Ultrasound micro-needle composite transdermal drug delivery device

Abstract

The invention relates to an ultrasound micro-needle composite transdermal drug delivery device which comprises an ultrasound transdermal drug delivery system and a porous micro-needle transdermal drug delivery system. The ultrasound transdermal drug delivery system comprises an ultrasonator, a control mechanism and an ultrasonic wave transmission dielectric layer arranged on the outer side of an end plate of a shell; the porous micro-needle transdermal drug delivery system comprises a drug storage pool, a liquid inlet pipe, a miniature peristaltic pump, a liquid outlet pipe, a drug inlet pool and poly-p-xylylene thin film, a plurality of micro needles are arranged on the poly-p-xylylene thin film, one end of each micro needle is communicated with the drug inlet pool, and the other end of each micro needle is used for being in contact with the skin for drug delivery. The ultrasound micro-needle composite transdermal drug delivery device solves the technical problems that irritabilities of patients are prone to being caused by an existing transdermal drug delivery device, the existing transdermal drug delivery device is low in drug delivery speed and poor in drug delivery effect, and the lengths of the micro needles cannot be adjusted when the existing transdermal drug delivery device acts on different parts of the human body so that the existing transdermal drug delivery device is limited in application range; the ultrasound micro-needle composite transdermal drug delivery device is high in drug delivery speed, good in drug delivery effect and suitable for application and popularization.

Description

technical field [0001] The invention relates to a transdermal drug delivery device which uses ultrasonic vibration and a porous microneedle structure to allow medicine to permeate part of the organism. Background technique [0002] Transdermal Drug Delivery (TDD) refers to the absorption of drugs through the skin into the blood circulation at a certain rate to achieve effective blood drug concentration and achieve the treatment or prevention of diseases. With the development of biotechnology, there are more and more biological agents based on macromolecules such as polypeptides, proteins, and oligonucleotides. The route of administration is a common problem encountered in the clinical application of biological agents. Because biological agents are easily degraded in the liver and gastrointestinal tract when taken orally, reducing the effective availability of biological agents; it is difficult to maintain a stable blood concentration in the body when injected, and frequent i...

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the technical problems of the existing transdermal drug delivery device, individual patients are prone to skin allergies, the drug delivery speed is slow, the drug delivery effect is poor, and the length of the microneedle is not adjustable when the device acts on different parts of the human body, resulting in limited application range. The present invention provides a A new type of transdermal drug delivery device that can speed up the skin's drug absorption rate, reduce skin allergies, and has wide applicability

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