30results about How to "Reduce positive charge" patented technology

We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.

A flat-panel display is fabricated by a process in which a spacer (24) having a rough face (54 or 56) is positioned between a pair of plate structure (20 and 22). When electrons strike the spacer, the roughness in the spacer's face causes the number of secondary electrons that escape the spacer to be reduced, thereby alleviating positive charge buildup on the spacer. As a result, the image produced by the display is improved. The spacer facial roughness can be achieved in various ways such as providing suitable depressions (60, 62, 64, 66, 70, 74, or 80) or / and protuberances (82, 84, 88, and 92) along the spacer's face.

A period (inverted period) in which a high negative potential is applied to a gate of the transistor is provided between a writing period and a retention period. In the inverted period, supply of positive electric charge from the drain of the transistor to the oxide semiconductor layer is promoted. Thus, accumulation of positive electric charge in the oxide semiconductor layer or at the interface between the oxide semiconductor layer and a gate insulating film can converge in a short time. Therefore, it is possible to suppress a decrease in the positive electric charge in the node electrically connected to the drain of the transistor in the retention period after the inverted period. That is, the temporal change of data stored in the semiconductor device can be suppressed.

The invention belongs to the technical field of biological medicines, and relates to a D type IF-7 polypeptide-modified reductive dendrimer-like macromolecule (RHB) self-assembled double-targeted nucleic acid transfer and release system and a preparation method thereof. The preparation method comprises the following steps of automatically compressing plasmid DNA (deoxyribonucleic acid) by reductive dendrimer-like cationic polymer polyamino ammonia (RHB), so as to form a binary complex; using an inverted sequence D type technique to transform an IF7 peptide of a targeted tumor blood vessel endothelial cell surface specificity receptor Anxal, and synthesizing RIF7 polypeptide; performing amidation reaction to combine the RIF7 polypeptide onto an HA molecular structure of a CD44 receptor on the surface of a targeted tumor cell, and synthesizing a double-targeted coating material; under the electrostatic action, coating the formed RHB / DNA binary complex, so as to form a targeted ternary complex nucleic acid transfer and release system. The preparation method has the advantages that the transfer and release system can effectively compress and coat the plasmid DNA; by utilizing the double-targeted action, the complex can cross tumor blood vessel barriers and tumor cytomembrane barriers step by step, the transfection efficiency of a gene is improved, and the toxicity of a carrier system is decreased.

The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof:wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.

The present invention mainly relates to a nuclear radiation detector, in particular, it relates to a position sensitive detector used in the high-energy physics and nuclear physics and its production process. Said detector includes silicon substrate, N-type, it is mainly characterized by that it also includes detection window, it is formed from mutually-parallelized detection windows, it has B+ doped region, forming PN Gunction, on it an Al-layer is set, and is equipped with a lead; between two windows an insulated separating zone is set; back surface of silicon substrate has P- doped region, forming N+ ohmic contact, on it an Al-layer is coated to form back electrode. Said invention also provides the concrete steps of its production method.

The present invention is to provide a member for reducing charge for transportation that further decreases positive charge of charged transportation to contribute to improvement in driving stability and acceleration performance. The member for reducing charge for transportation 1 of the present invention is a laminated structure in which a metal layer 11 and a radiation generating layer 12 are laminated. The metal layer 11 contains a metal with a redox potential of 0 V or less or an alloy of a metal with a redox potential of 0 V or less, and the radiation generating layer 12 contains a mixture of a natural ore containing a radioactive substance with a radiolucent resin. The dose of radiation generated from the radiation generating layer 12 is from 0.02 μSv / h or more to 0.2 μSv / h or less. The member 1 is suitably used for the transportation in which the body is positively charged by static electricity caused by travelling, cruising, etc.

The invention discloses a production method of a P-channel VDMOS device, which includes forming an oxide layer on the epitaxial layer, covering the oxide layer with a photoresist layer, and then injecting N-type impurities with glue; The required N-type base junction depth step; the boron impurity implantation step on the oxide layer; the gate oxide layer is formed on the epitaxial layer, and then polysilicon deposition and doping are performed on the gate oxide layer, and the polysilicon gate is used again Step of forming a polysilicon gate layer with a photolithography plate; covering a local area of ​​the gate oxide layer with photoresist, then directly performing source P+ processing, and forming a P+ region in the N-type base region; and finally depositing an inner metal insulating layer, and at the same time The upper surface and the lower surface of the epitaxial layer are respectively provided with a metal layer to form a standard VDMOS device step. The production method of the above-mentioned P-channel VDMOS device can stabilize the Vth value of the P-channel VDMOS device between 2 and 4V, which has extremely high stability and rationality.

