical modification of gluten powder, scientific and practical process design, and excellent product performance.

The invention relates to a flocculant, in particular to a paper sludge dewatering composite flocculant. The flocculant provided by the invention consists of an inorganic flocculant, an organic flocculant, a biological flocculant, a surfactant, an activating agent and an agglomeration solution. According to the paper sludge dewatering composite flocculant provided by the invention, the dehydration property of the paper sludge can be improved, the activity of the paper sludge can be improved, the agglomerate property of the paper sludge can be improved, and the cost can be reduced.

The invention discloses a dendrimer-based pH-responsive lipid, a preparation method and application thereof, and belongs to the field of biological materials. The pH-responsive lipids involved in the present invention have different surface charges in different pH environments. The specific performance is that it presents negative, neutral or slightly positive electricity in the physiological environment in vivo, so that it can have good biocompatibility, and when it reaches the tumor tissue, it can utilize the pH difference between tumor tissue and normal tissue or inside and outside tumor cells. , the amino group is gradually exposed to expose more positive charges or realize charge reversal, and complete the contact between the positively charged carrier and the negatively charged cell membrane, thereby promoting the process of cell endocytosis. In cell lysosomes, cationic carriers continue to function as proton sponges or lysosomal membrane cleavage to escape from lysosomes.

The invention discloses a combined filter membrane for efficient filtration of leukocyte, a manufacturing method thereof and a leukocyte filter. The combined filter membrane is manufactured by clamping a fiberglass layer between two polyester fiber non-woven cloth layers, and is coated with acrylic acid type copolymer to make combination of two different types of fibers solider, the hydrophilic properties of the combined filter membrane can be maintained after high-temperature steam sterilization, uniform copolymer coated on the fiberglass surface can be molten and contracted to be distributed like a pearl during high-temperature sterilization, the glass body can be exposed, the surface of the glass body contains positive charges, leukocyte contains negative charges, and the capacity of the combined filter membrane to filter leukocyte can be significantly improved due to mutual attraction of the positive charges and the negative charges. The combined filter membrane is used as a fine filter membrane to replace part of polyester non-woven cloth and is taken as a filter medium and arranged in the leukocyte filter, the comprehensive online filtration can be realized, and the rate of leukocyte filtration exceeds 99.99 percent.

The invention belongs to the technical field of biological medicines, and relates to a D type IF-7 polypeptide-modified reductive dendrimer-like macromolecule (RHB) self-assembled double-targeted nucleic acid transfer and release system and a preparation method thereof. The preparation method comprises the following steps of automatically compressing plasmid DNA (deoxyribonucleic acid) by reductive dendrimer-like cationic polymer polyamino ammonia (RHB), so as to form a binary complex; using an inverted sequence D type technique to transform an IF7 peptide of a targeted tumor blood vessel endothelial cell surface specificity receptor Anxal, and synthesizing RIF7 polypeptide; performing amidation reaction to combine the RIF7 polypeptide onto an HA molecular structure of a CD44 receptor on the surface of a targeted tumor cell, and synthesizing a double-targeted coating material; under the electrostatic action, coating the formed RHB / DNA binary complex, so as to form a targeted ternary complex nucleic acid transfer and release system. The preparation method has the advantages that the transfer and release system can effectively compress and coat the plasmid DNA; by utilizing the double-targeted action, the complex can cross tumor blood vessel barriers and tumor cytomembrane barriers step by step, the transfection efficiency of a gene is improved, and the toxicity of a carrier system is decreased.