38 results about "Dose selection" patented technology

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.

The label and labeling system provide a way to label containers and packaging for drug products in a manner that makes the drug readily identifiable and distinguishable for a clinician to help reduce the potential for medication errors. The study of product characteristics, usage behavior, environment and storage practices informs the design process and yields packaging and labeling that is tailored for a particular product and set of users. Information of particular importance for the clinician is emphasized through selective placement, orientation, and text size, among other characteristics. In addition, a design and color scheme may be employed to assist with proper dosage selection and reduce the potential of administering a wrong dose. Through the label and labeling system, at-a-glance accurate readability and product differentiation are enhanced.

A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose / time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a Start and end MLC position. It then controls the source in accordance with that plan over an first arc-segment such that at least one of the rotation speed and dose rate are constant and the multi-leaf collimator changes shape, and a second arc segment such that at least one of the rotation speed and dose rate are constant at a level different to the constant level adopted during the first arc-segment. It achieves this by calculating the total time required for the arc segment for a plurality of factors including an MLC leaf movement from a prescribed position at the start of the arc-segment to a prescribed position at the end of the arc-segment, at a maximum leaf speed, rotation of the source from the start to the end of the arc-segment at a maximum source rotation speed, delivery of the dose at a maximum dose rate per time, selecting the factor dictating the longest time, and Controlling the apparatus so that the selected factor operates at its respective maximum and the remaining factors are operated at a reduced rate selected to match that longest time, wherein the total time required for the arc segment for at least one factor relating to a moving geometry item is the greater of (a); a time required to complete the segment at a continuous defined upper speed for the geometry item and (b) a time required to accelerate the geometry item until it is travelling at the defined upper speed. Generally, the time required to accelerate the geometry item to the defined upper speed will include a time to accelerate the geometry item to that speed, and a further time to accelerate the geometry item beyond that speed and subsequently decelerate it until travelling at that speed.

Sample data is stored in a console of an electronic cassette (image detection panel). The sample data corresponds to a model of the electronic cassette and includes sample images captured using different doses before a shipment of the electronic cassette. In initial setting processing of an imaging condition including the dose, the sample data is read out and a dose selection screen in which the sample images are arranged is displayed on a display. In the dose selection screen, the sample images are arranged in a tiled manner in an ascending or descending order of their doses (densities). A user compares the sample images to select the sample image with the density suitable for diagnosis. The dose corresponding to the selected sample image is set as an initial value.

A injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (10) containing a primary reservoir containing a first medicament (1) and that has a secondary reservoir containing a second medicament (2) where the drug delivery device (10) has only one dose setter (12) for the primary reservoir and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface.

The invention relates to an injection dose selection mechanism, which comprises an auxiliary electronic assembly, located in a gamma-ray CT machine and comprising a camera, an optical disc memory, a work station, a display screen and a developing machine; a live scanning assembly, used for performing live gamma-ray scanning operation on a diseased portion of a patient to be examined and acquiringcorresponding gamma-ray images, wherein the camera is used for photographing the gamma-ray images output by the live scanning assembly to acquire CT electronic images, and the developing machine is connected with the camera and is used for receiving the CT electronic images and developing the CT electronic images into a CT film, and the live scanning assembly is further connected with the opticaldisk memory, the work station and the display screen; an auxiliary angiography apparatus, used for extracting a corresponding dose of a contrast medium from a contrast medium storage container according to a received reference injection dose; and dose selection equipment, used for determining the corresponding reference injection dose according to a received age. Due to the injection dose selection mechanism, the injection dose of the contrast medium can be automatically selected.

The invention discloses an afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method comprises calculating all positions of stationary points on a source applicator and activating stationary points within a tumor target region; calculating the number of dose selection reference points in each image; and working out the optimal stationary point position and residence time through an internal-external double circulation mode. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation system comprises an image generation unit, a stationary point activation unit, a statistics unit and a circulation calculation unit. According to the invention, a customized anatomical structure is taken as the basis, the optimal combination mode of the radioactive source residence position and residence time is obtained by means of an internal-external double circulation searching mode, the customized afterloading radiotherapy dose inverse intensity-modulated optimizing demand can be satisfied, in the external circulation, a primary combination is solved by means of a relaxation method, in the internal circulation, by combining the expected dose of the tumor target region and the constraint dose which is dangerous to organs, the gradient of the stationary point position and the residence time is further optimized. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system can be widely applied to afterloading radiotherapy dose calculation.