The preparation and application of a compound denatured gluten powder of damp heat and acylation belongs to the technical field of denatured protein. In the invention, the raw material gluten is modified by moist heat and acylation to obtain compound denatured gluten, and the product prepared by the method of the invention has many excellent characteristics such as good emulsification and foaming. The products are mainly used as additives in grain industry, food industry and feed industry to improve the quality of flour and used in the production of bread, noodles and instant noodles. The invention has the advantages of organically combining two kinds of denaturation methods of damp heat and acylation to carry out physical and chemical modification of gluten powder, scientific and practical process design, and excellent product performance.

The invention relates to a flocculant, in particular to a paper sludge dewatering composite flocculant. The flocculant provided by the invention consists of an inorganic flocculant, an organic flocculant, a biological flocculant, a surfactant, an activating agent and an agglomeration solution. According to the paper sludge dewatering composite flocculant provided by the invention, the dehydration property of the paper sludge can be improved, the activity of the paper sludge can be improved, the agglomerate property of the paper sludge can be improved, and the cost can be reduced.

The invention discloses a dendrimer-based pH-responsive lipid, a preparation method and application thereof, and belongs to the field of biological materials. The pH-responsive lipids involved in the present invention have different surface charges in different pH environments. The specific performance is that it presents negative, neutral or slightly positive electricity in the physiological environment in vivo, so that it can have good biocompatibility, and when it reaches the tumor tissue, it can utilize the pH difference between tumor tissue and normal tissue or inside and outside tumor cells. , the amino group is gradually exposed to expose more positive charges or realize charge reversal, and complete the contact between the positively charged carrier and the negatively charged cell membrane, thereby promoting the process of cell endocytosis. In cell lysosomes, cationic carriers continue to function as proton sponges or lysosomal membrane cleavage to escape from lysosomes.

The invention discloses a combined filter membrane for efficient filtration of leukocyte, a manufacturing method thereof and a leukocyte filter. The combined filter membrane is manufactured by clamping a fiberglass layer between two polyester fiber non-woven cloth layers, and is coated with acrylic acid type copolymer to make combination of two different types of fibers solider, the hydrophilic properties of the combined filter membrane can be maintained after high-temperature steam sterilization, uniform copolymer coated on the fiberglass surface can be molten and contracted to be distributed like a pearl during high-temperature sterilization, the glass body can be exposed, the surface of the glass body contains positive charges, leukocyte contains negative charges, and the capacity of the combined filter membrane to filter leukocyte can be significantly improved due to mutual attraction of the positive charges and the negative charges. The combined filter membrane is used as a fine filter membrane to replace part of polyester non-woven cloth and is taken as a filter medium and arranged in the leukocyte filter, the comprehensive online filtration can be realized, and the rate of leukocyte filtration exceeds 99.99 percent.

The invention belongs to the technical field of biological medicines, and relates to a D type IF-7 polypeptide-modified reductive dendrimer-like macromolecule (RHB) self-assembled double-targeted nucleic acid transfer and release system and a preparation method thereof. The preparation method comprises the following steps of automatically compressing plasmid DNA (deoxyribonucleic acid) by reductive dendrimer-like cationic polymer polyamino ammonia (RHB), so as to form a binary complex; using an inverted sequence D type technique to transform an IF7 peptide of a targeted tumor blood vessel endothelial cell surface specificity receptor Anxal, and synthesizing RIF7 polypeptide; performing amidation reaction to combine the RIF7 polypeptide onto an HA molecular structure of a CD44 receptor on the surface of a targeted tumor cell, and synthesizing a double-targeted coating material; under the electrostatic action, coating the formed RHB / DNA binary complex, so as to form a targeted ternary complex nucleic acid transfer and release system. The preparation method has the advantages that the transfer and release system can effectively compress and coat the plasmid DNA; by utilizing the double-targeted action, the complex can cross tumor blood vessel barriers and tumor cytomembrane barriers step by step, the transfection efficiency of a gene is improved, and the toxicity of a carrier system is decreased.

The present invention is to provide a member for reducing charge for transportation that further decreases positive charge of charged transportation to contribute to improvement in driving stability and acceleration performance. The member for reducing charge for transportation 1 of the present invention is a laminated structure in which a metal layer 11 and a radiation generating layer 12 are laminated. The metal layer 11 contains a metal with a redox potential of 0 V or less or an alloy of a metal with a redox potential of 0 V or less, and the radiation generating layer 12 contains a mixture of a natural ore containing a radioactive substance with a radiolucent resin. The dose of radiation generated from the radiation generating layer 12 is from 0.02 μSv / h or more to 0.2 μSv / h or less. The member 1 is suitably used for the transportation in which the body is positively charged by static electricity caused by travelling, cruising, etc.