17 results about "Dose selection" patented technology

The invention relates to a multiuse fixed dose injection device for ejecting multiple pre-defined fixed doses of a liquid drug. The injection device comprises a housing structure, a dose selection button and a piston rod assembly. The housing structure is configured for holding a loaded cartridge containing the liquid drug. The dose selection button is functionally coupled to the housing structure for selecting one of the pre-defined fixed dose and the piston rod assembly is distally adapted to move a piston inside the loaded cartridge and adapted to carry a gear wheel, which is rotatably coupled with a piston rod. The injection device further comprises a first toothed rack associated with the housing structure and a second toothed rack associated with the dose button. The gear wheel and the first toothed rack are permanently engaged both during dose selection and during dose ejection, and the gear wheel and the second toothed rack are disengaged during dose selection and engaged during dose ejection.

A dial grip (10) for an injection device (50) includes a grip base (12), an operating portion (14) disposed on one side (16) of the grip base (12), and a coupling (18) disposed on the other side (20) of the grip base (12) for releasable engagement with a dose selecting portion of a dose selecting and expelling mechanism of the injection device to couple the grip base (12) to the dose selecting and expelling mechanism for selecting and expelling a dose with the dial grip (10).

In a dose setting mode of a dose delivery device, a dose selector is rotated to turn a nut, which thereby moves backward along a thread of a piston rod through a first axial distance. A gearing mechanism transmits the axial movement of the nut to a connector that moves backward, without rotation, through a second axial distance. In a dose delivery mode of the device, the dose selector is pushed forward and drives the connector to move forward through the second axial distance. The gearing mechanism transmits the axial movement of the connector to the nut, which pushes the piston rod forward, without rotation, through the first axial distance. The gearing mechanism includes a first gear that rotates without axial movement relative to the housing, and a second gear that rotates without axial movement relative to the nut.

The invention provides a micro-enema preparation and quantitative evaluation method for improving the quality of a rectum magnetic resonance image, and the method comprises the steps: S2, carrying out a glycerine enema micro-enema operation, squeezing glycerine enema into the rectum, maintaining the operation for a preset time, and recording the defecation frequency and the last defecation character; s3, selecting the dosage of the microenema enema, carrying out grouped experiments by setting a plurality of doses, recording related scores, and selecting the dosage of the enema enema meeting clinical requirements; s4, selecting an on-machine time window before magnetic resonance examination after microenema, performing rectum magnetic resonance examination at a plurality of time nodes after defecation through grouping experiments, observing related scores, and selecting an on-machine time window with a good intestinal tract preparation effect; and S5, carrying out micro-enema adverse reaction evaluation, evaluating a plurality of grades of the subject, calculating an adverse reaction score according to a weighting formula, carrying out clinical decision making, and if the adverse reaction score is lower than a threshold value, terminating the operation and carrying out further processing.

A system for containing and dispensing a cosmetic substance may include a container with a first end and a second end and a cavity for receiving the cosmetic substance, with a dispensing assembly coupled with the first end of the container, an urging assembly at least partially disposed within the container cavity, and a dose selection assembly that is movably coupled with the second end of the container and the urging assembly. Moving a portion of the dose selection assembly relative to the container causes the urging assembly to advance, which urges a desired quantity of the cosmetic substance from the container cavity to the dispensing assembly. A user may actuate the dispensing assembly to dispense the desired quantity of cosmetic substance.

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.

An embodiment of the present invention discloses a method for constructing a sepsis clinical decision-making model assisted by reinforcement learning, including: using multiple physiological indicators of sepsis patients in historical clinical data as state variables, and using the dose combination of intravenous infusion and vasopressor actually taken by doctors as action variables to construct training samples for the reinforcement learning model; building an agent model based on reinforcement learning according to the training samples, and the model includes a feature extraction layer, an embedding processing layer and a Q-value calculation layer; using the training samples to train the model in a reinforcement learning manner, and the trained model is used to recommend the best dose combination according to multiple physiological indicators of a patient at a certain moment; during the training process, the role of fluid balance and blood pressure in dose selection is enhanced through a reward function, and the role of blood protein and lactic acid is inhibited. This embodiment uses agent learning to assist sepsis clinical decision-making.

A medication delivery device is disclosed including a rack-and-pinion plunger drive system. The drive system includes an output drive having a pawled end movably coupled with the ratchet teeth of the plunger, and a pinion drive coupled between the housing, the output drive and an actuator. Actuator is longitudinally movable between dose set and delivery positions. Movement of the actuator causes rotation of the pinion drive along the rack to translate the output drive member with the pawled end that is engaged with the plunger ratchet teeth to distally advance the plunger. The device may include one or more of an end of dose mechanism to limit travel of the actuator, a load brake system to stop travel of the plunger under high input forces, a dose detection system, and a dose selector to vary the amount of dose set.

Injection monitoring module removably mountable to a proximal extremity of an injection pen comprising a pen body, a proximally located dose setting wheel, and an injection activator, the dose setting wheel rotating about a central longitudinal axis of the pen during dose setting, the injection monitoring module comprising a hollow main body coaxially mounted on, and engaging in co-rotation with the dose setting wheel, the main body comprising a longitudinal bore having a proximal and distal extremities, and a central longitudinal axis; one or more magnets located on or within the main body; an injection monitoring system comprising at least one magnetic sensor movable in translation along the central axis within the bore, from a first monitoring position, to a second monitoring position; the injection monitoring module further comprising a rotational stop means preventing rotational movement of the monitoring system about the central axis during dose selection.