An injection device comprises a housing, a dose indicator positioned within the housing and a dose selector operatively connectable to the dose indicator. The dose selector and the dose indicator are capable of cooperating with one another to set a dose to be ejected from the injection device. The dose indicator comprises an odometer including: i. a units (218) wheel operatively connected to the dose selector so that rotation of the dose selector also rotates the units wheel, and ii. a tens wheel (219) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. The dose indicator further comprises an axially-moveable shuttle lock (222) rotationally locked to the tens wheel and selectively engageable with the units wheel and the housing. The tens wheel is selectively engageable with the units wheel via said shuttle lock and, when the tens wheel is not engaged with the units wheel, the shuttle lock is rotationally locked to the housing.

There is provided an injection device for delivering a medicament from a container. The device comprises, a housing for housing a container, a plunger substantially housed within the housing and whichis movable within the housing, a force applicator for applying a force to the plunger, a trigger (5) coupled to the force applicator for releasing the force applicator to fire the device, a boot (2),a dose selector (4) for allowing a user to select a dose of medicament, and a first mechanical interlock arranged such that the force applicator cannot be released until the dose selector has been operated to select the dose of medicament, and a second mechanical interlock arranged such that the dose selector cannot be operated to select the dose of medicament prior to removal of the boot.

An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).

A microtablet dispenser is provided herein including: a microtablet reservoir disc including a plurality of wells each formed to accommodate at least one microtablet, the wells being arranged in at least one array; a screen plate having at least one opening shaped to expose all of the wells of one of the arrays when aligned therewith; and, a dose selector plate including a plurality of dosing apertures arranged in a plurality of dosing arrays of different patterns. With one of the arrays being aligned with the at least one opening of the screen plate and with a selected dosing array, the microtablets accommodated in the wells aligned with dosing apertures are free to pass through the corresponding dosing apertures so as to be dispensed therefrom, while the wells of the array not aligned with dosing apertures are obstructed by solid portions of the dose selector plate.

An injection device incorporating a dose setting mechanism that contains a dose selector having a fail safe feature that activates during an interrupted dose delivery event where a projecting rib engages a protrusion on a snap element to prevent the dose knob from moving distally when a user removes an axial force in the proximal direction during dose delivery, intermediate stops to assist the user in dialing a dose and an injection feedback mechanism.

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.

An injection device incorporating a dose setting mechanism is presented where the dose setting mechanism contains a dose selector having one or more dose stops corresponding to a finite set of predetermined fixed doses, where the set of finite predetermined fixed doses includes a lowest fixed dose and one or more higher fixed doses, and where at least one of the one or more higher fixed doses is equal to the lowest fixed dose plus a fractional amount of the lowest fixed dose. The dose setting mechanism can further include a floating spline that is rotationally engaged with a snap element such that the snap element can rotate relative to the floating spline during both dose setting and dose delivery.

The invention relates to an image analysis system based on shape detection, and the system comprises: a dose selection mechanism, which is used for determining the corresponding current infusion dose based on the received on-site bottle body volume; a juice brewing driving mechanism, which is used for driving the juice brewing faucet to execute on-site juice brewing operation of the corresponding dosage according to the received current juice brewing dosage; and a juice brewing faucet, which is used for executing the operation of brewing the juice into a new vacant juice bottle body under the driving of the juice brewing driving mechanism when the lower assembly line pushes the new vacant juice bottle body. The invention further relates to an image analysis method based on shape detection. The image analysis system and method based on shape detection are compact in design and reliable in compatibility. The volume of the newest vacant juice bottle body pushed by the assembly line can be analyzed by adopting a targeted image analysis mechanism, and intelligent juice brewing treatment of different doses is realized based on the analysis result, so that waste of hardware resources of juice processing is avoided.

