8 results about "Dose selection" patented technology

A dial grip (10) for an injection device (50) includes a grip base (12), an operating portion (14) disposed on one side (16) of the grip base (12), and a coupling (18) disposed on the other side (20) of the grip base (12) for releasable engagement with a dose selecting portion of a dose selecting and expelling mechanism of the injection device to couple the grip base (12) to the dose selecting and expelling mechanism for selecting and expelling a dose with the dial grip (10).

In a dose setting mode of a dose delivery device, a dose selector is rotated to turn a nut, which thereby moves backward along a thread of a piston rod through a first axial distance. A gearing mechanism transmits the axial movement of the nut to a connector that moves backward, without rotation, through a second axial distance. In a dose delivery mode of the device, the dose selector is pushed forward and drives the connector to move forward through the second axial distance. The gearing mechanism transmits the axial movement of the connector to the nut, which pushes the piston rod forward, without rotation, through the first axial distance. The gearing mechanism includes a first gear that rotates without axial movement relative to the housing, and a second gear that rotates without axial movement relative to the nut.

The invention provides a micro-enema preparation and quantitative evaluation method for improving the quality of a rectum magnetic resonance image, and the method comprises the steps: S2, carrying out a glycerine enema micro-enema operation, squeezing glycerine enema into the rectum, maintaining the operation for a preset time, and recording the defecation frequency and the last defecation character; s3, selecting the dosage of the microenema enema, carrying out grouped experiments by setting a plurality of doses, recording related scores, and selecting the dosage of the enema enema meeting clinical requirements; s4, selecting an on-machine time window before magnetic resonance examination after microenema, performing rectum magnetic resonance examination at a plurality of time nodes after defecation through grouping experiments, observing related scores, and selecting an on-machine time window with a good intestinal tract preparation effect; and S5, carrying out micro-enema adverse reaction evaluation, evaluating a plurality of grades of the subject, calculating an adverse reaction score according to a weighting formula, carrying out clinical decision making, and if the adverse reaction score is lower than a threshold value, terminating the operation and carrying out further processing.

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.

Injection monitoring module removably mountable to a proximal extremity of an injection pen comprising a pen body, a proximally located dose setting wheel, and an injection activator, the dose setting wheel rotating about a central longitudinal axis of the pen during dose setting, the injection monitoring module comprising a hollow main body coaxially mounted on, and engaging in co-rotation with the dose setting wheel, the main body comprising a longitudinal bore having a proximal and distal extremities, and a central longitudinal axis; one or more magnets located on or within the main body; an injection monitoring system comprising at least one magnetic sensor movable in translation along the central axis within the bore, from a first monitoring position, to a second monitoring position; the injection monitoring module further comprising a rotational stop means preventing rotational movement of the monitoring system about the central axis during dose selection.

An injection monitoring module is removably mounted on the proximal end of an injection pen comprising a pen body, a dose setting wheel located on the proximal end, and an injection initiator. The dose setting wheel rotates about the central longitudinal axis of the pen during dose setting. The injection monitoring module comprises a hollow body coaxially mounted on and co-rotatingly engaged with the dose setting wheel. The body comprises a longitudinal bore having a proximal end, a distal end, and a central longitudinal axis; one or more magnets located on or within the body. The injection monitoring system comprises at least one magnetic field sensor that moves along the central axis within the bore from a first monitoring position to a second monitoring position. The injection monitoring module further comprises a rotational stop for preventing rotational movement of the monitoring system about the central axis during dose selection.

A dispensing device (100) for dispensing a dose of a medicament is provided. The device comprises a feed channel (116) configured to receive a plurality of dosage units (104) of a medicament, a dose selection mechanism (108) configured to receive an input specifying a number of dosage units of the medicament to be dispensed from the feed channel, a dose separation mechanism (124) configured to separate a subset of the dosage units from the plurality of dosage units in the feed channel, and a dose dispensing mechanism (112) configured to dispense the separated subset of the dosage units from the feed channel. The dose selection mechanism is mechanically coupled to the dose separation mechanism to enable the dose separation mechanism to separate the specified number of dosage units from the plurality of dosage units in the feed channel.

The invention relates to the technical field of medicine information, and discloses a system and a method for accurately selecting tacrolimus treatment dosage of a myasthenia gravis patient. The method comprises the following steps: acquiring multi-cycle administration records and corresponding blood concentration of a patient to form an initial sequence; establishing a theoretical contribution degree matrix through lagging compensation, and reversely decomposing a pure single administration concentration curve; matching the curve with an individual pharmacokinetic template, and identifying an abnormal metabolic segment; and associating the same-period clinical records to generate clinical metabolism association pairs, establishing a mapping relation between concentration fluctuation and clinical symptoms, and classifying abnormal drug effect modes. According to the method, the independent metabolism trajectory of single administration can be analyzed from the mixed monitoring data, and the drug metabolism dynamics and the clinical effect are accurately associated, so that a technical basis is provided for realizing prospective individualized accurate administration.