An injection monitoring module comprises a main body, central bore, and central axis, and magnetic field production means located on the main body. An injection monitoring system comprising at least one magnetic sensor is translatable along the central axis and located within the bore. The monitoring module comprises a rotational stop means preventing rotational movement of the monitoring system about the central axis during dose selection. The stop means comprises a rotationally fixed coupling in parallel to the central axis, connecting the monitoring system to a body of an injection pen, and permitting translational movement of the monitoring system from a first monitoring position to a second monitoring position, during injection, and vice-versa, after injection. The stop means comprises relative positioning means selectively preventing, or allowing, translation of the monitoring system proximally from a first, collapsed position, to a second, deployed position.

An injection monitoring module is removably mounted on the proximal end of an injection pen comprising a pen body, a dose setting wheel located on the proximal end, and an injection initiator. The dose setting wheel rotates about the central longitudinal axis of the pen during dose setting. The injection monitoring module comprises a hollow body coaxially mounted on and co-rotatingly engaged with the dose setting wheel. The body comprises a longitudinal bore having a proximal end, a distal end, and a central longitudinal axis; one or more magnets located on or within the body. The injection monitoring system comprises at least one magnetic field sensor that moves along the central axis within the bore from a first monitoring position to a second monitoring position. The injection monitoring module further comprises a rotational stop for preventing rotational movement of the monitoring system about the central axis during dose selection.

Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.

A dispensing device (100) for dispensing a dose of a medicament is provided. The device comprises a feed channel (116) configured to receive a plurality of dosage units (104) of a medicament, a dose selection mechanism (108) configured to receive an input specifying a number of dosage units of the medicament to be dispensed from the feed channel, a dose separation mechanism (124) configured to separate a subset of the dosage units from the plurality of dosage units in the feed channel, and a dose dispensing mechanism (112) configured to dispense the separated subset of the dosage units from the feed channel. The dose selection mechanism is mechanically coupled to the dose separation mechanism to enable the dose separation mechanism to separate the specified number of dosage units from the plurality of dosage units in the feed channel.

The invention relates to the technical field of medicine information, and discloses a system and a method for accurately selecting tacrolimus treatment dosage of a myasthenia gravis patient. The method comprises the following steps: acquiring multi-cycle administration records and corresponding blood concentration of a patient to form an initial sequence; establishing a theoretical contribution degree matrix through lagging compensation, and reversely decomposing a pure single administration concentration curve; matching the curve with an individual pharmacokinetic template, and identifying an abnormal metabolic segment; and associating the same-period clinical records to generate clinical metabolism association pairs, establishing a mapping relation between concentration fluctuation and clinical symptoms, and classifying abnormal drug effect modes. According to the method, the independent metabolism trajectory of single administration can be analyzed from the mixed monitoring data, and the drug metabolism dynamics and the clinical effect are accurately associated, so that a technical basis is provided for realizing prospective individualized accurate administration.

To provide a syringe assembly that has efficient and improved accuracy of a medicament transferred.SOLUTION: A syringe assembly (2) that provides haptic feedback during dose setting comprises a syringe (10) and a dose selector. The syringe includes: a barrel (12) configured to carry a medicament; and a plunger (14) having a plunger head (16) disposed on a proximal end of the plunger, the plunger communicating with the barrel, the plunger including a plurality of axial ribs (24) extending along a length of the plunger and a notch 26 disposed in each axial rib. The dose selector (70) is disposed around the barrel, and passes through one of the notches to set a dose.SELECTED DRAWING: Figure 6

A system for containing and dispensing a cosmetic substance may include a container with a first end and a second end and a cavity for receiving the cosmetic substance, with a dispensing assembly coupled with the first end of the container, an urging assembly at least partially disposed within the container cavity, and a dose selection assembly that is movably coupled with the second end of the container and the urging assembly. Moving a portion of the dose selection assembly relative to the container causes the urging assembly to advance, which urges a desired quantity of the cosmetic substance from the container cavity to the dispensing assembly. A user may actuate the dispensing assembly to dispense the desired quantity of cosmetic substance.

In the dose setting mode of the dose delivery device, the dose selector (74) rotates to turn the nut (16) so that the nut moves backward along the thread (8) of the piston rod (6) by a first axial distance (d<subgt;1< / subgt>). The gearing mechanism transfers the axial movement of the nut (16) to the connector (20), which moves backward by a second axial distance (d<subgt;2< / subgt>) without rotating. In the dose delivery mode of the device, the dose selector (74) is pushed forward and drives the connector (20) to move forward by the second axial distance (d<subgt;2< / subgt>). The gearing mechanism transfers the axial movement of the connector (20) to the nut (16), which pushes the piston rod (6) forward by the first axial distance (d<subgt;1< / subgt>) without rotating. The gearing mechanism includes a first gear (28) that rotates relative to the housing (4) without axial movement and a second gear (30) that rotates relative to the nut (16) without axial movement.