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having an opening, a dose selector operable to set a dose by rotation relative to the housing, a release member controlling movement of a piston in a dispensing direction, and a display comprising a units number wheel and a tens number wheel which are coupled to each other such that a continuous rotation of the units number wheel is translated into an intermittent rotary motion of the tens number wheel. The release member rotates, during dose dispensing, an angle corresponding to the dose set by the dose selector, thereby allowing a piston to move in a dispensing direction.

A dose setting mechanism (102) having a locking mechanism (200, 300, 400) for preventing dose selection of a drug in a drug delivery device (100) is disclosed. The dose setting mechanism (102) includes a locking mechanism (200, 300, 400) preventing movement of the dose setting mechanism (102). When the correct cartridge (120) is inserted into the drug delivery device (100), the locking mechanism (200, 300, 400) is unlocked allowing movement of the dose setting mechanism (102). In one arrangement, the locking mechanism (200, 300, 400) prevents rotation of the dose setting mechanism (102).

An injection pen comprises a cartridge 2, a dose selector housing 10 and a nut 18 for coupling the two housings 2, 10 together. The dose selector housing 10 defines an intermediate axial position in which the nut 18 may be temporarily retained in the dose selector housing 10 to form a subassembly suitable for transport to different positions. During the final assembly of the injection pen, the cartridge 2 is securely engaged with the nut 18 and moves the nut 18 from the intermediate axial position to the final axial position.

An injection device comprises a housing having a longitudinal axis, an axially-depressible dose button (430), a dose indicator (418), a dose setting mechanism operatively coupled to said dose indicator and capable of setting a dose to be ejected from the injection device and spring capable of storing energy necessary for ejecting the dose from the injection device. The spring (420) is coupled to the dose setting mechanism such that a charging force can be transferred from the dose setting mechanism to the spring to increase the energy stored by the spring. The dose setting mechanism comprises an assembly of three components, including: •a ratchet ring (410) rotationally and axially locked with respect to said housing, the ratchet ring including a ratchet component; •a drive plate (405) including a first set of splines forming a ratchet arrangement with said ratchet component; and•a dose selector (416) capable of being rotated about said longitudinal axis with respect to said housing to set the dose and including splines for disengaging said ratchet arrangement. The ratchet component is capable of interacting with both the splines on the dose selector and the splines on the drive plate.

The present invention relates generally to drug delivery devices for selecting and dispensing several user variable doses of medicaments. The device comprises a housing (10), a dose selector (80) operable by rotation relative to the housing (10) to set a dose, a number sleeve arranged within the housing (10) and carrying a dose scale (60), a drive sleeve (40), rotationally constrained to the housing (10) during dose setting and dose correction and rotatable relative to the housing (10) during dose dispensing, coupled to the housing ( 10) and coupled to the piston rod (30) of the drive sleeve (40), the drive spring (90) arranged between the housing (10) and the number sleeve (60) and deformed during dose setting on the turn ) and a bi-directional ratchet mechanism (43, 64) operatively arranged between the drive sleeve (40) and the number sleeve (60), the ratchet mechanism (43, 64) allows the dose selector and the number sleeve to move along both sides. Rotate in two directions to respectively set or correct the dose to be injected and include at least one clicker arm (43) on one of the number sleeve (60) and drive sleeve (40) acting radially On the other of the number sleeve (60) and drive sleeve (40).

A drug delivery device comprising: a body and a movable component arranged inside the body; a dosage selection and injection mechanism setting the position of the movable component inside the body depending on a selected dosage; a non-contact sensor configured to output signals indicative of the position of the movable component inside the body; and a processor configured to receive the signals output from the non-contact sensor and to determine based on the signals whether the movable component is either in an initial position inside the body corresponding to no selected dosage or in a selected dosage position, wherein upon determining that the movable component has changed its position back from the selected dosage position to the initial position, the processor is configured to cause anindication to be output which informs a user regarding a dwell time of the drug delivery device.

