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Methods and devices for co-delivery of liquid and powdered hemostats and sealants

A technology for delivering devices and powders, which is used in the direction of nebulizers, infusion sets, and medicines for treatment.

Active Publication Date: 2018-01-26
IXIKANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These situations often require specialized equipment and materials and trained personnel to administer appropriate assistance

Method used

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  • Methods and devices for co-delivery of liquid and powdered hemostats and sealants
  • Methods and devices for co-delivery of liquid and powdered hemostats and sealants
  • Methods and devices for co-delivery of liquid and powdered hemostats and sealants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Peel tests were performed to compare various scenarios of codepositing powder-based and liquid-based materials for tissue sealing and hemostasis.

[0091] Porcine liver substrates were used for in vitro testing. Porcine plasma (Lampire Biological Laboratories, porcine plasma in sodium citrate) was sprayed (1 mL) onto transverse incisions (5 cm long and 2 cm wide at 1 cm intervals) of liver tissue and then placed consisting of a flat oval coil The test sample piece, the thickness of the line is 0.8mm; the width of the ellipse is 0.5cm and the length of the ellipse is 3cm, the test sample piece is placed flat on the tissue and extends perpendicularly from the sample piece perpendicular to the tissue surface hook connection. ORC powder was used as the powder component [lot number RC032614-A, the particle size distribution analyzed by the QUIPIC particle imaging system was 94um (d10), 183um (d50), 320um (d90), and the Hausner ratio (based on USP 616) was 1.32]. The powder...

Embodiment 2

[0106] Tests were performed on pig liver substrates in the absence of plasma. The different components shown in Table 2 were deposited on the substrate in the absence of plasma. The resulting coating was then manually stripped using duck-head tweezers, and the ease of manual stripping was estimated on a scale of 0-5. Composition includes

[0107] Fluid-Free ORC Powder

[0108] Fluid without ORC powder (Evicel)

[0109] Fluid (Evicel) then ORC powder in 120 seconds

[0110] ORC powder then fluid in 10 seconds (Evicel)

[0111] Fluid (Evicel) then ORC powder in 5 seconds

[0112] ORC powder and fluid (Evicel) were co-sprayed and then mixed on the tissue surface.

[0113] Co-spray ORC powder and fluid (Evicel) then ORC powder

[0114] Table 2: Estimated ease of stripping in the absence of plasma, test parameters and results

[0115]

[0116] The test results presented in Table 2 indicate that ORC powder then fluid (Evicel) and fluid (Evicel) then ORC powder showed en...

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Abstract

The invention relates to methods and devices for co-delivery of liquid and powdered hemostats and sealants. The present invention is directed to an integrated delivery device that is operable with onehand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using suchintegrated devices.

Description

Background technique [0001] Animals, including humans, can suffer from bleeding from wounds or during surgical procedures in a wide variety of situations. In some cases, the bleeding is relatively minor, and normal coagulation is all that is required other than the application of simple first aid. In other cases, heavy bleeding can occur. These situations often require specialized equipment and materials and trained personnel to administer appropriate assistance. [0002] In an effort to address the above-mentioned problems, materials for controlling excessive bleeding have been developed. Topically absorbable hemostats (TAHs) are widely used in surgical applications. TAH covers products based on oxidized cellulose (OC), oxidized regenerated cellulose (ORC), gelatin, collagen, chitin, chitosan, starch, etc. To improve hemostatic properties, scaffolds based on the above-mentioned materials can be combined with coagulation factors of biological origin, such as thrombin and f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/48A61M5/315A61M5/31A61B17/00A61M11/00A61M15/00
CPCA61B17/00491A61B2017/00495A61B2017/00522A61M11/007A61M15/0003A61M5/3137A61M5/31596A61M5/48A61M2005/31598A61M2202/064
Inventor 王奕嵐L.B.克里克苏诺夫
Owner IXIKANG CO LTD
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