The present invention generally relates to a drug delivery device for selecting and dispensing multiple doses of a medicament. The drug delivery device comprises: a medicament reservoir attached to a housing (10; 10'; 10'); a drive mechanism (30, 40) comprising a plunger (30; 30'), the plunger (30; 30') axially movable relative to the housing (10; 10'; 10') to dispense a dose of medicament from the medicament reservoir; a dose selection element (60, 80; 60') which is releasably coupled to the drive mechanism and Rotatable relative to the housing (10; 10'; 10') in a first direction for dose selection; trigger (70; 70') axially movable relative to the housing (10; 10'; 10') To start dispensing the dose selected by the dose selection element (60, 80; 60'); and a limiter (100; 100'; 100"; 100') which selectively allows and prevents the trigger according to the amount of the selected dose Axial movement of (70; 70'). Restrictor (100; 100'; 100"; 100') is rotationally constrained to dose selection element (60, 80; 60') and axially constrained to trigger (70 ; 70'). The limiter (100; 100'; 100"; 100') and one of the parts (110; 10') axially coupled to the housing (10; 10'; 10') includes a track, the track and the limiter (100; 100'; 100"; 100') engage with a blocking feature (112; 112'; 112') of another of the parts axially coupled to the housing (10; 10'; 10'). The track includes at least one narrow portion that restricts relative axial movement between the track and the blocking feature (112; 112'; 112') and at least one wide portion that allows the track and the blocking feature (112; 112'; 112 ') relative axial movement between.

The present invention relates to a system for predicting the low response probability of the ovary of a subject under an antagonist regimen and a system for guiding the selection of the starting dose of gonadotropin. The system for predicting the probability of low ovarian response includes: a data acquisition module for acquiring the subject's age, anti-Mullerian hormone (AMH) level, follicle stimulating hormone (FSH) level, antral follicle count ( AFC) data; and a module for calculating the probability of low ovarian response, which is used to calculate the information obtained in the data acquisition module to calculate the probability of low ovarian response in the subject, and calculate the probability of low response according to the predicted low response probability. Give exogenous gonadotropin (Gn) starting dose recommendations.

The present invention generally relates to a drug delivery device for selecting and dispensing a plurality of user variable doses of medicaments. The device comprises: a housing (10); a dose selector (80) operable to set the dose by rotation relative to the housing (10); a number sleeve (60) disposed on the housing (10) inside, so that at least a part of the number sleeve (60) is visible through the first aperture (11b) in the housing (10); the piston rod (30), which is coupled to said housing (10) and the drive sleeve ( 40), such that rotation of the drive sleeve (40) relative to the housing (10) causes translation of the piston rod (30) relative to the housing (10); and a clutch mechanism disposed between the number sleeve (60) and the drive sleeve between the cylinders (40). The clutch mechanism includes: a first coupling portion (42, 62), which is used to constrain the drive sleeve (40) and the number sleeve (60) together in rotation according to the axial position of the drive sleeve (60) ; the second coupling portion (43, 121), which is used to connect the drive sleeve (40) and the number sleeve according to the axial position of the drive sleeve (40) and / or according to the bias of the clutch spring (130). (60) are rotationally constrained together via clutch element (120).

The invention discloses an afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method comprises calculating all positions of stationary points on a source applicator and activating stationary points within a tumor target region; calculating the number of dose selection reference points in each image; and working out the optimal stationary point position and residence time through an internal-external double circulation mode. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation system comprises an image generation unit, a stationary point activation unit, a statistics unit and a circulation calculation unit. According to the invention, a customized anatomical structure is taken as the basis, the optimal combination mode of the radioactive source residence position and residence time is obtained by means of an internal-external double circulation searching mode, the customized afterloading radiotherapy dose inverse intensity-modulated optimizing demand can be satisfied, in the external circulation, a primary combination is solved by means of a relaxation method, in the internal circulation, by combining the expected dose of the tumor target region and the constraint dose which is dangerous to organs, the gradient of the stationary point position and the residence time is further optimized. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system can be widely applied to afterloading radiotherapy dose calculation.

An injection device incorporating a dose setting mechanism is presented where the dose setting mechanism contains a fail safe feature that activates during an interrupted dose delivery event. A dose selector having a projecting rib engages a protrusion on a snap element to prevent the dose knob from moving distally if a user removes an axial force in the proximal direction during dose delivery. The dose setting mechanism can further include a reuse prevention feature.